(data stored in ACNUC9543 zone)

SWISSPROT: Q8IB73_PLAF7

ID   Q8IB73_PLAF7            Unreviewed;       318 AA.
AC   Q8IB73;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 109.
DE   SubName: Full=Dicarboxylate/tricarboxylate carrier {ECO:0000313|EMBL:CAD51134.1};
GN   ORFNames=PF3D7_0823900 {ECO:0000313|EMBL:CAD51134.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51134.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29)
CC       family. {ECO:0000256|RuleBase:RU000488,
CC       ECO:0000256|SAAS:SAAS00548220}.
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DR   EMBL; AL844507; CAD51134.1; -; Genomic_DNA.
DR   RefSeq; XP_001349285.1; XM_001349249.1.
DR   SMR; Q8IB73; -.
DR   TCDB; 2.A.29.2.10; the mitochondrial carrier (mc) family.
DR   SwissPalm; Q8IB73; -.
DR   PRIDE; Q8IB73; -.
DR   EnsemblProtists; CAD51134; CAD51134; PF3D7_0823900.
DR   GeneDB; PF3D7_0823900.1:pep; -.
DR   GeneID; 2655481; -.
DR   KEGG; pfa:PF3D7_0823900; -.
DR   EuPathDB; PlasmoDB:PF3D7_0823900; -.
DR   HOGENOM; HOG000165139; -.
DR   InParanoid; Q8IB73; -.
DR   KO; K15104; -.
DR   OMA; FGAYEVG; -.
DR   PhylomeDB; Q8IB73; -.
DR   BioCyc; PLASMO:PF08_0031-MONOMER; -.
DR   Reactome; R-PFA-70263; Gluconeogenesis.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IDA:GeneDB.
DR   GO; GO:0005310; F:dicarboxylic acid transmembrane transporter activity; ISS:GeneDB.
DR   GO; GO:0015367; F:oxoglutarate:malate antiporter activity; IDA:GeneDB.
DR   GO; GO:0015742; P:alpha-ketoglutarate transport; ISS:GeneDB.
DR   GO; GO:0006835; P:dicarboxylic acid transport; ISS:GeneDB.
DR   GO; GO:0015743; P:malate transport; IDA:GeneDB.
DR   GO; GO:0006839; P:mitochondrial transport; ISS:GeneDB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
DR   PRODOM; Q8IB73.
DR   SWISS-2DPAGE; Q8IB73.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Membrane {ECO:0000256|PROSITE-ProRule:PRU00282,
KW   ECO:0000256|SAAS:SAAS00013463, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00282,
KW   ECO:0000256|RuleBase:RU000488, ECO:0000256|SAAS:SAAS00423777,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00423880,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000488}.
FT   TRANSMEM    228    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   REPEAT       29    116       Solcar. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00282}.
FT   REPEAT      124    215       Solcar. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00282}.
FT   REPEAT      222    313       Solcar. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00282}.
SQ   SEQUENCE   318 AA;  35387 MW;  3A4D7935719271E5 CRC64;
     MDRDIAKYDL ESSSSVDVNK KGNNNKSVFE KIKPFAVGGA SGMFATFCIQ PLDMVKVRIQ
     LNAEGKNVLR NPFIVAKDII KNEGFLSLYK GLDAGLTRQV IYTTGRLGLF RTFSDMVKKE
     GEPLPFYKKC FCALAAGGLG AFIGNPADLS LIRLQADNTL PKELKRNYTG VFNALYRISK
     EEGLFALWKG SVPTIARAMS LNLGMLSTYD QSKEFLQKYL GVGMKTNLVA SVISGFFAVT
     LSLPFDFVKT CMQKMKADPV TKKMPYKNML DCSIQLYKKG GISIFYSSYA TYYVRIAPHA
     MITLITVDYL NNLLKKIS
//

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