(data stored in ACNUC9543 zone)

SWISSPROT: Q8IB25_PLAF7

ID   Q8IB25_PLAF7            Unreviewed;      1313 AA.
AC   Q8IB25;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 79.
DE   RecName: Full=Cleavage and polyadenylation specificity factor subunit 2 {ECO:0000256|RuleBase:RU365006};
DE   AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit {ECO:0000256|RuleBase:RU365006};
GN   ORFNames=PF3D7_0819000 {ECO:0000313|EMBL:CAD51184.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51184.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365006}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC       RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1
CC       subfamily. {ECO:0000256|RuleBase:RU365006}.
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DR   EMBL; AL844507; CAD51184.1; -; Genomic_DNA.
DR   RefSeq; XP_001349335.1; XM_001349299.1.
DR   IntAct; Q8IB25; 2.
DR   EnsemblProtists; CAD51184; CAD51184; PF3D7_0819000.
DR   GeneDB; PF3D7_0819000.1:pep; -.
DR   GeneID; 2655390; -.
DR   KEGG; pfa:PF3D7_0819000; -.
DR   EuPathDB; PlasmoDB:PF3D7_0819000; -.
DR   HOGENOM; HOG000282660; -.
DR   InParanoid; Q8IB25; -.
DR   OMA; LINCGWD; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   GO; GO:0016180; P:snRNA processing; IEA:InterPro.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR027075; CPSF2.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR45922; PTHR45922; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8IB25.
DR   SWISS-2DPAGE; Q8IB25.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   mRNA processing {ECO:0000256|RuleBase:RU365006};
KW   Nucleus {ECO:0000256|RuleBase:RU365006};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   RNA-binding {ECO:0000256|RuleBase:RU365006}.
FT   DOMAIN      317    436       Beta-Casp. {ECO:0000259|SMART:SM01027}.
FT   COILED       24     44       {ECO:0000256|SAM:Coils}.
FT   COILED     1130   1157       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1313 AA;  157676 MW;  898E151CC58973B4 CRC64;
     MLIEIVPLYS NSFYSTLLII KDFNVLKENE RISLKDNLNE QNENQSSDKN VSISSVENIN
     VENYNCEELY KYDYVNNKRD FYNDRKDNNI YILMNCGWDD KFCLEDIKNV IRVCEVIDLI
     IITNHSLNYI GSLPVVFMEL LKRKKKVPII CHEYIKSYSK YILLSYLKCN YNCEYFKNFK
     ENEYIELINN LYENIIILEY MEHYVFKKVI CKKTNIEYIL PLYLINNGDN IGSSAVILKL
     FNNKILYSIN CNLEDYSFIE KSHVIKESNI FTYISNFHYS NKNSTKMMDM KNILNTINKT
     IKKMGCVLLP VDIDSIFIDL LFHINALLEV CSQRYMLLFL CPYGENFIRL LFTSLTYMNV
     HIKNNFHKNR INLFKIKNLI CLKNYNDFKK YEDAYYILFS FPSTLNNESV KRILSTFLKK
     EENVILFTKE QTGQENMSSN LWKHVSCNEQ NKEKEKTSHF NFSYVQNIKY DDKMLYDIYL
     KEKENIQNEI LQKKGEEKIK KKIKRSVKKN KPMNFIFESH EEMLYLKKEN NFVDKKKEIK
     CKRDFWEDNK DKVVKSEKND DDKDDDKDDD KDDDKDDDKD DDKDDNNDDN NDDNNDDNND
     DNNDDNNDDN YNDDDEIYDE SSNSSNSNDY EDENYFLKGN KKKKYLYRIN TFNEGDTSDD
     GDNQINDINK LSDNNESEDD DFNHLIKSKD DNRKKKNKQK IYRDFPYQNV NNHNDDANSS
     ESIIDDEEEY YKKEVVEDVK DGSLKNQNKK KVRIKMEPMN DDNDNNYVEE EEYKIAGVHE
     KKLRSNIKKE LYFYDNMEQN YNQNEDDYND DDYNDDNYND DDYNDDDDND DNDDDNDDDN
     NNEEEKHEYV KKISGDKNKK RNKNRSKTNY HYDNYYNMKE NLDESENMSD YYNINKGKHI
     LNKGSTLNNT FDTDYKHQNN RHMINKKMAW KQKLFVYLKK IPTQEKQQHV SIPIECLIEL
     YNLENYINQN TLKTIIQFMK PKHFVLLPTY NSYYSFHLEM LLHSSISTYD YTKIYSFYIP
     NFYYTDNHNE VFFKRYFSLN NKSIDSVHIP LNMNYENIYI RSIYNLISSK NCQDDKFQIY
     KIKATISDVS VKNKKDVYEN YRRRKRFINE HSTFWSEYND VNYILKLGDD EKYDEEKEDK
     EENIPSEEKE KENEKSNERR FLNFYIDDDK ENEEDESDED SIDFSDSCLS SDRQECILSK
     DMNEENNNKI EGNLYIGDVN MQNLCTNIHS VFNRSLNFVD ENQIIINGNT CVKKEVQTKV
     QNQNQENYED KENFKKQDHN SNSNFIWRIE SSLDPTFYFV RNILKDMYNN VSI
//

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