(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAZ0_PLAF7

ID   Q8IAZ0_PLAF7            Unreviewed;      1182 AA.
AC   Q8IAZ0;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 92.
DE   SubName: Full=FAD-dependent monooxygenase, putative {ECO:0000313|EMBL:CAD51220.1};
DE            EC=1.14.13.8 {ECO:0000313|EMBL:CAD51220.1};
GN   ORFNames=PF3D7_0815300 {ECO:0000313|EMBL:CAD51220.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51220.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51220.1; -; Genomic_DNA.
DR   RefSeq; XP_001349371.1; XM_001349335.1.
DR   SMR; Q8IAZ0; -.
DR   IntAct; Q8IAZ0; 1.
DR   EnsemblProtists; CAD51220; CAD51220; PF3D7_0815300.
DR   GeneDB; PF3D7_0815300.1:pep; -.
DR   GeneID; 2655267; -.
DR   KEGG; pfa:PF3D7_0815300; -.
DR   EuPathDB; PlasmoDB:PF3D7_0815300; -.
DR   HOGENOM; HOG000280929; -.
DR   InParanoid; Q8IAZ0; -.
DR   OMA; KWTMHSS; -.
DR   PhylomeDB; Q8IAZ0; -.
DR   BioCyc; PLASMO:PF08_0068-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.50.50.60; -; 2.
DR   InterPro; IPR002938; FAD-bd.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01494; FAD_binding_3; 2.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   4: Predicted;
DR   PRODOM; Q8IAZ0.
DR   SWISS-2DPAGE; Q8IAZ0.
KW   Monooxygenase {ECO:0000313|EMBL:CAD51220.1};
KW   Oxidoreductase {ECO:0000313|EMBL:CAD51220.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          6..131
FT                   /note="FAD_binding_3"
FT                   /evidence="ECO:0000259|Pfam:PF01494"
FT   DOMAIN          350..543
FT                   /note="FAD_binding_3"
FT                   /evidence="ECO:0000259|Pfam:PF01494"
FT   REGION          1088..1117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1099..1117
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1182 AA;  140226 MW;  FCA8E1EB290369FD CRC64;
     MKVRKTFVLI IGGGPTGITS GLYLQKYNIP HILIEKDKSI EKIPKAHYYN NQTMEAWRCL
     YHLDKCFMNE TEKLDLWKNF QYSLSMHKEK IISIYNNFIN KYTYKNTYYE DISPSKVTHL
     SQYKLLGILY NYYFFNIKVN KKKREFLKNI KLKFSTYKIL KCIYENSVIN NEVNDKHIHN
     VHDKHIHNVH DKHIHNVHDK HIYNSHDKHI YNVHDKHIYN VHDKHIYNVH DKHIYNVHDK
     HIYNSHDKKK EDLINDKFLK CCSYDISQML IGYEFVDFIK NINDLKNIDN LSLSQEEKII
     LEKMCMDNMS HDNKYRVPMN SNVDPCDVSK DMKENYKYED NNYNSTNNCF ENSANYVLTK
     IRNVETNLEE IVLSNYVFVC EGGKSNIKNF LNINDENIKN YMKFINIHFS SKYLSTLMIY
     NPSMLYFLFN EYIGILVCHD YKKGNVVLHI PYLTKREMLL YSNPNKIKEI INKLIGFNLY
     DIHIYNIYKW TMYSSIASTF IDNYTKRIFL LGDSAHKLPP SGGFGLNLGI GDVLNISWKI
     IRIFNLHQKK INQFVFNKTI KNKSTDLNDY LCNDTRLSNS FLNLIKKEIK IQDFIMNTLF
     TEKEKNMIYN YIHSYNIERK LVANFTISQA VNNYEKGKNI PYILGYNQDN ILIDKLSKMC
     NFKSTNCHNN NNNNNNNNNN KNNNNNNKSC GTYIYNYNNY GSHTFGGYNK LHVRILQNSL
     IFHTLLQGSK KIINMLNQIP FIFSYKKKKI KNLVNTRENV LGLLYPGADF CYSYINTLNN
     LEEYINHHKI IKNNTSNYNH IYNPNMLHIN NNSNNNNYDK DEQMENQNDH NEIKILPKKY
     DNINTINNVY EKNNLEHKYE NHIHINEMHN DKKFSSEYIN NNNKKYNFAK SMTTCSSYNF
     QNNYDKEENK LYDTNKKQDK NKIFSSNNNM ESIPKLKVCK NIYEYEIPNI IGSKIPHFNL
     YTLDKNYVYK LSSVDLPILN NPSLSILIIL FDELLLYETI NFLLLNNIPN DKFSLCLWDS
     DVFLYKDKTS GNMKLIKEEM YNNIDNKNIS MDHVQINDYV LFKKENGEQE PIGDISYVKH
     INGITNKNIN DNKKNNKKKN NNNNNNNNSY NNNYNNSYNY SHRGKRSINY VFTSRIIKEM
     FLNIVGVKSN NAYVILRPDK HIISVSVNNL FDEIKKINNI YI
//

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