(data stored in ACNUC9543 zone)

SWISSPROT: Q8IB94_PLAF7

ID   Q8IB94_PLAF7            Unreviewed;      8591 AA.
AC   Q8IB94;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 119.
DE   SubName: Full=HECT-like E3 ubiquitin ligase, putative {ECO:0000313|EMBL:CAD51113.1};
DE            EC=6.3.2.19 {ECO:0000313|EMBL:CAD51113.1};
GN   ORFNames=PF3D7_0826100 {ECO:0000313|EMBL:CAD51113.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51113.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.26; Evidence={ECO:0000256|SAAS:SAAS00628607};
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DR   EMBL; AL844507; CAD51113.1; -; Genomic_DNA.
DR   RefSeq; XP_001349264.1; XM_001349228.1.
DR   SMR; Q8IB94; -.
DR   IntAct; Q8IB94; 31.
DR   PRIDE; Q8IB94; -.
DR   EnsemblProtists; CAD51113; CAD51113; PF3D7_0826100.
DR   GeneDB; PF3D7_0826100.1:pep; -.
DR   GeneID; 2655229; -.
DR   KEGG; pfa:PF3D7_0826100; -.
DR   EuPathDB; PlasmoDB:PF3D7_0826100; -.
DR   HOGENOM; HOG000282600; -.
DR   InParanoid; Q8IB94; -.
DR   KO; K10592; -.
DR   OMA; LMFIHSI; -.
DR   BioCyc; PLASMO:MAL8P1.23-MONOMER; -.
DR   Reactome; R-PFA-6798695; Neutrophil degranulation.
DR   Reactome; R-PFA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:GeneDB.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:GeneDB.
DR   CDD; cd00078; HECTc; 1.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; SSF56204; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
DR   PRODOM; Q8IB94.
DR   SWISS-2DPAGE; Q8IB94.
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transferase {ECO:0000256|SAAS:SAAS00628615};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubl conjugation pathway {ECO:0000256|PROSITE-ProRule:PRU00104,
KW   ECO:0000256|SAAS:SAAS00593691}.
FT   TRANSMEM        2380..2400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          8256..8591
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          116..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          704..761
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          803..845
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2210..2244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2809..2841
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3123..3149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3283..3331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3480..3515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4661..4789
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4940..5159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5217..5303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5380..5407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5731..5774
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5980..6064
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6148..6223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6235..6322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6425..6495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6608..6727
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6892..6949
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7338..7410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7648..7672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7741..7776
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7821..7840
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7953..7985
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8024..8043
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          8055..8150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          2511..2531
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          4153..4173
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          4852..4875
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          5822..5842
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          6122..6146
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          7192..7219
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        803..839
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2809..2828
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3123..3146
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3283..3309
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3500..3515
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4678..4789
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4940..4989
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4990..5028
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5029..5151
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5238..5303
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5731..5761
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5980..6049
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6050..6064
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6148..6163
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6164..6211
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6235..6261
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6262..6280
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6281..6310
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7348..7392
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7393..7410
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7741..7774
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7823..7838
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8028..8043
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8055..8086
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8087..8106
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8117..8131
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        8558
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   8591 AA;  1005144 MW;  76B6C5F8AFEB8B1C CRC64;
     MKIPIPKDDN FILMLDKLSQ EEKFFIHILS TCEDEHLLGH LYPFVDWVWL KSDLLAWAPV
     LNRFDDLLRK YIIHNKLVMQ KKNNKNGDNE GSDYIVMNDR IQRITGCTLE YNYNNYNDNN
     DNDNNNNDNN NNDNNNDNNS NNINSNNNNN NNNNCENINL SCQSTCENGK KEFIPSDLLV
     EEILRFTYNI LDNCLNKTKY NSIEHLILLL WSFNPKLSIL CAEILNIYYL FIKKTKKNET
     KINEIVNFVS SIINIPIPDH LHPYINNDIG RINDNNYISG LVLYYLHDKT NEQYMKNIYN
     KVENKYFLDL IDYNIDLQKI NINVNNIDIS FTSLFPTHIK YNETQNILNN AFNYIMENYN
     IPEQYMYDVR HKLRIYVGLI CPKYRRKLFN LRYLILSGSL SINSIVSPQI VTSNSIFLEE
     LLYFLKYHKY VHFNTLRIIF DLLITSIESH LYYKVVSDIL GLRLHSGLFI SIFKYYLNYF
     LSPYTLQKDI CPLYVMNESE REVYSINDIN EYYIRKANPN IKNSLYSKED TGHVYMNNDN
     TNNKSHNNIN NNNIINSNNN LNYYTLSDND ILMNILRDSI PPHMMNMNNS EINSLIQASQ
     HISNNNNYFN LVNTSVSPSQ EQYFTPRAYT QEQNVNNLNF NYNGSNLMNQ SSIMNEQNVF
     SSIPLETLGV IEANQMQNLD SSNVLNSSGT SVDMNIRSSE VTSLINNNNN NNNNDNNNDN
     NNDNNNDNNN DNNNDNNNNN NNNNNNNNNN SNNSSVFTFG SVNNQGESVS AIDNMNIFDY
     INNTPNMIND NHLNILDYIR HSQSNNNNND NNNDNNNDNN NDNNNDNNNN NNNDNNQQSE
     GNTEKDEIKY ENYISEETII NNIKNCKKNG ENEFFKVTKS YFKEFRKKKK HISMMLQLLT
     LYHTCIMEPC PILTIAQQNT LKIFPLFLLD SSTHNLPIVH LLLRIMETLL DFTPNFYFTV
     KDEEELYKIL LSRFQYEFFL MSDSFYHLNR KDYLRYYFEP FNYEGYDQEF IETNEQKEIY
     IKRKREEYFN YVNRIQDLCN MKNMNNSDNI RNACVNIFGG IGPNIYNGIN NLTDVCIKNV
     IYNNDNNNDN NDNDIDIDNS TDDDDDDDDN IWNVECYDDK TMFSIKDKLL KSLFERYDVN
     VKVTDEVLLN RFNFWIKLYI YQERMKIIKM IIKALNLALK GYSPTDTLLD IFTNNYISVK
     IIKYILRFPH KFGLCLYGYI LGFIYEHIYE DPTILSTLLK EGILHIMLNG IVEQNLKDET
     VLIYVPSLLS LMFIHSIGKS TMKKINYTPI YNLFHFVIQR DYFFFDRFGD IAVSVGNIIN
     ELENYGFVMK DFLIFHVKLL KNLLIKGLKL GYWKSIDYDY IEKHVDNSIK QLQDMQLKDL
     NLNRYKYRKD KFLLDRLSIL CRFILSYMKT SWIKNFIHFN GLKILMTFTN LPCFPPNYIH
     IFEYHPIYSL IMKIYLYASF KSLYNQFLYP LYNFTNFIMY TQYVNFILNN KLIFDLDTNI
     VVVKKDELRN ILKMEPNTNN KHNTNSCNNI HNNRESENAY KDLNKHKKNS YKYHMDNNKY
     LKKGNFCGPY IDRNKLLLTN ITHLFNILYF LISAYTDAKG LYGNEEKLYD SPEISNRKIL
     EVFSDVLTSI ESVFDFFFTL YFYQTNDLNN TIVLPLKDKI CIHEHVKRTI RNNQNKSDYL
     LYNLFGCTRS LYCYSVNNNL YDMTNKDKKI HFLCDEDNYV NDYKFIDSLK KIDNDDKVYK
     AIYKYAFSHV ISEFHKYQNK NCKTPSDITN YRKAEKSKFK RYFSNSEESI KRSLRKSNST
     NPAVANHVNN LTKNVESIIN NNNINNNNIS NNNNNININH NTISSNNNNN NINPFNNIQA
     DILCNTDDSG NFVDFSKLYN IYNDRCQQEY KNKLNHRVNK DNKSEKCKKY NDYYIDDKNI
     HMHTNYPYES KYVMCESLKS LLVVIKKFFI MINLACHTRQ LKMKTSPNYI FYNVIQQKHI
     LCIIRCITKC MMNVPLVSKP IQENSYLERN HIYHILSDHI TQDKINYLNK LNDKKNKTNI
     HMSKNVCKNY IRKMSRDVQD NNLIKSENGN NVSTNNISFD MNHNNMMDQN KNSSIDYMSN
     NINVNHYMYQ TECKKEDKYF NLYDYSYTPY MNYNVENIEG IYPETFYMEE ILFKRYNFNF
     SNISVTTNKQ IYHNKYSNKE NCVNKNMSHV EEDADELFVM DSINNCNNMN VDMNNSNDNS
     DNNNNNNNNN NNNNNNNNND NNNDRCVDSL GGDFNHINNF SKYNKTYICN NTGNIKGLES
     IDLNNLINII NNKNKTLNEN NCDSKNYEGK EKNELKKNKF NEKKMEQVSI HIQDYTPIKT
     IKYISEIINI LHKLLSDNKL EFVSYFYFLD LLYKVGTFDF IFNMFNYVMS VYISLLSLYY
     KKKKENKQNC CSKFTSYIPI HVSRNYTCTN TYFVRYIIRL MLYYADSDVN TIKTYLQITV
     KSINTFLDFF ISLINIGKFN MILFCSKMLH PLTKIHNHFE GQRVDPNVNK KENEEEKNVS
     TNSEIKVKED NDKINGHIFN NNTNDIHNNN NNNNNNSGIS FDNNINNLSN ECISIQNNTN
     PNYEGINMNS GFSNISNISN TQNFNNTNES LNYDNKINGD QNNFCTFEKN HINNIKEVKD
     SNNENNTFSY NNNFLFSLDY FDILNTIRSV KCDISNNIFM WLTYINSTSV KIGNLGRNNI
     YINFSNTIIY NFLKIILKFI HHSTEVEPKL NELWMKEKNK EKKNVGNKDK EKDAFNYPNV
     NILEEWGLMG FDEKTIYDCL NYSGTTDLDC TLNYLDKAKE KEYFSNMSMD KSMSEKKKKN
     KDNLKSSYSE FDDNSSDSFS SASNRITDDI IISRNIMQCR EYNNNLNDMI TQETINNNSN
     VFPLTINNNG SNDNNNNDNN IYGDSCNNNI YHSNNKLDEE KNEDIFYKDD KYILEKFPFM
     FDLLKEAQKK SVHARIYYYD NIMNPNNKRN MIFYIQYYLK SLRKNTFNSY EQKNYIKAFW
     NEEKYLLLKQ YIYKYIFNML INIMLTIPYN EISFMNLYLS FLIIDIDKKT VKLFLDQYKK
     TIHDKNSNKS RIFNHQDVKI IILYYFIENI SKKIKTLKND EGIPYEPFYH CHHMFMNLHK
     KKNKGLKNSD DSTKQDKKKD NKNIIQNKLP DARNIQNIYN SNCPISSQNN NRSNNIITAT
     SPNITLNIST IPNDNNVNIF NNNNNNNNNN NNNNNNIIIS VHDINPSTNI HVNNNNINNL
     SVVNTNNNML NINHVNNNRN RTSNTIENNV LLHYPLNNLD NSYHSDDNPF NAYQDNNNNN
     NNTNLVDDKN GNKNNKDYQD KKILTNSPDT LNNDLNDEKN CIYGTKYAKG DIDVIYESQK
     DMEIYSYHFC LYMLFFTLYN VLHKYNIAKN LILNMDRNIL DYCIFFIQKF NISYIKCIEN
     NVNYFLALVK NERKIDNQEH NQKVKEQHHV EQRQSVFLND VPSCNVINVE NVDMNLNEQD
     LISKKNQEKN KRKRKYNKIL SQSKGNTNNL DPSASSLESA DKIMVSSSLE IDGNIITNKM
     IHNHNNNNNN NNEYNYMGCC NNNMNEASIN LNNDANNILK IHINNNTSKN LNNPICDNHI
     ITSTNNVISD NEMKKEKINI MYNKGLVINK NLETHNMLIP YWNLADVDSS VSLTKTETNN
     NLMVENEENK YISLYSKPPC FYAPLFMCLY KIIINYSLYN FNDKNKKTNK KTKEEKYSED
     KNMFLNNLKM EHYSMLNKNN THINKSEKVF NTNEKRINVT VGTSNYNLSN NIKLPQTHME
     NVRYVSTEKQ HNIIKICIDT LYFFKGYNSH LCLSILSIIE YLTTTYNNVV FFITYSPPNI
     YKDFKKVFQI EEQMRQMNRR KNLNQNDDNQ KSFDKFHVNN NVIINASTKK AKEELISNND
     INVEKEIHKN NNNDNNNDNF NIPPFYSVDG FKGENSNFYE QKLSYFDLND LILNNMSRNS
     LGIILSISKQ VKFKDMLILL ISILLQCFTD NYVIANRMES NLKSYFASHG IPVKCFMKKD
     DLEVIENPKF ANALGVSLSE LNEALYPFIF KNPQIYEDIL SCLCFFPNLK YIKKSETNDL
     EKFGINTNVD DTYKFLEEKK KKLDPIGQVN TDKKKSSNFV MSTNDNVNFD MNIEYNNIIN
     PSNNMNLQDF TKIDSLKNEG EKIKETNKNE ENMNDIYNNN ISNNISNNNY YLNILPIPEH
     IKSIYMLSEV AFSPRCLRKY HVKNNFYNFY ILATLLDFLN LFTIIQSKTR LAKLSGKEEK
     EKFNKALMEI YGTDADFDNE LEYKVMYPFA LTADNMLFII NLLLKTYKHL IVYLIKIPAS
     FNQKIIKSFF QKEYGMYHFR GSMLYVDNSS FPYNDIAINK ESRLSNFSSI SNFSITSKNK
     NNTDINVNNN TNDDSAIYLL TKNNDENNKN EYPIMDLSNV LYKLIRCDSV NTHTYKQISE
     YYLQNYMQYY SLFDLSNFTF RSCLFPFIYE KKYITDIHNM DLINYVSNIN NSHNIVFTPF
     LIFLFKRILP QFICLNYPSL RSPYSLNTFK KKYPNMEKYY ALRNNENKNL TYLRHIVNFI
     QLIFDIHNAN YDIHKKVVLE IIHLLKIHSN FQKKKDNVNK NIKDNDHVFS NVMDIFTYAI
     SSLLYKMVNE EQNIKIQKPP NVEDDQCINK KKKVSEQFQL HQKGNTKKIK KNDDSDYSNA
     DTFTFNNRDN NNDNDNNNNN NNNNNNNNND DDNNNHNNNN NHNNNNNNNH NNNNNNHNNN
     NNNNNNNNHN NNNHNNNNNN NNNNNHNNNN NNNNNNNEDG NGENDDNNKT FYYNREQLIM
     FRHSLCNLLN KLDYSKEDFS NVATSIIRCL SVLTSAPVMG YPIKTKNNKL FMIKLNKLNE
     KKNTKIKKIK RNKRRKNVSY VTFLNPSYVR FRSDSSNNDS ECSDIPYSDD SDISYEEHFI
     FDNGESDEED DDIRYEYEEE MDDDYMEEEE IVNQEDGEEE DEEEAIEGED DEEAQDEEND
     EEEGNNENET LFNDEYYNQT DNNNDNDNDN NNDNNNDNNN NLLNDEENND MSNNDEENDV
     ERDDEDVEGD DDEDVEVDDD EEVDVDEDEE EVDVDEDEEE VEEMDDDMEN EDDDEDDIDD
     DDDEDDEEDV EDDDEVDDEV DDEVDDEVDD EEVLDDEYDE IDIEDEDAAE RNSNEVNDNN
     RNVHVHAYLV QDRNEIDEDQ IYDNSNDLLL PHEVDENEEI LSNMDDNNNN IVSRLDLVSD
     SSNDMDEQNV HRIREIDETE EDEEDDDGED DEEDDDEDDE EDDDEDDDDE DDGEDDDEED
     DEEDEDEGEE EYEDVEEEDG DEEELHINNS TYNVNQNVDN IRSNNNNTDL IDNEINVNNS
     LLNCNENQHE ILDILLEEDG AYNINDDIDE YNDDYVDEVD NNNNNNNNNN NNNNNNNNNN
     RSNNNSFSNI VNIDAQNINN NQMRNRMNTT NDIGHINNLQ ENINTNHMNS TSQYNMNGNI
     SNICNNTFAG QKSSSNERDV LENNVNNSII IHNENSTHDH HINSSLLDNN KNQNISNNIS
     MIHNSTIETK NNILPNALEN NIHNNIDTQN NLCNNVNANS CSNNIYANTQ TKSEKKGTIK
     NGISLENNEE NTNEHINKNN VIVGENYILN NKIKNEQINN TKVKNDHIID SNINNINNIK
     NDINDNIIKV DKNNIKNNDS FAVKDKSMLE SSESTTNIRN VDENNVSIID LYYHFYGSNN
     RDINTLLNEN NSILYLNETG QINSTQIKET NNKINNNNNN NNNNNNNNNN NNNNGNNTSV
     DNKDSKKTDK SNNTNDAEQV ALQLNNNNTE GVEEFNNITS LNIENLMDQL YSTLLSTDIR
     TNDLLNNEII SLQNIANRVQ RNNDFNNIVD ESSYNIIGDD ITENRNLYDN RLNRNNSVPY
     IHRNVERLNN FPPLPTSNNN TNIRASWNNR NINRPNSITN NVVNNSLNNI TSSIRNNNLR
     NIFNNIRNNN NNENVFNRHR TINIVPSIIR NDIIQNLSAS HQNNRDPNSS SSSSNNNNNN
     NNNLTTNRDT NNTNERTNEN NNIHNNNNNE NDNNNNISQT RVNNNDQRQV SDLNKDKNQI
     KDKGSKIEKT EMLTKKYNKN QAQFNMVDAV IDNDTILKSA ICNRMYNRLC KAIPKVHIKL
     PLENLIEEKK RIIQTLKKQK EQEQLQENIK GNDNNNNNNN SNKEHQNELE DVNKNKGDQN
     KKDKKGNKDK KLSRFTTTTN DKKKNTNEEN DIIESNENDN ITNAQLGSHN EQLENTELNN
     DNNNNNNNTN NGFNPNEGDN DSDSDSNSDS NSDSDSDDYN DNSDNNNNND NNNDNNDNNN
     DNNNENQNNV NNDEDHLEEE NEEDYKNINY EELFDNILNI ESLLIICCSL GISESQFLEL
     LNVDRSFLIE LPSNLIDELI IQHLKNITLT GISEKAQDNI KNKKIISIKM YKNYLKYQEY
     KKSQENNASN ENNTNDILNN TTGNNITNDN NNNDNNNNNN DNNINNNVSS ANSTTNNCAT
     EFNERPNNEN SSVIQNLDNN TNIQNNINDE KEQNIRIFNS IKKSYLEALP SSIRSEIKKR
     IIGNRTERTD VQDETNISFI DSLTPELRRD VLSTASIRFI RTLTDDMIEE ARNLRLVILN
     NRNSALNANN RNRQNVSNND GANTTATNNR SVSDRNAQNM NNISNTNNTS TVNDTNNTNN
     VSNVSNVGNT NNVNSVNNVN NVSNVSNTNN MNNNNNNNNN NSISSSSNNN SSSSSSNITS
     TTNRNINGSN VANLINNIRN NIQVRISNRA LRNVSNNLNN SNHNHNNINI INNINNINSI
     NNMNIINNNN MIVNNFNRSN RNSNRLVFTG GNRNNLNNRR RLNLPLRNSL SNMQRNNFIR
     ITYNENNAPV IMINTGHENY DSLTVTRFID NIMGIRTHDA LASGLPIGDS NNSSNYNNNS
     NNNNNNNNNS NSNNNNNNNS NNNNNNNNNN NNNNNNNNNN NNSNSNNERS RLFMSNQNRN
     VHHNNNVDHN YHVMNDDKYL EKEDDMLLNR YLKNLFPSMN RFNTDNSKTS SLYICVEEPV
     PFQALIDICR LLFLKKEINK KIMFTLFCNL TCSYQKTKVY TLQLFMNILW CASADLHAKK
     NNPSIVYLNS INFPPKMLYY NMNKKHYGLF SDNYFITASI SAERVLEQVQ SLLITVPHIS
     SFFCTFLIHP SYFMPNDLDE NMITNNDKGN ETNINQGNHN FMDVPYYGDK MIKNEKTDGE
     KKNNEIINYQ KEKDVEEEKE YDDEAVILEY ELKRKRPKMD EKKKQKNQIS DIYKNKTNIN
     DKISTQVDMS KYEYPINILF KLLNSSLYLT SKKLMSHLLS VIYNLLINCA KKNHNYANFT
     RWVYEENLEE IISMENENNE EEVTSDDNNK NNNNNSSNNN NNNSSNSNNN KMSNDRNGTN
     PERNVSCTNK ENTNKNKDTK QKQNKEKENF LSSTKIDKEL LLNIKSLKPI DEEIDKKDLI
     SKPYYLLEVI SKDALRNLSK LICNYKTNFL WINNMNNTTN NNNNNNVNNN LEQVHKQDIS
     SLIQIMVMFF SHYKLKDLIV QSLKRHTHVL IKRIIYDLKK IVHSIHNKTF NIYSVDHSDS
     LEQKLIAFYR VITILFNAPT LIDSITNKND LNKSDTINLN NTNNSISNVE GVNTPVQEND
     HINNNISNEN DCNINIMNNV PNNNNQDNIS SEINTNETNN NKSFVNNNDM DNETIKNDYE
     KHINKTRVDE ETKFDICADF FLSINIDLLW EEFNKTMQVI NNSLIDKNYK FKDNYYYKDL
     NTTKDDNKKE NNNDKLQTGN VHKTNEKEDK NISNNLADTQ DNNIVTLFNT DSSSNDCSDH
     GDIYSNDRLS SNIQNEEIIT NVENENNDEK KKENDDEPPP TILNYLLPLM EAYLFIEEVI
     LVSQYKLRKF KDLEKKVASL NVESIKINEK LAYDDSPFYI NIYNKKKMMK KKNKKYKSTK
     ELLLDIFDDS HINSDPTNLN KIKRKMCTNK LEQQKQKQEE EEEEEEEDDK KKIQNNYTHD
     DSMNNNIVEN ENINECINQN TNEKDHVEGQ DQLVRNKLKK KKLNEDQTND NNNNNNNNNI
     QQLNKREEMI VCGNHDRQEK PNDKENKNKN KNKNDRNNEQ LDSNVNHDNV DENNTNSFYN
     KISNEQSNHK EVQEYQDSDI YDDDNDEDVD QYGNYYNEGK DDEEEDDDDD NDEYIQIKLE
     DNEGTINSRH KKLIKFVYIN RRVINSLIKQ TPILLHHNFK SLIKLTSSCI NFENKRHYLR
     KKLKYLKSGI RSDPIRLSIR REKVFTDSYY QLRNKSGNDL KGKLVVTFKN EEGVDAGGLT
     REWYSILAKE IFNPNYALFC REGKKSEFNH PNPLSYINPD HLHFFKFVGK FIAKAIYDGQ
     VIDAYFCRSF YKHMLGRKIL PADAESVDPE FYNSLIKISE YKLEDLNLEI NFSTEIDEFG
     KTKVIDLIPN GRNIPVTDEN KHKYIELLCE LKVTNSIKEQ LEAFMDGFKE LIQPKLISIF
     DDKELELLIS GIPTIDLNDL KENVEYHNYT ANSIQIIWLW DVLQEFDENK KASFLQFVTG
     TSRVPLGGFK NLMGMRGAQK MIIYKAYGED RLPTAHTCFN QLDLPEYSSK ELLKSKLIRA
     IMEGKEGFGF I
//

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