(data stored in ACNUC1104 zone)

SWISSPROT: KASB_STRCO

ID   KASB_STRCO              Reviewed;         407 AA.
AC   Q02062;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   08-MAY-2019, entry version 101.
DE   RecName: Full=Actinorhodin polyketide putative beta-ketoacyl synthase 2;
DE            EC=2.3.1.-;
DE   AltName: Full=actI ORF2;
GN   OrderedLocusNames=SCO5088; ORFNames=SCBAC28G1.14;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=1527048;
RA   Fernandez-Moreno M.A., Martinez E., Boto L., Hopwood D.A.,
RA   Malpartida F.;
RT   "Nucleotide sequence and deduced functions of a set of cotranscribed
RT   genes of Streptomyces coelicolor A3(2) including the polyketide
RT   synthase for the antibiotic actinorhodin.";
RL   J. Biol. Chem. 267:19278-19290(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- MISCELLANEOUS: This putative ketoacyl synthase lacks the active
CC       site cysteine.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-
CC       ketoacyl-ACP synthases family. {ECO:0000305}.
DR   EMBL; X63449; CAA45044.1; -; Genomic_DNA.
DR   EMBL; AL939122; CAC44201.1; -; Genomic_DNA.
DR   PIR; S25841; S25841.
DR   RefSeq; NP_629238.1; NC_003888.3.
DR   RefSeq; WP_011030048.1; NC_003888.3.
DR   PDB; 1QXG; Model; -; B=1-404.
DR   PDB; 1TQY; X-ray; 2.00 A; B/D/F/H=2-407.
DR   PDBsum; 1QXG; -.
DR   PDBsum; 1TQY; -.
DR   SMR; Q02062; -.
DR   IntAct; Q02062; 1.
DR   STRING; 100226.SCO5088; -.
DR   PRIDE; Q02062; -.
DR   EnsemblBacteria; CAC44201; CAC44201; CAC44201.
DR   GeneID; 1100529; -.
DR   KEGG; sco:SCO5088; -.
DR   PATRIC; fig|100226.15.peg.5168; -.
DR   eggNOG; ENOG4105CZS; Bacteria.
DR   eggNOG; COG0304; LUCA.
DR   HOGENOM; HOG000060166; -.
DR   InParanoid; Q02062; -.
DR   KO; K05552; -.
DR   OMA; AWFYAVN; -.
DR   PhylomeDB; Q02062; -.
DR   EvolutionaryTrace; Q02062; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IBA:GO_Central.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
PE   1: Evidence at protein level;
DR   PRODOM; Q02062.
DR   SWISS-2DPAGE; Q02062.
KW   3D-structure; Acyltransferase; Antibiotic biosynthesis;
KW   Complete proteome; Reference proteome; Transferase.
FT   CHAIN         1    407       Actinorhodin polyketide putative beta-
FT                                ketoacyl synthase 2.
FT                                /FTId=PRO_0000180349.
FT   STRAND        3     12       {ECO:0000244|PDB:1TQY}.
FT   STRAND       15     17       {ECO:0000244|PDB:1TQY}.
FT   HELIX        18     26       {ECO:0000244|PDB:1TQY}.
FT   STRAND       32     34       {ECO:0000244|PDB:1TQY}.
FT   TURN         36     39       {ECO:0000244|PDB:1TQY}.
FT   HELIX        40     42       {ECO:0000244|PDB:1TQY}.
FT   STRAND       47     49       {ECO:0000244|PDB:1TQY}.
FT   HELIX        56     59       {ECO:0000244|PDB:1TQY}.
FT   TURN         62     64       {ECO:0000244|PDB:1TQY}.
FT   HELIX        65     67       {ECO:0000244|PDB:1TQY}.
FT   HELIX        70     85       {ECO:0000244|PDB:1TQY}.
FT   HELIX        90     92       {ECO:0000244|PDB:1TQY}.
FT   HELIX        95     97       {ECO:0000244|PDB:1TQY}.
FT   STRAND       98    103       {ECO:0000244|PDB:1TQY}.
FT   HELIX       109    121       {ECO:0000244|PDB:1TQY}.
FT   HELIX       124    126       {ECO:0000244|PDB:1TQY}.
FT   HELIX       131    134       {ECO:0000244|PDB:1TQY}.
FT   HELIX       139    148       {ECO:0000244|PDB:1TQY}.
FT   STRAND      155    158       {ECO:0000244|PDB:1TQY}.
FT   HELIX       160    162       {ECO:0000244|PDB:1TQY}.
FT   HELIX       163    176       {ECO:0000244|PDB:1TQY}.
FT   STRAND      180    188       {ECO:0000244|PDB:1TQY}.
FT   HELIX       193    200       {ECO:0000244|PDB:1TQY}.
FT   HELIX       211    213       {ECO:0000244|PDB:1TQY}.
FT   STRAND      230    238       {ECO:0000244|PDB:1TQY}.
FT   HELIX       239    245       {ECO:0000244|PDB:1TQY}.
FT   STRAND      251    261       {ECO:0000244|PDB:1TQY}.
FT   HELIX       273    284       {ECO:0000244|PDB:1TQY}.
FT   HELIX       288    290       {ECO:0000244|PDB:1TQY}.
FT   STRAND      293    295       {ECO:0000244|PDB:1TQY}.
FT   HELIX       302    316       {ECO:0000244|PDB:1TQY}.
FT   STRAND      321    324       {ECO:0000244|PDB:1TQY}.
FT   HELIX       326    329       {ECO:0000244|PDB:1TQY}.
FT   HELIX       334    336       {ECO:0000244|PDB:1TQY}.
FT   HELIX       337    351       {ECO:0000244|PDB:1TQY}.
FT   HELIX       365    367       {ECO:0000244|PDB:1TQY}.
FT   STRAND      373    375       {ECO:0000244|PDB:1TQY}.
FT   STRAND      382    390       {ECO:0000244|PDB:1TQY}.
FT   TURN        391    393       {ECO:0000244|PDB:1TQY}.
FT   STRAND      394    402       {ECO:0000244|PDB:1TQY}.
SQ   SEQUENCE   407 AA;  42550 MW;  59FC75A5A0D94632 CRC64;
     MSVLITGVGV VAPNGLGLAP YWSAVLDGRH GLGPVTRFDV SRYPATLAGQ IDDFHAPDHI
     PGRLLPQTDP STRLALTAAD WALQDAKADP ESLTDYDMGV VTANACGGFD FTHREFRKLW
     SEGPKSVSVY ESFAWFYAVN TGQISIRHGM RGPSSALVAE QAGGLDALGH ARRTIRRGTP
     LVVSGGVDSA LDPWGWVSQI ASGRISTATD PDRAYLPFDE RAAGYVPGEG GAILVLEDSA
     AAEARGRHDA YGELAGCAST FDPAPGSGRP AGLERAIRLA LNDAGTGPED VDVVFADGAG
     VPELDAAEAR AIGRVFGREG VPVTVPKTTT GRLYSGGGPL DVVTALMSLR EGVIAPTAGV
     TSVPREYGID LVLGEPRSTA PRTALVLARG RWGFNSAAVL RRFAPTP
//

If you have problems or comments...

PBIL Back to PBIL home page