(data stored in ACNUC9435 zone)

SWISSPROT: UVRC_LISIN

ID   UVRC_LISIN              Reviewed;         603 AA.
AC   Q92CH5;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   11-DEC-2019, entry version 99.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=lin1197;
OS   Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=272626;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-680 / CLIP 11262;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
DR   EMBL; AL596167; CAC96428.1; -; Genomic_DNA.
DR   PIR; AD1582; AD1582.
DR   RefSeq; WP_003771538.1; NC_003212.1.
DR   SMR; Q92CH5; -.
DR   STRING; 272626.lin1197; -.
DR   PRIDE; Q92CH5; -.
DR   EnsemblBacteria; CAC96428; CAC96428; CAC96428.
DR   KEGG; lin:uvrC; -.
DR   eggNOG; ENOG4105CII; Bacteria.
DR   eggNOG; COG0322; LUCA.
DR   HOGENOM; HOG000279960; -.
DR   KO; K03703; -.
DR   OMA; LFPIRQC; -.
DR   OrthoDB; 1036075at2; -.
DR   BioCyc; GCF_000195795:LIN_RS06105-MONOMER; -.
DR   Proteomes; UP000002513; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_homol_region.
DR   InterPro; IPR038476; UvrC_homol_region_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q92CH5.
DR   SWISS-2DPAGE; Q92CH5.
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..603
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138312"
FT   DOMAIN          15..92
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          197..232
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   603 AA;  69302 MW;  8FA17669DB8EAFA1 CRC64;
     MSSEHIQNKL ALLPDQPGCY LMKDRQGTII YVGKAKVLKN RVRSYFSGTH DSKTQRLVQE
     IVDFEYIVTS SNVEALLLEI NLIKKHDPRF NIRLKDDKTY PFIKITNERH PRLIITRQVK
     KDKGKYFGPY PNVYAANEVK RILDRLYPLR KCSTLPNKVC LYYHLGQCLA PCVFDVEASK
     YKEMQDEIVA FLNGGYKTVK NDLMKKMQEA AENMEFEKAG EFRDQINAIE TTMEKQKMTM
     NDFVDRDVFG YAIDKGWMCV QVFFIRQGKL IERDVSQFPF YNDADEDFLT FIGQFYQKAN
     HIPPKEIYLP DDVDSEAVQA VVPDTKIIVP QRGNKKELVK LAYKNAKIAL NEKFMLLERN
     EERTVGAVER LGEAMGIPTP SRVEAFDNSN IHGTDPVSAM VTFLDGKPSK NDYRKYKIKT
     VEGPDDYATM REVIRRRYWR VLKEGLPMPD LILIDGGKGQ IDSAKDVLTN ELGLDIPVAG
     LAKDDKHRTS QLLFGDPLEI VPLERNSQEF YLLQRMQDEV HRFAITFHRQ LRSKTGFQSI
     LDGIPGVGPG RKKKLLKHFG SMKKLKEASV EEIKEAGVPL NVAEEVHKHI TAFNEKAKNT
     EQK
//

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