(data stored in ACNUC1104 zone)

SWISSPROT: Q9EWH2_STRCO

ID   Q9EWH2_STRCO            Unreviewed;       235 AA.
AC   Q9EWH2;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   08-MAY-2019, entry version 120.
DE   SubName: Full=Putative tetR-family transcriptional regulator {ECO:0000313|EMBL:CAD30962.1};
GN   OrderedLocusNames=SCO4977 {ECO:0000313|EMBL:CAD30962.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226 {ECO:0000313|Proteomes:UP000001973};
RN   [1] {ECO:0000313|EMBL:CAD30962.1, ECO:0000313|Proteomes:UP000001973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145
RC   {ECO:0000313|Proteomes:UP000001973};
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.H., Kieser T., Larke L., Murphy L., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
RN   [2] {ECO:0000213|PDB:2OF7}
RP   X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 3-235.
RA   Tan K., Xu X., Zheng H., Savchenko A., Edwards A., Joachimiak A.;
RT   "The crystal structure of a tetR-family transcriptional regulator from
RT   Streptomyces coelicolor A3.";
RL   Submitted (JAN-2007) to the PDB data bank.
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DR   EMBL; AL939122; CAD30962.1; -; Genomic_DNA.
DR   RefSeq; NP_629129.1; NC_003888.3.
DR   RefSeq; WP_011029983.1; NC_003888.3.
DR   PDB; 2OF7; X-ray; 2.30 A; A=2-235.
DR   PDBsum; 2OF7; -.
DR   SMR; Q9EWH2; -.
DR   STRING; 100226.SCO4977; -.
DR   EnsemblBacteria; CAD30962; CAD30962; CAD30962.
DR   GeneID; 1100418; -.
DR   KEGG; sco:SCO4977; -.
DR   PATRIC; fig|100226.15.peg.5058; -.
DR   eggNOG; ENOG4105QZA; Bacteria.
DR   eggNOG; COG1309; LUCA.
DR   HOGENOM; HOG000043629; -.
DR   InParanoid; Q9EWH2; -.
DR   OMA; MYGIPEA; -.
DR   PhylomeDB; Q9EWH2; -.
DR   EvolutionaryTrace; Q9EWH2; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR041347; MftR_C.
DR   Pfam; PF17754; TetR_C_14; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q9EWH2.
DR   SWISS-2DPAGE; Q9EWH2.
KW   3D-structure {ECO:0000213|PDB:2OF7};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001973};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335,
KW   ECO:0000256|SAAS:SAAS00132209};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW   Transcription {ECO:0000256|SAAS:SAAS00131596};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00132066}.
FT   DOMAIN       24     84       HTH tetR-type. {ECO:0000259|PROSITE:
FT                                PS50977}.
FT   DNA_BIND     47     66       H-T-H motif. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00335}.
SQ   SEQUENCE   235 AA;  26104 MW;  1C5B16F243362999 CRC64;
     MTAARSAPSP AGAPRPGLRE RKKTRTREAI RAATYGLIRQ QGYEATTVEQ IAERAEVSPS
     TVLRYFPTRE DIVLTDEYDP VMAAELAARP AGEPWSDSLR HVLRKALGLG AGEEAELIRL
     RTRLLAEVPA VRARMLENMS DTGRMLARAI ADRTGLDPDG LEVRIVSMSL VGGLMEVSRY
     WAEHDHEESL AELVDRALDA LENGLPALRE SDRESDREGD RGGHREDRRE GPRKD
//

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