(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAX6_PLAF7

ID   Q8IAX6_PLAF7            Unreviewed;       215 AA.
AC   Q8IAX6;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 114.
DE   RecName: Full=60S ribosomal protein L13 {ECO:0000256|RuleBase:RU000572};
GN   ORFNames=PF3D7_0814000 {ECO:0000313|EMBL:CAD51234.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51234.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000213|PDB:3J79}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS).
RX   PubMed=24913268; DOI=10.7554/eLife.03080;
RA   Wong W., Bai X.C., Brown A., Fernandez I.S., Hanssen E., Condron M.,
RA   Tan Y.H., Baum J., Scheres S.H.;
RT   "Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the
RT   anti-protozoan drug emetine.";
RL   Elife 3:e03080-e03080(2014).
RN   [4] {ECO:0000213|PDB:3JBN, ECO:0000213|PDB:3JBO, ECO:0000213|PDB:3JBP}
RP   STRUCTURE BY ELECTRON MICROSCOPY (4.70 ANGSTROMS) OF 2-212.
RX   PubMed=26432834; DOI=10.1093/nar/gkv991;
RA   Sun M., Li W., Blomqvist K., Das S., Hashem Y., Dvorin J.D., Frank J.;
RT   "Dynamical features of the Plasmodium falciparum ribosome during
RT   translation.";
RL   Nucleic Acids Res. 43:10515-10524(2015).
RN   [5] {ECO:0000213|PDB:5UMD}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS).
RX   PubMed=28288098; DOI=10.1038/nmicrobiol.2017.31;
RA   Wong W., Bai X.C., Sleebs B.E., Triglia T., Brown A., Thompson J.K.,
RA   Jackson K.E., Hanssen E., Marapana D.S., Fernandez I.S., Ralph S.A.,
RA   Cowman A.F., Scheres S.H., Baum J.;
RT   "Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit
RT   protein synthesis.";
RL   Nat. Microbiol. 2:17031-17031(2017).
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL13 family.
CC       {ECO:0000256|RuleBase:RU000572}.
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DR   EMBL; AL844507; CAD51234.1; -; Genomic_DNA.
DR   RefSeq; XP_001349385.1; XM_001349349.1.
DR   PDB; 3J79; EM; 3.20 A; L=1-215.
DR   PDB; 3JBN; EM; 4.70 A; AL=2-212.
DR   PDB; 3JBO; EM; 5.80 A; AL=2-212.
DR   PDB; 3JBP; EM; 6.70 A; AL=2-212.
DR   PDB; 5UMD; EM; 3.20 A; L=1-215.
DR   PDBsum; 3J79; -.
DR   PDBsum; 3JBN; -.
DR   PDBsum; 3JBO; -.
DR   PDBsum; 3JBP; -.
DR   PDBsum; 5UMD; -.
DR   SMR; Q8IAX6; -.
DR   IntAct; Q8IAX6; 1.
DR   PRIDE; Q8IAX6; -.
DR   EnsemblProtists; CAD51234; CAD51234; PF3D7_0814000.
DR   GeneDB; PF3D7_0814000.1:pep; -.
DR   GeneID; 2655274; -.
DR   KEGG; pfa:PF3D7_0814000; -.
DR   EuPathDB; PlasmoDB:PF3D7_0814000; -.
DR   HOGENOM; HOG000170452; -.
DR   InParanoid; Q8IAX6; -.
DR   KO; K02873; -.
DR   OMA; FRKDWQS; -.
DR   PhylomeDB; Q8IAX6; -.
DR   Reactome; R-PFA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-PFA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-PFA-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-PFA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-PFA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-PFA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; ISS:GeneDB.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISS:GeneDB.
DR   GO; GO:0006412; P:translation; ISS:GeneDB.
DR   HAMAP; MF_00499; Ribosomal_L13e; 1.
DR   InterPro; IPR001380; Ribosomal_L13e.
DR   InterPro; IPR018256; Ribosomal_L13e_CS.
DR   PANTHER; PTHR11722; PTHR11722; 1.
DR   Pfam; PF01294; Ribosomal_L13e; 1.
DR   PROSITE; PS01104; RIBOSOMAL_L13E; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q8IAX6.
DR   SWISS-2DPAGE; Q8IAX6.
KW   3D-structure {ECO:0000213|PDB:3J79, ECO:0000213|PDB:3JBN,
KW   ECO:0000213|PDB:3JBO, ECO:0000213|PDB:3JBP};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Ribonucleoprotein {ECO:0000256|RuleBase:RU000572};
KW   Ribosomal protein {ECO:0000256|RuleBase:RU000572,
KW   ECO:0000313|EMBL:CAD51234.1}.
FT   REGION          195..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   215 AA;  25441 MW;  6B4F20FDE9CC58B7 CRC64;
     MVAHNNVLPN VHLHKWWQRH VRVNFSKNIK KKKRRLLREK RRKANGGTPI EKLHPIVHCP
     TQRYNFRTRL GKGFTFEELK GAGLTPRAAQ TIGICYDKRR KNRSEESLTK NVERLLKYKN
     SLVMIPLKKN KAKKGIGGIP ADADKNTIKE FRNKKPLLSI FKKEKNTKPF YETIEVSKID
     KEFLAYKTLR RAKLAERRKN RRQQKKDIKF KSKDN
//

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