(data stored in SCRATCH zone)

SWISSPROT: Q8IAZ6_PLAF7

ID   Q8IAZ6_PLAF7            Unreviewed;       666 AA.
AC   Q8IAZ6;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 117.
DE   SubName: Full=Dihydrolipoyl dehydrogenase, apicoplast {ECO:0000313|EMBL:CAD51214.1};
DE            EC=1.8.1.4 {ECO:0000313|EMBL:CAD51214.1};
GN   ORFNames=PF3D7_0815900 {ECO:0000313|EMBL:CAD51214.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51214.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide
CC       oxidoreductase family. {ECO:0000256|RuleBase:RU003691}.
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DR   EMBL; AL844507; CAD51214.1; -; Genomic_DNA.
DR   RefSeq; XP_001349365.1; XM_001349329.1.
DR   EnsemblProtists; CAD51214; CAD51214; PF3D7_0815900.
DR   GeneDB; PF3D7_0815900.1:pep; -.
DR   GeneID; 2655265; -.
DR   KEGG; pfa:PF3D7_0815900; -.
DR   EuPathDB; PlasmoDB:PF3D7_0815900; -.
DR   HOGENOM; HOG000276708; -.
DR   InParanoid; Q8IAZ6; -.
DR   KO; K00382; -.
DR   OMA; RFEKQGI; -.
DR   PhylomeDB; Q8IAZ6; -.
DR   BioCyc; PLASMO:PF08_0066-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0020011; C:apicoplast; IDA:GeneDB.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048037; F:cofactor binding; IDA:GeneDB.
DR   GO; GO:0004148; F:dihydrolipoyl dehydrogenase activity; IDA:GeneDB.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:GeneDB.
DR   GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IMP:GeneDB.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.390.30; -; 1.
DR   Gene3D; 3.50.50.60; -; 2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR   InterPro; IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
DR   InterPro; IPR012999; Pyr_OxRdtase_I_AS.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   Pfam; PF02852; Pyr_redox_dim; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   SUPFAM; SSF55424; SSF55424; 1.
DR   PROSITE; PS00076; PYRIDINE_REDOX_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8IAZ6.
DR   SWISS-2DPAGE; Q8IAZ6.
KW   FAD {ECO:0000256|RuleBase:RU003691};
KW   Flavoprotein {ECO:0000256|RuleBase:RU003691};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003691,
KW   ECO:0000313|EMBL:CAD51214.1};
KW   Redox-active center {ECO:0000256|RuleBase:RU003691};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        9..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          126..493
FT                   /note="Pyr_redox_2"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
FT   DOMAIN          525..656
FT                   /note="Pyr_redox_dim"
FT                   /evidence="ECO:0000259|Pfam:PF02852"
SQ   SEQUENCE   666 AA;  75587 MW;  1A876D357BBE3AEB CRC64;
     MVIRQNIKHI VKLNVVTLIW LSYLFLLKPH GTLKNMMVCN AVLLPFNEKN KGINNFVYIN
     PKNIILNKIK KDVIKLEKDN IILCQHNRKR DNYIKQQKRK EKNANNFTFM LKGSTQNIMN
     INEKEYDLAI IGCGVGGHAA AINAMERNLK VIIFAGDENC IGGTCVNVGC IPSKALLYAT
     NKYRELKNLD KLYYYGIHSN IFQNNKNTEI ENNQLVSNSF QINITKLKEY TQSVIDKLRN
     GISHGFKTLK FNKNSEHVQV IYEHGQLLDK NTIKSKKSGN TYKVKNIIIA TGSVPNIPNN
     VEIDDKSVFT SDMAVKLVGL KNYMSIIGMG IIGLEFADIY TALGSEITFL EYSSELLPII
     DNDVAKYFER VFLKNKPVNY HLNTEVKYIK ASKNNNPVII GYSHRTGNDD NEKKNMTDVK
     ELYVDSCLVA TGRNPNTQNL GLEKLKIQMN RGYVSVNDNL QVKMENNEIY DNIFCIGDAN
     GKQMLAHTAS YQALKVIDFI EKKEKKNVNI NVENNLSKPI LYKNIPSVCY TNPELAFIGL
     TEKEAKVLYP DNVGVEISYY KSNSKILCEN NISLNNNKKN NSYNKGQYNI NDNTNGMVKI
     IYKEDTKEIL GMFIVGNYAS VLIHEAVLAI NLKLSAFDLA YMVHSHPTVS EVLDTAFKSI
     SKIRTH
//

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