(data stored in SCRATCH zone)

SWISSPROT: Q8IAU5_PLAF7

ID   Q8IAU5_PLAF7            Unreviewed;       829 AA.
AC   Q8IAU5;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 2.
DT   11-DEC-2019, entry version 105.
DE   SubName: Full=Cullin-1, putative {ECO:0000313|EMBL:CAD51265.2};
GN   ORFNames=PF3D7_0811000 {ECO:0000313|EMBL:CAD51265.2};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51265.2, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00330, ECO:0000256|RuleBase:RU003829,
CC       ECO:0000256|SAAS:SAAS00585788}.
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DR   EMBL; AL844507; CAD51265.2; -; Genomic_DNA.
DR   RefSeq; XP_001349416.2; XM_001349380.2.
DR   PRIDE; Q8IAU5; -.
DR   EnsemblProtists; CAD51265; CAD51265; PF3D7_0811000.
DR   GeneDB; PF3D7_0811000.1:pep; -.
DR   GeneID; 2655293; -.
DR   KEGG; pfa:PF3D7_0811000; -.
DR   EuPathDB; PlasmoDB:PF3D7_0811000; -.
DR   HOGENOM; HOG000280965; -.
DR   InParanoid; Q8IAU5; -.
DR   KO; K03347; -.
DR   OMA; WLWHLCK; -.
DR   PhylomeDB; Q8IAU5; -.
DR   Reactome; R-PFA-110314; Recognition of DNA damage by PCNA-containing replication complex.
DR   Reactome; R-PFA-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-PFA-5696395; Formation of Incision Complex in GG-NER.
DR   Reactome; R-PFA-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-PFA-6782135; Dual incision in TC-NER.
DR   Reactome; R-PFA-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-PFA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
DR   SUPFAM; SSF75632; SSF75632; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8IAU5.
DR   SWISS-2DPAGE; Q8IAU5.
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          440..709
FT                   /note="CULLIN_2"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   829 AA;  100272 MW;  4E63799B4FA991AA CRC64;
     MDIVNINFES GWKIIREEAI EKIEKYLENE HIEKNKNLFS ATEYTRLYTV VYNMCAKKNP
     FCYSKEVYRK YGESLSMYTI DKIKPLLKNS DELNKTKILI DAWFKYSFYT KWMNKFLRYL
     DRYYVEYNSS LCLSAYTKNI FKITLFNELR EDIKNIIYEI YNNLRLQEEI DQKELFCNIV
     ELYKELDNES NEKMYEHDIE KKIVENVNNF YKKKAEEWIN DYPFDDYIIS IENAIEKEYE
     KNKSLNLNDD TCEKVTNIIV KILIYEKLNT LIDNKNNIFH LLKNNNLSSL RRTYILFSYF
     PEALTGLKKI IGEYIKMEGN ELKDKYVQLS RKMHMSKNVN NMQNVDDNTM EDNDNYIDIS
     NDDNNNNDNS NNNNIMNTEQ NDDIILCDYI EQLIKLHNHY DNIFKLSFFN ISNKNIDPNF
     NECLKDYFES FVEHEDEYFS TVKLLVIYTD NILKRDLNNE NSVDEKQKIH MNKEEKNDEQ
     TKFLMKKMSE IVEIFNYTSN KETFFEYYRV YLANRLINNI YISLHIEKKF IEQLYYLCGS
     QYTSKLGGMI QDLINNTNMN NKFYDHMKNV FNNNEIVNNN NNNSIYNDHF SNYHNVKDFF
     SVKILNKGYW PTLEKIHIQL NEPFNKYIQV FEEYYKSENK NRKLEWIYEL SEVILHYEFN
     NILYNLYCNV VNAQILLLFN KYKYINYDIV KNELQIDLKS FTDHMYTSFY HFKLITSNDQ
     IPDWTNSNFY INNNFSYPNK NVYIKKTTAL LSKEHEKTKE DRTMAIEAAI VRVMKMHKKL
     FYDQIFDYVK KSLSSFSPTN QVIEKKIDLL VEREYIQKEE NSQIYVYIP
//

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