(data stored in ACNUC9543 zone)

SWISSPROT: Q8IBB3_PLAF7

ID   Q8IBB3_PLAF7            Unreviewed;      1481 AA.
AC   Q8IBB3;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 120.
DE   SubName: Full=Leucine--tRNA ligase, putative {ECO:0000313|EMBL:CAD51093.1};
DE            EC=6.1.1.4 {ECO:0000313|EMBL:CAD51093.1};
GN   ORFNames=PF3D7_0828200 {ECO:0000313|EMBL:CAD51093.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51093.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|RuleBase:RU363035}.
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DR   EMBL; AL844507; CAD51093.1; -; Genomic_DNA.
DR   RefSeq; XP_001349244.1; XM_001349208.1.
DR   SMR; Q8IBB3; -.
DR   PRIDE; Q8IBB3; -.
DR   EnsemblProtists; CAD51093; CAD51093; PF3D7_0828200.
DR   GeneDB; PF3D7_0828200.1:pep; -.
DR   GeneID; 2655460; -.
DR   KEGG; pfa:PF3D7_0828200; -.
DR   EuPathDB; PlasmoDB:PF3D7_0828200; -.
DR   HOGENOM; HOG000282581; -.
DR   InParanoid; Q8IBB3; -.
DR   KO; K01869; -.
DR   OMA; WDYIPLK; -.
DR   PhylomeDB; Q8IBB3; -.
DR   BioCyc; PLASMO:PF08_0011-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004823; F:leucine-tRNA ligase activity; ISS:GeneDB.
DR   GO; GO:0006429; P:leucyl-tRNA aminoacylation; ISS:GeneDB.
DR   GO; GO:0032543; P:mitochondrial translation; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; ISS:GeneDB.
DR   Gene3D; 3.40.50.620; -; 3.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR002302; Leu-tRNA-ligase.
DR   InterPro; IPR025709; Leu_tRNA-synth_edit.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR43740; PTHR43740; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF00133; tRNA-synt_1; 3.
DR   Pfam; PF13603; tRNA-synt_1_2; 1.
DR   PRINTS; PR00985; TRNASYNTHLEU.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8IBB3.
DR   SWISS-2DPAGE; Q8IBB3.
KW   Aminoacyl-tRNA synthetase {ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|RuleBase:RU363035, ECO:0000313|EMBL:CAD51093.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..1481
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004310009"
FT   TRANSMEM        370..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        625..650
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          121..276
FT                   /note="tRNA-synt_1"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          562..652
FT                   /note="tRNA-synt_1_2"
FT                   /evidence="ECO:0000259|Pfam:PF13603"
FT   DOMAIN          674..750
FT                   /note="tRNA-synt_1"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          1119..1156
FT                   /note="tRNA-synt_1"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          1317..1413
FT                   /note="Anticodon_1"
FT                   /evidence="ECO:0000259|Pfam:PF08264"
SQ   SEQUENCE   1481 AA;  178430 MW;  C5A30825CEF0191D CRC64;
     MFFKFVRFLI YIFLYSLCYQ HVNNVFALHI NKYKNVFLFE SPSVLIKNRR NYKRKIYSHD
     EEKGKYDFHR IEEKWQTIWN SKRLLDKDFE QYNKINLGRK EKKEKRHKDK QNGFIDKPYN
     DVYEKGDNTY KYNKKKFYIL DMFPYPSSEG LHVGHILCFT ITDIISKFKK MNNYCVFHPI
     GWDSFGLPCD RLSMKKKIDP REIIHKNISN FKNQLIKLGF LFNWESEINT CDENYYKWTQ
     WIIIQLFLNN LSYKKRSYVN WSNELRCVIS NDELRNEINL QYLNIQKIKL LQWYLKITKY
     ANRLIKDLNM IHWPMKIKNM QINWIGKKTG IFLKARIISL DKFLNNTHFN FVNIKKSYNN
     NMINVFYNNI FNHLFFIFIN YILSIFTFHM YINNPNEQKQ QQKKNTHIKE LNNKIQKYNY
     INKYDFFFSY HQNDLFLFFS FFFNYYHNRN IDQMKKQKLN LPTEPFKNEQ IRVSHNKENN
     NNSSNLETNW VSFNIQNCND MIINILFNNM ETYNENYFLY PLKDATKGKN YINGHNSNDN
     MFNDNMFNDN MFDDNMFDDN MLKDQNSYVQ IFLNKNEVIL QNDKLIISVN HPNIRNIVNH
     NPFLLKFIDK MVLENDTVRL KNEELYFTGS VIYFPIMNKM IPVFLCAYIL DNNKNFLFLK
     KEMTQTQDKN SNTNISLLYK MLQDSNYSKK KNIYNLKDWL FSRQRYWGEP FPFLYKMKDK
     NGYMDNTKIK NDDHMNENNH NNNMLSDCKD INNFSNYNDQ NNNKKIRIRK VINSPNNNIY
     IDDIPLKLPN FNKKIYEIDP HNEQDVNNIS SVLSRFKKWM ITKKYNMLYK RESDIMPQWA
     GSSWYFLRYI DSKNKKRIFN KKKINSWLPV DLYVGGSEHA VLHLLYSRFF HKFLYDLKLT
     KHKEPFQKLF NQGLLLNTTS FYLYTTLDNK PVSFDQINEK KINTNAYDYT NRGTNHHIQL
     NKKENEKKKK TYSQNVCETT NLLTSQVLPD HASFCSGDQN GNINKELKNE RNENMKEKDI
     DILRKSKIND DMKEKAIDML GKNRINDDMK EKAIDMLGKN KINDDMKENV IDMLGKNNYT
     IVDNKYKKFL IEEDYVKEGK DQKYYLKSFP SIEVQPNYEK MSKSKGNTIN PLDIVKTYGS
     DCLRLHILFL GPVDQNKKWT TKGIKGTFKF LNNLYNLFIQ RCDIKNNKES NKKNVCTRVV
     DNSMNDMMFH KDNIEKSANH ILSNNGYEKK KKINLENGEK KIEYMICKNC KRKSSNKKLI
     LNFLKNKYGF IIANEKYKKV NDYVNIILKN DSHVFNKLSD KIKKIKIEDI ENEKKKKVNY
     YIEKITNCIN DIKLNTAVSF FMKFYNEIKT WDIVPLKIFI IFVKLLYPFC PHICEEFWFY
     YLKRYKIKKR KKLCYFCNSN LLYYGKWPSL FEIKQNKLVN ISIKLNNKHI TFLQRDVSST
     SDITEEATNL IKHKIENEMK KGKKIVNIVN IPNKVINFII K
//

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