(data stored in SCRATCH zone)

SWISSPROT: Q8IB03_PLAF7

ID   Q8IB03_PLAF7            Unreviewed;      1070 AA.
AC   Q8IB03;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 130.
DE   SubName: Full=Chaperone protein ClpB1 {ECO:0000313|EMBL:CAD51207.1};
GN   ORFNames=PF3D7_0816600 {ECO:0000313|EMBL:CAD51207.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51207.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000213|PDB:2P65}
RP   X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 311-496.
RA   Wernimont A.K., Lew J., Kozieradzki I., Lin Y.H., Hassanali A., Zhao Y.,
RA   Arrowsmith C.H., Edwards A.M., Weigelt J., Sundstrom M., Bochkarev A.,
RA   Hui R., Artz J.D.;
RT   "Crystal Structure of the first nucleotide binding domain of chaperone
RT   ClpB1, putative, (Pv089580) from Plasmodium Vivax.";
RL   Submitted (MAR-2007) to the PDB data bank.
RN   [4] {ECO:0000213|PDB:4XBI}
RP   X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 152-298; 300-352; 427-496 AND
RP   513-586.
RX   PubMed=26130467; DOI=10.1002/pro.2739;
RA   AhYoung A.P., Koehl A., Cascio D., Egea P.F.;
RT   "Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting
RT   protein folding and secretion for antimalarial drug design.";
RL   Protein Sci. 24:1508-1520(2015).
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DR   EMBL; AL844507; CAD51207.1; -; Genomic_DNA.
DR   RefSeq; XP_001349358.1; XM_001349322.1.
DR   PDB; 2P65; X-ray; 1.70 A; A=310-496.
DR   PDB; 4XBI; X-ray; 2.01 A; A/B=152-298.
DR   PDBsum; 2P65; -.
DR   PDBsum; 4XBI; -.
DR   SMR; Q8IB03; -.
DR   PRIDE; Q8IB03; -.
DR   EnsemblProtists; CAD51207; CAD51207; PF3D7_0816600.
DR   GeneDB; PF3D7_0816600.1:pep; -.
DR   GeneID; 2655262; -.
DR   KEGG; pfa:PF3D7_0816600; -.
DR   EuPathDB; PlasmoDB:PF3D7_0816600; -.
DR   HOGENOM; HOG000218211; -.
DR   InParanoid; Q8IB03; -.
DR   KO; K03695; -.
DR   OMA; AYEAHHQ; -.
DR   PhylomeDB; Q8IB03; -.
DR   BioCyc; PLASMO:PF08_0063-MONOMER; -.
DR   EvolutionaryTrace; Q8IB03; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0020011; C:apicoplast; IDA:GeneDB.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATPase activity; IDA:GeneDB.
DR   GO; GO:0019538; P:protein metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1780.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR004176; Clp_N.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF81923; SSF81923; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q8IB03.
DR   SWISS-2DPAGE; Q8IB03.
KW   3D-structure {ECO:0000213|PDB:2P65, ECO:0000213|PDB:4XBI};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          351..496
FT                   /note="AAA"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          808..979
FT                   /note="AAA"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          978..1067
FT                   /note="ClpB_D2-small"
FT                   /evidence="ECO:0000259|SMART:SM01086"
FT   REGION          602..625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          405..425
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          679..699
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          756..776
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1070 AA;  122508 MW;  8F94614898D21E0C CRC64;
     MVNSFFFCFV IIGLIYVWDI TYSKKAKIFF NKNDIFSIKN THWDIYDKKK YFFIGNNHLK
     NEESFLPEVR KDYKSQIKEY KNSTNGIIYH NNKNRLSYTI NDQVNYDNNM TSGINKKRKV
     KDSSIHMNNS YEKNRNKNKF ALFMSDEEYT INSDDYTEKA WEAISSLNKI GEKYDSAYVE
     AEMLLLALLN DSPDGLAERI LKESGIDTQL LVQEIDDYLK KQPKMPSGFG EQKILGRTLQ
     TVLSTSKRLK KEFNDEYISI EHLLLSIISE DSKFTRPWLL KYNVNYEKVK KAVEKIRGKK
     KVTSKTPEMT YQALEKYSRD LTALARAGKL DPVIGRDNEI RRAIQILSRR TKNNPILLGD
     PGVGKTAIVE GLAIKIVQGD VPDSLKGRKL VSLDMSSLIA GAKYRGDFEE RLKSILKEVQ
     DAEGQVVMFI DEIHTVVGAG AVAEGALDAG NILKPMLARG ELRCIGATTV SEYRQFIEKD
     KALERRFQQI LVEQPSVDET ISILRGLKER YEVHHGVRIL DSALVQAAVL SDRYISYRFL
     PDKAIDLIDE AASNLKIQLS SKPIQLENIE KQLIQLEMEK ISILGDKQKN LFNYSSVANT
     HNNNNNSSIS SNNSSSYGNA EETEATVDYT KSPNFLKKRI NEKEIDRLKM IDRIMSELRK
     EQRKILDSWS TEKSYVDNIR AIKERIDVVK IEIEKAERYF DLNRAAELRF ETLPDLEKQL
     KKAEENYLND IPEKSRILKD EVTSEDIVNI VSMSTGIRLN KLLKSEKEKI LNLENELHKQ
     IIGQDDAVKV VTKAVQRSRV GMNNPKRPIA SLMFLGPTGV GKTELSKVLA DVLFDTPEAV
     IHFDMSEYME KHSISKLIGA APGYVGYEQG GLLTDAVRKK PYSIILFDEI EKAHPDVYNL
     LLRVIDEGKL SDTKGNVANF RNTIIIFTSN LGSQSILDLA NDPNKKEKIK EQVMKSVRET
     FRPEFYNRID DHVIFDSLSK KELKEIANIE IRKVANRLFD KNFKITIDDA VFSYIVDKAY
     DPSFGARPLK RVIQSEIETE IAVRILDETF VENDTINISL KDQKLHFSKS
//

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