(data stored in ACNUC9543 zone)

SWISSPROT: Q8IBA3_PLAF7

ID   Q8IBA3_PLAF7            Unreviewed;      1397 AA.
AC   Q8IBA3;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 118.
DE   SubName: Full=Translation initiation factor IF-2, putative {ECO:0000313|EMBL:CAD51104.1};
GN   ORFNames=PF3D7_0827100 {ECO:0000313|EMBL:CAD51104.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51104.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51104.1; -; Genomic_DNA.
DR   RefSeq; XP_001349255.1; XM_001349219.1.
DR   EnsemblProtists; CAD51104; CAD51104; PF3D7_0827100.
DR   GeneDB; PF3D7_0827100.1:pep; -.
DR   GeneID; 2655467; -.
DR   KEGG; pfa:PF3D7_0827100; -.
DR   EuPathDB; PlasmoDB:PF3D7_0827100; -.
DR   InParanoid; Q8IBA3; -.
DR   KO; K02519; -.
DR   OMA; HNNYNKK; -.
DR   BioCyc; PLASMO:PF08_0018-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB.
DR   GO; GO:0005525; F:GTP binding; ISS:GeneDB.
DR   GO; GO:0003924; F:GTPase activity; ISS:GeneDB.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:GeneDB.
DR   GO; GO:0006413; P:translational initiation; ISS:GeneDB.
DR   Gene3D; 3.40.50.10050; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; TF_GTP-bd_dom.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR43381; PTHR43381; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52156; SSF52156; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   4: Predicted;
DR   PRODOM; Q8IBA3.
DR   SWISS-2DPAGE; Q8IBA3.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Initiation factor {ECO:0000313|EMBL:CAD51104.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:CAD51104.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN      651    899       Tr-type G. {ECO:0000259|PROSITE:PS51722}.
FT   COILED       53     80       {ECO:0000256|SAM:Coils}.
FT   COILED      484    504       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1397 AA;  164182 MW;  EF9652B6BA5A7F3F CRC64;
     MNKIKIRKFE DPHVWIYENV LLNKTLKLKE IEKKKDNKNV PNALLHEEAC KKLKGILKEC
     KKYDKELQEI KNKKESFILK NTLHPNKKIN LKFLLNDNQF KVKNEEERKN FKLIFNENKN
     IYIKNNQKVY NNIINIKRNS QITSTNNMNN NNNNVNINND NIQPTNNLLN NIKKIQKEKI
     SKLYSVFNNH VNYYDNYLKE KYMKEEYLSN VKYEYVSPHR HNYNDHDIKP DVIYKEDSNV
     SNTTHNNHNN NNNNNNNSKN KNNFSSSISS SDLLYHTNLG KNNSVSGTNL KLNVHTNNIH
     ILDNKQCYDT LHHNNAYSHD IYGNQENVNT PKDKYITKIN NKNVEDMKNV TNNIIFNKLN
     INNENTQKIF LYNRNDKEHE SIKNDKNNSK DYPFDYKKET SYLTTEENCN HIDIYDDNKM
     CDDNIYVKRN VYHNKNNSVK DLFVKSFNIL NTINQTSLYD KQNDDVSNED ANRNVLNGSV
     LSILNELREN KVKEKNKIGE YKKDNTLHKD DEKVSVSRIH TYEMKQKEVT NVNKNESFYS
     YGINNNNNNY YYNYNNCNNL KESVVPHKKK ENHKNKHIKQ YEYLDSNNIT INSLSNHLDV
     DDEKIINVCK YILDNDYIYK YTKIEKEVAE LICEELNVSE KLKFSCINLK KRNPIVTILG
     HVDHGKTTLL DRLRHSNIAD NEIGGITQKL GAFEVVCRDD EMKENKNVKE YINDNKKEEH
     NHYNKKEEHN NYNKKEEHNN YNKKDEHNNY NKKEEHNIYC DNSSNYHNRK ITFFDTPGHS
     VFRTIRKRCV QCSDLIVLVI SLDDGIMSET IECIELAKTY NTPLIIAANK IDKFHKNIEE
     LSKSLLNYNI VTNLENGDVP MVPISAKKNI NIDILKKQIL HVSNKLNLMC DYGSLCSAYI
     LEKKVDPSKG KLLTVICKSG TLKVNTYFII GHIYGKIKRI YNSNNEIVSQ AYPSEVVQII
     SSIPLSYDNI NYGDIMLEMN TLKSAQKVSK YKLKLVQYNL INDHYNMNNT LGEISRNIET
     NKNNDIHNND NNLDDNIIDE LHNDISIYDG NKKKKNSNKL DINKKYNNNN KKYNNNNNNN
     NIYNNNIYNN NNIYNIYNNN NNKYYNNHSN DLRNPLNKFN SKNNNLSGSN FNLNSFKLPQ
     IPLILKTCDE GSLEGIMEGI EHFNKNETKE KYCNIHNFID RNYINKNMLN DDINNISKEL
     FSNWCPLKII NKGLGTFHST DLKYCEHINP CFLISFNVDI DFKLLQPYIE NHNIILRNHN
     IIYELFNDIE NMCNFYFDSL HVYEPVAKMI INKTGYYSIK KNKTKKVVIS VDIKEGSFTS
     NEYFTLKRNK QIIHNKIHIL SMQKNKQNTN ELNKSCNINA IIFNINSDDF EVGDEIVAYK
     KVVRSPLFNT IKSFDLS
//

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