(data stored in ACNUC9543 zone)

SWISSPROT: Q8IB50_PLAF7

ID   Q8IB50_PLAF7            Unreviewed;       674 AA.
AC   Q8IB50;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 81.
DE   SubName: Full=Polyribonucleotide 5'-hydroxyl-kinase Clp1, putative {ECO:0000313|EMBL:CAD51158.1};
DE            EC=2.7.1.78 {ECO:0000313|EMBL:CAD51158.1};
GN   ORFNames=PF3D7_0821600 {ECO:0000313|EMBL:CAD51158.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51158.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00533943}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC       {ECO:0000256|SAAS:SAAS00533944}.
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DR   EMBL; AL844507; CAD51158.1; -; Genomic_DNA.
DR   RefSeq; XP_001349309.1; XM_001349273.1.
DR   SMR; Q8IB50; -.
DR   EnsemblProtists; CAD51158; CAD51158; PF3D7_0821600.
DR   GeneDB; PF3D7_0821600.1:pep; -.
DR   GeneID; 2655491; -.
DR   KEGG; pfa:PF3D7_0821600; -.
DR   EuPathDB; PlasmoDB:PF3D7_0821600; -.
DR   HOGENOM; HOG000282639; -.
DR   InParanoid; Q8IB50; -.
DR   KO; K14399; -.
DR   OMA; TGCTIQI; -.
DR   BioCyc; PLASMO:PF08_0040-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IBA:GO_Central.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IBA:GO_Central.
DR   Gene3D; 2.60.120.1030; -; 1.
DR   InterPro; IPR032324; Clp1_N.
DR   InterPro; IPR038239; Clp1_N_sf.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF16573; CLP1_N; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8IB50.
DR   SWISS-2DPAGE; Q8IB50.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00311975};
KW   Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:CAD51158.1};
KW   mRNA processing {ECO:0000256|SAAS:SAAS00311768};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00494490};
KW   Nucleus {ECO:0000256|SAAS:SAAS00311767};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transferase {ECO:0000313|EMBL:CAD51158.1}.
FT   DOMAIN          63..128
FT                   /note="CLP1_N"
FT                   /evidence="ECO:0000259|Pfam:PF16573"
FT   DOMAIN          143..178
FT                   /note="CLP1_P"
FT                   /evidence="ECO:0000259|Pfam:PF16575"
FT   REGION          611..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          207..230
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          352..379
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        611..627
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   674 AA;  79061 MW;  1765985CCBD4904E CRC64;
     MANNGNTRLY HLKAYHELRI VTLEKSTKYN EKEECIKIRI LSSKNIHHKS NERKNPTDNI
     NYSAEIFGKE LILDKDYTFG YNEKFSIYTY TGCYIQIKGI TLQEYESKNN TMKEYVSLCY
     ILDAYRKLAK KKKKIGPRIL ITGNNNSGKS SVSLLLLNYA LKSGFKPLYI ETDTKASSDK
     VELNRGPGVI SCFKYDNMNN IVSMYPMASL NNINNNINNN NNNNNNNNNN SNNVELVNNN
     NTINVNNNMF DSYMKYSLEY FFGYYDIKED LNLYYHLNEC ISSCIYLMFL NNINNESTDL
     RNYSNEQEHI CSSGFILNVP SEADHEIVQN MIDIYNINIV IIIDNSFLHY SLKKYYHNIN
     EDQQEYNNVE KENNLIKDRD KKSKQTNRLS EHNLLYDMNV FNDKDVNPDM RGSTVFTKNK
     GEDGFYDDQK NEELKRGNYN NININNNNNN NNYYYNNDNV NNMYNMMYNN HQEDEEKKNI
     QIIGMPKFEG VIPSDNNRIK YCRNLWYYNY FSRDININNY AFKKSHILSF KYSRTNFVKL
     DTNLAVPLSA LPSDCRDIKR ENVSVSLYNG NVKNLINCIL AVSYSKDFTY VHLINIAALI
     HVQGIKEVEK TQQKQDNEKD KEKENNNSYV NQDGNNTEQH QVDYIFDILC PTYITLKNLP
     PFFIIPGNIR QMKF
//

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