(data stored in ACNUC1104 zone)

SWISSPROT: MSHB_STRCO

ID   MSHB_STRCO              Reviewed;         295 AA.
AC   Q9F344;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   08-MAY-2019, entry version 76.
DE   RecName: Full=1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase {ECO:0000255|HAMAP-Rule:MF_01696};
DE            Short=GlcNAc-Ins deacetylase {ECO:0000255|HAMAP-Rule:MF_01696};
DE            EC=3.5.1.103 {ECO:0000255|HAMAP-Rule:MF_01696};
DE   AltName: Full=N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase;
GN   Name=mshB {ECO:0000255|HAMAP-Rule:MF_01696};
GN   OrderedLocusNames=SCO5126; ORFNames=SC9E12.11;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   INDUCTION.
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=18430082; DOI=10.1111/j.1365-2958.2008.06191.x;
RA   Park J.H., Roe J.H.;
RT   "Mycothiol regulates and is regulated by a thiol-specific antisigma
RT   factor RsrA and sigma(R) in Streptomyces coelicolor.";
RL   Mol. Microbiol. 68:861-870(2008).
CC   -!- FUNCTION: Catalyzes the deacetylation of 1D-myo-inositol 2-
CC       acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the
CC       mycothiol biosynthesis pathway. {ECO:0000255|HAMAP-Rule:MF_01696}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-
CC         glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-
CC         glucopyranoside + acetate; Xref=Rhea:RHEA:26180,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:52442,
CC         ChEBI:CHEBI:58886; EC=3.5.1.103; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01696};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01696};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_01696};
CC   -!- INDUCTION: Gradually induced by thiol-oxidant diamide, under
CC       (probably indirect) control of SigR.
CC       {ECO:0000269|PubMed:18430082}.
CC   -!- SIMILARITY: Belongs to the MshB deacetylase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01696}.
DR   EMBL; AL939122; CAC05756.1; -; Genomic_DNA.
DR   RefSeq; NP_629275.1; NC_003888.3.
DR   RefSeq; WP_011030070.1; NC_003888.3.
DR   SMR; Q9F344; -.
DR   STRING; 100226.SCO5126; -.
DR   EnsemblBacteria; CAC05756; CAC05756; CAC05756.
DR   GeneID; 1100567; -.
DR   KEGG; sco:SCO5126; -.
DR   PATRIC; fig|100226.15.peg.5209; -.
DR   eggNOG; COG2120; LUCA.
DR   HOGENOM; HOG000241173; -.
DR   InParanoid; Q9F344; -.
DR   KO; K15525; -.
DR   OMA; KFYWTVT; -.
DR   PhylomeDB; Q9F344; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0035595; F:N-acetylglucosaminylinositol deacetylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0010125; P:mycothiol biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10320; -; 1.
DR   HAMAP; MF_01696; MshB; 1.
DR   InterPro; IPR003737; GlcNAc_PI_deacetylase-related.
DR   InterPro; IPR024078; LmbE-like_dom_sf.
DR   InterPro; IPR017810; Mycothiol_biosynthesis_MshB.
DR   PANTHER; PTHR12993; PTHR12993; 1.
DR   Pfam; PF02585; PIG-L; 1.
DR   SUPFAM; SSF102588; SSF102588; 1.
DR   TIGRFAMs; TIGR03445; mycothiol_MshB; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9F344.
DR   SWISS-2DPAGE; Q9F344.
KW   Complete proteome; Hydrolase; Metal-binding; Reference proteome; Zinc.
FT   CHAIN         1    295       1D-myo-inositol 2-acetamido-2-deoxy-
FT                                alpha-D-glucopyranoside deacetylase.
FT                                /FTId=PRO_0000400226.
FT   METAL        15     15       Zinc. {ECO:0000255|HAMAP-Rule:MF_01696}.
FT   METAL        18     18       Zinc. {ECO:0000255|HAMAP-Rule:MF_01696}.
FT   METAL       147    147       Zinc. {ECO:0000255|HAMAP-Rule:MF_01696}.
SQ   SEQUENCE   295 AA;  31433 MW;  0EBA7027EF891ED8 CRC64;
     MTDLPGRRLL LVHAHPDDES INNGVTMARY AAEGAHVTLV TCTLGERGEV IPPALAHLSG
     AALGGHRRGE LADAMRALGV DDFRLLGGPG RYADSGMLGL SDNDDPGCLW QADVDAAAAL
     LVDVIREVRP QVLVTYDPNG GYGHPDHIQA HRIAMRAAEL AAEAGCPVAK VYWNRVPRSR
     VEDAFARLRD DLPGLPFEKA AGVEDVPGVV DDERITTEIR GEGTAYAAAK AAAMRAHATQ
     ITVAEPYFVL SNDLAQPILT TEYYELVRGE RGGEGRENDL FAGIAGTFDT GEATS
//

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