(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAV6_PLAF7

ID   Q8IAV6_PLAF7            Unreviewed;      2651 AA.
AC   Q8IAV6;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 85.
DE   SubName: Full=Proteasome activator complex subunit 4, putative {ECO:0000313|EMBL:CAD51254.1};
GN   ORFNames=PF3D7_0812100 {ECO:0000313|EMBL:CAD51254.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51254.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51254.1; -; Genomic_DNA.
DR   RefSeq; XP_001349405.1; XM_001349369.1.
DR   IntAct; Q8IAV6; 1.
DR   SwissPalm; Q8IAV6; -.
DR   PRIDE; Q8IAV6; -.
DR   EnsemblProtists; CAD51254; CAD51254; PF3D7_0812100.
DR   GeneDB; PF3D7_0812100.1:pep; -.
DR   GeneID; 2655288; -.
DR   KEGG; pfa:PF3D7_0812100; -.
DR   EuPathDB; PlasmoDB:PF3D7_0812100; -.
DR   HOGENOM; HOG000280956; -.
DR   InParanoid; Q8IAV6; -.
DR   OMA; YPDERYN; -.
DR   BioCyc; PLASMO:PF08_0089-MONOMER; -.
DR   Reactome; R-PFA-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR   Reactome; R-PFA-382556; ABC-family proteins mediated transport.
DR   Reactome; R-PFA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR   Reactome; R-PFA-5687128; MAPK6/MAPK4 signaling.
DR   Reactome; R-PFA-5689603; UCH proteinases.
DR   Reactome; R-PFA-5689880; Ub-specific processing proteases.
DR   Reactome; R-PFA-68949; Orc1 removal from chromatin.
DR   Reactome; R-PFA-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   Reactome; R-PFA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0070577; F:lysine-acetylated histone binding; IBA:GO_Central.
DR   GO; GO:0016504; F:peptidase activator activity; IBA:GO_Central.
DR   GO; GO:0070628; F:proteasome binding; IBA:GO_Central.
DR   GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035309; PSME4.
DR   InterPro; IPR021843; PSME4_C.
DR   PANTHER; PTHR32170; PTHR32170; 1.
DR   Pfam; PF11919; DUF3437; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   4: Predicted;
DR   PRODOM; Q8IAV6.
DR   SWISS-2DPAGE; Q8IAV6.
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Proteasome {ECO:0000313|EMBL:CAD51254.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        2189..2211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2564..2650
FT                   /note="DUF3437"
FT                   /evidence="ECO:0000259|Pfam:PF11919"
FT   REGION          604..661
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1260..1333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2085..2111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          401..421
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1071..1091
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2651 AA;  314494 MW;  70119776C82E2EE5 CRC64;
     MLDVFRELNN YTNFLPKNIK ANVNKEKYEI LSEIKRIVFL KKRNSYNVAS VIKLFNTYEV
     INTKKYKSFH FYIFMIRYLW NSLQNKSISP NLKCYICQCI SSIFKNIKKY ILYDFFFEYD
     RKLILKEENG KNENVAKCVE SHFDKGMKSD CTNNSYAYMS DNYYDEYQNL HEGSELDSSI
     NDNKLNIFND VYVTCNGIYE KNKKKEDETF LNEEVIINGK DESFRLYIQK CIFNIIDYKY
     LFNLLYEYLS NNNNNYINNN NNNNNNNKHD EYSHNAYKSY MGAILNLLNH IKYFCYYNID
     VHNLLVEFAL NNDYSYLYEE YVDSNDKEGL FSEEDYFDKN NVIFLINRKL NERKNIHNNN
     DDYNTNCDEE YIKADNIINI NKDGQNDSCD MLEKNTNVKN IDNITNEYDN TLMEKRHVQN
     NYLNIDKSVC DIKDLEVCTR YNTIFLNYVL LSQLSSHDLC YKLIKYKKVL YLYKKIRRFN
     WNCINYAFVN IIYKGLKYAY IYNLNIENEM QEILHVIYFL FLFYIKLPSN VQLNSSKYFI
     PEDYNLLVND NESVVKVISK IFVFLLNKKY KKGNHNPSNK NENDPQELLY KFLSTMNEKN
     FTMTEMNTNN SNTNFMYNNT NGNNNNDNKN DNNNDNNNDN NNDNNNDNNN DNNNDNNNDN
     SCDNSLRENF FPIFTNIDTY EYLNIITSLF MPHIHPSNIG KHIGNINLFI NSFLYCFIRK
     MKREEIYLKR KNKKTEFCKK MENNKINGTS HLDNTNTNNE YLEQKYMNDY VNNFFIMEDD
     KKFVIEKFMA LAVQGMFPKS NKGISLFENI LKHLCIIDIN CLDIFVKKIM DCLMNVNIST
     QICNCLLSLC LLLPLLIKYK SKYLKDILYV MNMGIDICDV YKSFTIFSFL SILFSYISIV
     KLDTCTNDDY TLAIDEYKKM ISLFSEDNKK MLNKEDIKKL LIERKELIDY MCYWVYEFFD
     KILYFIKFSK SQKSKDSKKQ NGDNKDNKIE NDLYTGLKTT IISLFIHLDH KIVYDLSQRF
     LNNIELENSK FLSIIPYAIS LVDNKKIFDL LFNAFYKKLI IKKKKKRIII LSSANNNMNN
     MNNETSKCQQ TSLESQQIEE YYVYTKNEYA NDDTVKCYLQ FLSSLMRRAK NEFLNVEDIY
     QLIKIYIVED NISVFKYICK IIYRFLEYNF SVTIMDYSCF PINEKMSNKE KLCTAAYWGI
     PWHVIVYYEN IMNHTNVSPN RINHTNVLSN RINHTNVLSN QINDTNVSPN RINHTNVLSN
     QINDTNVTPN QINDTSVSPH KSNDTNVSPN QINDTNVSPN QINDTTVSPH KSSDTNVSPN
     QINDTTVSPH KSNDTNELIK WKTPLLEDVK VGKKFIFFLL DYLIDLLIQC DIPINTPNIL
     RYIEKRKLDE NRRKIEWKFS LTYANVISRI YKVIKCIIKP TSFLYPDERY NYNNLLTKCH
     VINSKLSFVL YVYISEIVIT LSLHVLKVPA NILDMSTFIR ACNDNEEKTE NSSNEKIVQN
     MDNKSELKKL KEEFYNIVIK NREKDIKADA KVQRKMIKNI HFLLLKCNEN ANSSLYNEYI
     NSVLSFTYNI YPYSYNYDII KSQYINNIFY LFNERLKQRK KNYAFRGFRK QLCNILFYIN
     LSIYSQVRSY AQNTIKLILP SFKMIKVSFL KTCAFYLKNY IKLYLLSKGD ILRKKKTLDD
     SNDGELKEQN MKRDVINKEN ISIEKNDEEE SAIQNTSEHI NNTEFVKESN ISNEYDNNIN
     NASINKWSSL KSLNDLNNND YFENKCISSF NGIIVSILNN MGLIKKISTD VYLLKKFLKV
     IIRILRLDIQ KEDITMKCMK LVYSIINNRF IKKSVEEKRK KKKINKLFLC LKEESEKKNN
     VYSQIVIMSF LICFNYFVVE NHCEFYFNYL VENLSIKKNV HVYNLAFCGF IKMLKYLNDF
     HLKGVMPKHI ALTFETDKIY KNFIDICIYK NLKNKKKNNS MNAIIINLSK IQKPFKGFTQ
     ISETYLKDFY SYYVFFEFLV NIQNTYFEEM QEKEARLHTM ENLMRDENYN KDITEEQTIK
     ENVDAHIVEC ISTHNGNDNG EYISDHLNKH NLEEKEGNHI SCNENMISDK ANDSGDNNNN
     NNNNNEKEPR NDITYSENLN VKNCKLKYFE MVLIILKELQ MDIHYSDNEY KCAFISILCP
     LLLSIRKLRN KEESEDIIKV IVNLLEKEIA IVNIEVFNVW IYCFHLLFIN IKKKYIHVYN
     KLFDFCLRFN VQDISNVTFK KKMQLLDIML LYSLHKNVYM LDNSLMTLVK LIENDNISVR
     QIIGDVFCYM LYVLYDNKHY EHLKCMYYNI LLFLYTSANN VITYLEENSI SLSKQSKYIY
     ILETCAYLTL TAFNNKCMYV FNNLSIIFLK MFMLSFQLVD VFINGLVSKA INCFLCPSLY
     LFKFDIINSS NNNIQIYDIN NNNDNNLKNV GFPEQVHNLN ILLEEDIGTL VIKNISNLIN
     KSNWKIRNCA LQFCYYFHLY YCIFFYNKKE NAFLLNMFIS LLVDSYIEIQ NLSRDILSSV
     FCYYDNKTLQ IFSSYFLSIL NDHKNLQKLP SISKKTSFKI IDKKKTVSIY ALISIVNSFP
     NYIPPWLPNI LISVAKLSNS SSHVIKKEIE KCIQNFLRTH KDEWEYKYKQ IFTEEQLNIL
     DLYKGELNYF T
//

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