(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAZ3_PLAF7

ID   Q8IAZ3_PLAF7            Unreviewed;       268 AA.
AC   Q8IAZ3;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   08-MAY-2019, entry version 109.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit G {ECO:0000256|HAMAP-Rule:MF_03006};
DE            Short=eIF3g {ECO:0000256|HAMAP-Rule:MF_03006};
DE   AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit {ECO:0000256|HAMAP-Rule:MF_03006};
DE            Short=eIF-3 RNA-binding subunit {ECO:0000256|HAMAP-Rule:MF_03006};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 4 {ECO:0000256|HAMAP-Rule:MF_03006};
GN   ORFNames=PF3D7_0815600 {ECO:0000313|EMBL:CAD51217.2};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51217.2, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with
CC       other initiation factors, stimulates binding of mRNA and
CC       methionyl-tRNAi to the 40S ribosome. The eIF-3 complex
CC       specifically targets and initiates translation of a subset of
CC       mRNAs involved in cell proliferation. This subunit can bind 18S
CC       rRNA. {ECO:0000256|HAMAP-Rule:MF_03006}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor
CC       3 (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03006}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit G family.
CC       {ECO:0000256|HAMAP-Rule:MF_03006}.
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DR   EMBL; AL844507; CAD51217.2; -; Genomic_DNA.
DR   SMR; Q8IAZ3; -.
DR   IntAct; Q8IAZ3; 1.
DR   PRIDE; Q8IAZ3; -.
DR   EnsemblProtists; CAD51217; CAD51217; PF3D7_0815600.
DR   GeneDB; PF3D7_0815600.1:pep; -.
DR   EuPathDB; PlasmoDB:PF3D7_0815600; -.
DR   HOGENOM; HOG000239560; -.
DR   InParanoid; Q8IAZ3; -.
DR   Reactome; R-PFA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-PFA-450520; HuR (ELAVL1) binds and stabilizes mRNA.
DR   Reactome; R-PFA-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-PFA-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-PFA-72702; Ribosomal scanning and start codon recognition.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:GeneDB.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006412; P:translation; ISS:GeneDB.
DR   CDD; cd12408; RRM_eIF3G_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   HAMAP; MF_03006; eIF3g; 1.
DR   InterPro; IPR017334; eIF3_g.
DR   InterPro; IPR034240; eIF3G_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8IAZ3.
DR   SWISS-2DPAGE; Q8IAZ3.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03006};
KW   Initiation factor {ECO:0000256|HAMAP-Rule:MF_03006,
KW   ECO:0000313|EMBL:CAD51217.2};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_03006};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT   DOMAIN      187    265       RRM. {ECO:0000259|PROSITE:PS50102}.
FT   COILED      135    155       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   268 AA;  31251 MW;  F094FC855AE5BB27 CRC64;
     MIQTEKKWAD IDVDDDESIN DNEIKKKWED IDADDDLEAN KKLSYFTNYE NGIKVVTKYS
     ENLKKQTVKV TKKIQEVVIK KKLNKEINNR LNLKNFNIDI HSSVTVEPTD VVNIEVPKNN
     PLDFLKDTEY DYLFAEQTNK TAKDLKNRFK ILKDEETEDV KAEDPSKAAG RREGLYYRPH
     DTQNKECTVR VTNLSEDVNE NELSNLFGKV GNIVRMFLAK HKETQNSKGF AFITYSKREE
     AKRAIEKLNR HGFENLLLSV EWAKPSNR
//

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