(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAS7_PLAF7

ID   Q8IAS7_PLAF7            Unreviewed;      2109 AA.
AC   Q8IAS7;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 86.
DE   SubName: Full=Erythrocyte membrane protein 1, PfEMP1 {ECO:0000313|EMBL:CAD51283.1};
GN   ORFNames=PF3D7_0809100 {ECO:0000313|EMBL:CAD51283.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51283.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51283.1; -; Genomic_DNA.
DR   RefSeq; XP_001349434.1; XM_001349398.1.
DR   IntAct; Q8IAS7; 1.
DR   EnsemblProtists; CAD51283; CAD51283; PF3D7_0809100.
DR   GeneDB; PF3D7_0809100.1:pep; -.
DR   GeneID; 2655303; -.
DR   KEGG; pfa:PF3D7_0809100; -.
DR   EuPathDB; PlasmoDB:PF3D7_0809100; -.
DR   HOGENOM; HOG000115239; -.
DR   KO; K13850; -.
DR   OMA; MQERESK; -.
DR   PhylomeDB; Q8IAS7; -.
DR   Reactome; R-PFA-114608; Platelet degranulation.
DR   Reactome; R-PFA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0020002; C:host cell plasma membrane; TAS:GeneDB.
DR   GO; GO:0020030; C:infected host cell surface knob; TAS:GeneDB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0050839; F:cell adhesion molecule binding; TAS:GeneDB.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0020033; P:antigenic variation; TAS:GeneDB.
DR   GO; GO:0098609; P:cell-cell adhesion; TAS:GeneDB.
DR   GO; GO:0020035; P:cytoadherence to microvasculature, mediated by symbiont protein; TAS:GeneDB.
DR   GO; GO:0020013; P:modulation by symbiont of host erythrocyte aggregation; TAS:GeneDB.
DR   GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR   InterPro; IPR041480; CIDR1_gamma.
DR   InterPro; IPR004258; DBL.
DR   InterPro; IPR008602; Duffy-antigen_binding.
DR   InterPro; IPR029211; PfEMP1_ATS.
DR   InterPro; IPR029210; PfEMP1_NTS.
DR   Pfam; PF15445; ATS; 1.
DR   Pfam; PF18562; CIDR1_gamma; 1.
DR   Pfam; PF05424; Duffy_binding; 2.
DR   Pfam; PF15447; NTS; 1.
DR   Pfam; PF03011; PFEMP; 2.
PE   4: Predicted;
DR   PRODOM; Q8IAS7.
DR   SWISS-2DPAGE; Q8IAS7.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN       11     47       NTS. {ECO:0000259|Pfam:PF15447}.
FT   DOMAIN      592    737       PFEMP. {ECO:0000259|Pfam:PF03011}.
FT   DOMAIN     1346   1397       CIDR1_gamma. {ECO:0000259|Pfam:PF18562}.
FT   DOMAIN     1412   1557       PFEMP. {ECO:0000259|Pfam:PF03011}.
FT   DOMAIN     1674   2109       ATS. {ECO:0000259|Pfam:PF15445}.
FT   COILED      380    400       {ECO:0000256|SAM:Coils}.
FT   COILED     2079   2099       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2109 AA;  241113 MW;  11A41BA7CB65DBBD CRC64;
     MSTLGGGTDK SAKHVLDEFG QQVYEQVKNG EAKTYFDELH GDLSEATYPG DENPNKTTPP
     NPCLLQYDYN SNVTIGGGRE YPCKDRPEVR FSDEYGGQCT DSKIKGNEDN KGGACAPFRR
     LFLCDQHLSH MKAEKINNKH NLLLEVCLAA KYEGESLKGY HDKYNATYSD SRSQLCTVLA
     RSFADIGDII RGKDLFIGYD KKDRVQKKKL QDSLKNIFGN IYNELTTSGK NVDKAKARYN
     DPKGDFFQLR EDWWALNREK VWSAITCNAQ GNKYFRPTCS GGESIAHNKC TCINGDPPTY
     FDYVPQYLRW FEEWAEDFCR KRKHKLQNAK EQCRGKNGED KYCDLNGYDC KRTISAEKKL
     FPDSDCNKCS YSCIPFRTWI DNQKLEFLKQ KNKYDKEKEK NNDTTKTTRY GPINNLYAKD
     FYDKLKQQYI TVDSFLELLN KEKECKNHPE VGDGKKTFVD FSNKNVDETF SRTEICEPCP
     WCGIEKQEDG KWKRLNENAP ECPQEIEKTY PESNTTDIPV LTPEKGKTSI LQKYRIFCQN
     AENNKQIKEW QCHYEKNDKS DDSDETHNSD NCILGKWENF EKGQEFKSYY SFFYGSIIDM
     LKDSVDWRDK LNNCINNETK ACKNGCNKNC DCYKRWVEKK QQEWSNIKKH FGKQGDLLEE
     IKGEDPGKIL EFYLKSIFLQ DMKEAQGDPK AIKRFTDLLQ KKNNPGTDDT TKTIIDKFLQ
     EELTDANRCK ETHKDDCSQQ EVTRLRSADP SPDTVDSASE DEDEEDKDHQ EETEDTAQDT
     GQGEEETATE KVAPTVVDVC ATVAEALTKG DLNAACTLKY GTPNRYWGWK CIGDKTATGE
     ARAGRVARSP PETAPSSAKS GEPTGSICIP PRRRRLYIQK LHEWASRGGD EATKSQSQAG
     GSEAQPQGGE KSPSGKVSSQ SDKLRTAFIQ SAAIETFFLW HKYKAENTKT QSVGSPLLLL
     PQLPRSGSDD KDPETSLKSG TIPIDFLRLM FYTIADYKDI FEGKNMEVVN LLKDGSPSDK
     EMQERESKIK DAIDKVFPNS DNKKHSGVPS QTGNTTPQTL WSKYAEPIWN GMICALTYRD
     SEEKGGTPTQ NNTVKTELYD KNTKENGKYN YHTVTLEDDS DETRPKIGTS PSGEKTYLSK
     FVLRPPYFRY LEEWGETFCR ERTRRLEKIQ GDCTQGDDEY KCSGYGENCK DIREQDYSII
     SNFNCPDCGK SCRSYKKWIN IKKDEFTKHS NVYNEQKEKA KNNKDPESKS GNISDHEFVG
     KLDKDYASID SFLEKLGSCS KNNKDNGDGT INFKEPDVTF KPADNCKPCS EFKVNCRNGN
     CKGANGNTCN GETVTAEEIT KMSDSTVIDI RVSDNSENVF EDILDECQNA GIFEGIRKEQ
     WTCGYVCGVD ICEQTNVNVN QNDKEYIQIR ALLKRWVDHF LEDYIKIKHK ISHCIDNGKG
     NICKNKCNDK CNCASKWIDE KRTEWKTIRD RYFEQYKGAQ SDVYDVKGFL EDLQSQIPVT
     INKAIEPCKD LGEFERSTHC NGAASSENGK PQKKDIIECL LDKLEKKTKK CKDDHPQPSA
     ENQAQTCENS AHVEDDDEPL EEEGDQNPVG KQQPSFCPPV EDKKKEEEGE TCTPASPAPA
     PAPSEDPPVP APAGDQKEAS TPKVAPRPKP PRVKPQQPGD DPWEPLKNAM LSSTIMWSIG
     IGFATFTYFY LKKKTKSSVA NLFQILQIPK GDYDIPTLKS SNRYIPYASD RYKGKTYIYM
     EGDSSGDEKY AFMSDTTDVT SSESEYEELD INDIYVPGSP KYKTLIEVVL EPSKRDIPSG
     DIPHTNKFTD NEWNQLKKDF ISNMLQNTQN TEPNVLHDNV DNNTHPTMSR HNVDQKPFIM
     SIHDRNLYIG EEYSYDMSTN SGENNLYSGI DPTSANHDSY SGIDLINDAL NGDYDIYDEI
     LKRKENELFG TNHTKKNTST NSVAKNTNSD PILNQINLFH KWLDRHRNMC EQWDKNKKEE
     FLDKLKKEWN KENNNNSGDI NNRYENVLNT DVSIQIDMHN PKPKNEFTNM DTNPDNFIKD
     TILNDLEKHR EPYFYDIYDD DITYFDTDDV KPPMDDIHIK EQTEMNALHN NKMNELLEKE
     YPISDIWNI
//

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