(data stored in SCRATCH zone)

SWISSPROT: Q8IAU3_PLAF7

ID   Q8IAU3_PLAF7            Unreviewed;       706 AA.
AC   Q8IAU3;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 98.
DE   SubName: Full=Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase {ECO:0000313|EMBL:CAD51267.1};
DE            EC=2.5.1.15 {ECO:0000313|EMBL:CAD51267.1};
DE            EC=2.7.6.3 {ECO:0000313|EMBL:CAD51267.1};
GN   ORFNames=PF3D7_0810800 {ECO:0000313|EMBL:CAD51267.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51267.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51267.1; -; Genomic_DNA.
DR   RefSeq; XP_001349418.1; XM_001349382.1.
DR   SMR; Q8IAU3; -.
DR   SwissPalm; Q8IAU3; -.
DR   PRIDE; Q8IAU3; -.
DR   EnsemblProtists; CAD51267; CAD51267; PF3D7_0810800.
DR   GeneDB; PF3D7_0810800.1:pep; -.
DR   GeneID; 2655294; -.
DR   KEGG; pfa:PF3D7_0810800; -.
DR   EuPathDB; PlasmoDB:PF3D7_0810800; -.
DR   HOGENOM; HOG000280968; -.
DR   InParanoid; Q8IAU3; -.
DR   KO; K00796; -.
DR   KO; K00950; -.
DR   OMA; NDISACT; -.
DR   PhylomeDB; Q8IAU3; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005740; C:mitochondrial envelope; IBA:GO_Central.
DR   GO; GO:0003848; F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004156; F:dihydropteroate synthase activity; IBA:GO_Central.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006761; P:dihydrofolate biosynthetic process; ISS:GeneDB.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.30.70.560; -; 1.
DR   InterPro; IPR006390; DHP_synth.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR000550; Hppk.
DR   InterPro; IPR035907; Hppk_sf.
DR   InterPro; IPR000489; Pterin-binding_dom.
DR   Pfam; PF01288; HPPK; 1.
DR   Pfam; PF00809; Pterin_bind; 1.
DR   SUPFAM; SSF51717; SSF51717; 1.
DR   SUPFAM; SSF55083; SSF55083; 1.
DR   TIGRFAMs; TIGR01496; DHPS; 1.
DR   PROSITE; PS00793; DHPS_2; 1.
DR   PROSITE; PS50972; PTERIN_BINDING; 1.
PE   4: Predicted;
DR   PRODOM; Q8IAU3.
DR   SWISS-2DPAGE; Q8IAU3.
KW   Kinase {ECO:0000313|EMBL:CAD51267.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transferase {ECO:0000313|EMBL:CAD51267.1}.
FT   DOMAIN          389..698
FT                   /note="Pterin-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50972"
SQ   SEQUENCE   706 AA;  83374 MW;  5B00E8BCA97691FC CRC64;
     METIQELILS EENKTNIAVL NLGTNDRRNA VLILETALHL VEKYLGKIIN TSYLYETVPE
     YIVLDKKESC EKINKDCRIY DVNYINELMQ NLEESKYEEN KELIDKCEEY ETFLKNGKVD
     NSILKEVNVE NYLLECNNII VKNDEIMKNN LSKYKDKYYT SYFYNLTVVV KTFVNDPLSM
     LVVIKYIEEL MKRENVKEKE KFENRIIDID ILFFNDFTIF MKNIKLEKNM IYKILSKYIH
     LERDIKNGND NMSKVNMDKD INLNNNNNIK KKNNNDIDCD CVDQKMNNHV NNKNYINSFR
     DPQEIINNMV DNIEFLSIPH VYTTHRYSIL LCLNDMIPEY KHNVLNNTIR CLYNKYVSRM
     KEQYNINIKE NNKRIYVLKD RISYLKEKTN IVGILNVNYD SFSDGGIFVE PKRAVQRMFE
     MINEGASVID IGGESSGPFV IPNPKISERD LVVPVLQLFQ KEWNDIKNKI VKCDAKPIIS
     IDTINYNVFK ECVDNDLVDI LNDISACTNN PEIIKLLKKK NKFYSVVLMH KRGNPHTMDK
     LTNYDNLVYD IKNYLEQRLN FLVLNGIPRY RILFDIGLGF AKKHDQSIKL LQNIHVYDEY
     PLFIGYSRKR FIAHCMNDQN VVINTQQKLH DEQQNENKNI VDKSHNWMFQ MNYMRKDKDQ
     LLYQKNICGG LAIASYSYYK KVDLIRVHDV LETKSVLDVL TKIDQV
//

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