(data stored in ACNUC1104 zone)

SWISSPROT: GREA_STRCO

ID   GREA_STRCO              Reviewed;         165 AA.
AC   Q9ADK2;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   08-MAY-2019, entry version 105.
DE   RecName: Full=Transcription elongation factor GreA {ECO:0000255|HAMAP-Rule:MF_00105};
DE   AltName: Full=Transcript cleavage factor GreA {ECO:0000255|HAMAP-Rule:MF_00105};
GN   Name=greA {ECO:0000255|HAMAP-Rule:MF_00105};
GN   OrderedLocusNames=SCO4965; ORFNames=2SCK31.25c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting
CC       sites in DNA have the property of trapping a certain fraction of
CC       elongating RNA polymerases that pass through, resulting in locked
CC       ternary complexes. Cleavage of the nascent transcript by cleavage
CC       factors such as GreA or GreB allows the resumption of elongation
CC       from the new 3'terminus. GreA releases sequences of 2 to 3
CC       nucleotides. {ECO:0000255|HAMAP-Rule:MF_00105}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00105}.
DR   EMBL; AL939122; CAD30950.1; -; Genomic_DNA.
DR   RefSeq; NP_629117.1; NC_003888.3.
DR   RefSeq; WP_003974011.1; NC_003888.3.
DR   SMR; Q9ADK2; -.
DR   STRING; 100226.SCO4965; -.
DR   EnsemblBacteria; CAD30950; CAD30950; CAD30950.
DR   GeneID; 1100406; -.
DR   KEGG; sco:SCO4965; -.
DR   PATRIC; fig|100226.15.peg.5045; -.
DR   eggNOG; ENOG4107YD5; Bacteria.
DR   eggNOG; COG0782; LUCA.
DR   HOGENOM; HOG000241146; -.
DR   InParanoid; Q9ADK2; -.
DR   KO; K03624; -.
DR   OMA; TWLTQEA; -.
DR   PhylomeDB; Q9ADK2; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0006354; P:DNA-templated transcription, elongation; IBA:GO_Central.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.180; -; 1.
DR   Gene3D; 3.10.50.30; -; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   InterPro; IPR036953; GreA/GreB_C_sf.
DR   InterPro; IPR018151; TF_GreA/GreB_CS.
DR   InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR   PANTHER; PTHR30437; PTHR30437; 1.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   PIRSF; PIRSF006092; GreA_GreB; 1.
DR   SUPFAM; SSF46557; SSF46557; 1.
DR   TIGRFAMs; TIGR01462; greA; 1.
DR   PROSITE; PS00829; GREAB_1; 1.
DR   PROSITE; PS00830; GREAB_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q9ADK2.
DR   SWISS-2DPAGE; Q9ADK2.
KW   Coiled coil; Complete proteome; DNA-binding; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN         1    165       Transcription elongation factor GreA.
FT                                /FTId=PRO_0000176978.
FT   COILED       55     78       {ECO:0000255|HAMAP-Rule:MF_00105}.
SQ   SEQUENCE   165 AA;  17843 MW;  D2575DE4AD32CB06 CRC64;
     MTQTSENVTW LTQEAYNKLK EELEYLTGPA RTEISAKIAA AREEGDLREN GGYHAAKEEQ
     GKQELRVRQL TQLLESAKVG EAPAADGVVA PGMVVTIAFD GDEDDTLTFL LASREYASSD
     IETYSPQSPL GSGVLGHKVG DDAQYELPNG KPASVRILKA EPYNG
//

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