(data stored in ACNUC9543 zone)

SWISSPROT: Q8IB55_PLAF7

ID   Q8IB55_PLAF7            Unreviewed;       234 AA.
AC   Q8IB55;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 82.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 7 {ECO:0000256|RuleBase:RU364060};
GN   ORFNames=PF3D7_0822100 {ECO:0000313|EMBL:CAD51153.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51153.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator
CC       involved in the regulated transcription of nearly all RNA
CC       polymerase II-dependent genes. Mediator functions as a bridge to
CC       convey information from gene-specific regulatory proteins to the
CC       basal RNA polymerase II transcription machinery.
CC       {ECO:0000256|RuleBase:RU364060}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364060, ECO:0000256|SAAS:SAAS00869477}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364060,
CC       ECO:0000256|SAAS:SAAS00869478}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC       {ECO:0000256|RuleBase:RU364060}.
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DR   EMBL; AL844507; CAD51153.1; -; Genomic_DNA.
DR   RefSeq; XP_001349304.1; XM_001349268.1.
DR   SMR; Q8IB55; -.
DR   PRIDE; Q8IB55; -.
DR   EnsemblProtists; CAD51153; CAD51153; PF3D7_0822100.
DR   GeneDB; PF3D7_0822100.1:pep; -.
DR   GeneID; 2655488; -.
DR   KEGG; pfa:PF3D7_0822100; -.
DR   EuPathDB; PlasmoDB:PF3D7_0822100; -.
DR   HOGENOM; HOG000282636; -.
DR   InParanoid; Q8IB55; -.
DR   KO; K15148; -.
DR   OMA; IRLYKMY; -.
DR   BioCyc; PLASMO:PF08_0037-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR009244; Mediatior_Med7.
DR   Pfam; PF05983; Med7; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8IB55.
DR   SWISS-2DPAGE; Q8IB55.
KW   Activator {ECO:0000256|RuleBase:RU364060};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Nucleus {ECO:0000256|RuleBase:RU364060,
KW   ECO:0000256|SAAS:SAAS00869474};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transcription {ECO:0000256|RuleBase:RU364060,
KW   ECO:0000256|SAAS:SAAS00869482};
KW   Transcription regulation {ECO:0000256|RuleBase:RU364060,
KW   ECO:0000256|SAAS:SAAS00869473}.
SQ   SEQUENCE   234 AA;  28197 MW;  943626D424A24E66 CRC64;
     MADENYVSGY PPPPYYYKEY QSVDIKKLME MSNFKSTDEK SFLEHMKNSY DVIYDVDTNT
     YIKNIESIDN IKNCNFIMGR PPPLPLRNSY NVFGIDYELQ RNIEELDSDE ILYDEKKNLK
     EEFIRLYKIY KETFFLLFDD IVNNRKDDKS KIKHLTKIHV NLFHILAKLR HYQTINNIIN
     VLKIQLKKRQ IAIDKMKISL LNVYQYINFV QTNYGNNKMI KNEENQEKKN KKKN
//

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