(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAX4_PLAF7

ID   Q8IAX4_PLAF7            Unreviewed;       357 AA.
AC   Q8IAX4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 97.
DE   SubName: Full=GDP-mannose 4,6-dehydratase {ECO:0000313|EMBL:CAD51236.1};
DE            EC=4.2.1.47 {ECO:0000313|EMBL:CAD51236.1};
GN   ORFNames=PF3D7_0813800 {ECO:0000313|EMBL:CAD51236.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51236.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51236.1; -; Genomic_DNA.
DR   RefSeq; XP_001349387.1; XM_001349351.1.
DR   SMR; Q8IAX4; -.
DR   EnsemblProtists; CAD51236; CAD51236; PF3D7_0813800.
DR   GeneDB; PF3D7_0813800.1:pep; -.
DR   GeneID; 2655276; -.
DR   KEGG; pfa:PF3D7_0813800; -.
DR   EuPathDB; PlasmoDB:PF3D7_0813800; -.
DR   HOGENOM; HOG000168003; -.
DR   InParanoid; Q8IAX4; -.
DR   KO; K01711; -.
DR   OMA; TDCLYLG; -.
DR   PhylomeDB; Q8IAX4; -.
DR   BioCyc; PLASMO:PF08_0077-MONOMER; -.
DR   Reactome; R-PFA-6787639; GDP-fucose biosynthesis.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR   GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IDA:GeneDB.
DR   GO; GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006004; P:fucose metabolic process; IDA:GeneDB.
DR   GO; GO:0019673; P:GDP-mannose metabolic process; IDA:GeneDB.
DR   HAMAP; MF_00955; GDP_Man_dehydratase; 1.
DR   InterPro; IPR006368; GDP_Man_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01472; gmd; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8IAX4.
DR   SWISS-2DPAGE; Q8IAX4.
KW   Lyase {ECO:0000313|EMBL:CAD51236.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          5..326
FT                   /note="NAD(P)-bd_dom"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
SQ   SEQUENCE   357 AA;  41540 MW;  CAE16AA607E022E0 CRC64;
     MRVALIFGIT GQDGSYLSEL LLEKNYHVHG VIRRCSSFNT KRIDHIFDKL ILHYGDLLDS
     SNICSLICEI KPNEIYNLAA QSHVKVSFEM PEYTTEATAL GTLRILEGIR ISKVKNIKFY
     NASTSELFGK VQCPIQNENT PFYPVSPYAI AKLYAHYITI NYRESYNMFC INGILFNHES
     PRRGETFVTR KITRGIAKIQ KKLETSIILG NIDTYRDWGH AKDYVYAMYL MLQQNEADDF
     VICSNEQHSV REFCEISFSF VNIHIKWIGK GIQEIGVDQN NNVLIKKHEK YFRNCEVNTL
     LGDCSKAKNI LKWEPTYTFT QLVYEMLKCD MQDYNLSMDD YDTCMKKYDT YKMGKKQ
//

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