(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAS4_PLAF7

ID   Q8IAS4_PLAF7            Unreviewed;      2231 AA.
AC   Q8IAS4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 84.
DE   SubName: Full=Erythrocyte membrane protein 1, PfEMP1 {ECO:0000313|EMBL:CAD51286.1};
GN   ORFNames=PF3D7_0808700 {ECO:0000313|EMBL:CAD51286.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51286.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51286.1; -; Genomic_DNA.
DR   RefSeq; XP_001349437.1; XM_001349401.1.
DR   SMR; Q8IAS4; -.
DR   EnsemblProtists; CAD51286; CAD51286; PF3D7_0808700.
DR   GeneDB; PF3D7_0808700.1:pep; -.
DR   GeneID; 2655304; -.
DR   KEGG; pfa:PF3D7_0808700; -.
DR   EuPathDB; PlasmoDB:PF3D7_0808700; -.
DR   HOGENOM; HOG000115239; -.
DR   KO; K13850; -.
DR   OMA; MITSTEE; -.
DR   PhylomeDB; Q8IAS4; -.
DR   Reactome; R-PFA-114608; Platelet degranulation.
DR   Reactome; R-PFA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0020002; C:host cell plasma membrane; TAS:GeneDB.
DR   GO; GO:0020030; C:infected host cell surface knob; TAS:GeneDB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0050839; F:cell adhesion molecule binding; TAS:GeneDB.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0020033; P:antigenic variation; TAS:GeneDB.
DR   GO; GO:0098609; P:cell-cell adhesion; TAS:GeneDB.
DR   GO; GO:0020035; P:cytoadherence to microvasculature, mediated by symbiont protein; TAS:GeneDB.
DR   GO; GO:0020013; P:modulation by symbiont of host erythrocyte aggregation; TAS:GeneDB.
DR   GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR   InterPro; IPR041480; CIDR1_gamma.
DR   InterPro; IPR004258; DBL.
DR   InterPro; IPR008602; Duffy-antigen_binding.
DR   InterPro; IPR029211; PfEMP1_ATS.
DR   InterPro; IPR029210; PfEMP1_NTS.
DR   Pfam; PF15445; ATS; 1.
DR   Pfam; PF18562; CIDR1_gamma; 1.
DR   Pfam; PF05424; Duffy_binding; 2.
DR   Pfam; PF15447; NTS; 1.
DR   Pfam; PF03011; PFEMP; 2.
PE   4: Predicted;
DR   PRODOM; Q8IAS4.
DR   SWISS-2DPAGE; Q8IAS4.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN       12     48       NTS. {ECO:0000259|Pfam:PF15447}.
FT   DOMAIN      627    778       PFEMP. {ECO:0000259|Pfam:PF03011}.
FT   DOMAIN     1428   1474       CIDR1_gamma. {ECO:0000259|Pfam:PF18562}.
FT   DOMAIN     1495   1638       PFEMP. {ECO:0000259|Pfam:PF03011}.
FT   DOMAIN     1770   2231       ATS. {ECO:0000259|Pfam:PF15445}.
FT   COILED      203    230       {ECO:0000256|SAM:Coils}.
FT   COILED      323    343       {ECO:0000256|SAM:Coils}.
FT   COILED      387    407       {ECO:0000256|SAM:Coils}.
FT   COILED      831    851       {ECO:0000256|SAM:Coils}.
FT   COILED     1614   1634       {ECO:0000256|SAM:Coils}.
FT   COILED     1699   1719       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2231 AA;  255972 MW;  9FA26F6A2913FC50 CRC64;
     MAASTTYSSA PDAKHLLDMI GKDVHDQVKK EAKERSKGEL TGQLSFASIL GERAYTTDPC
     QLIKEKRENL IGDRGERHPC GNGSGKGEDV NRFSKERVDE YDNKKMKCSY GSNGKSEGAC
     APFRRLHVCD KNIQQIKTEN ITTHNLLLDV CLAAKYEGES LKGYHEQYEV QYPSSGSTMC
     TELARSFADI GDIVRGRDLY GGSKKEKEKR KQLDDKLKKI FENIKKENNE KLKSLTDDQI
     REYWWTANRE TVWKAITCDE ENKLGGYLYF RGTCGDNEKS VTQARDKCRC KKKDNTPDDQ
     VPTYFDYVPQ YLRWFEEWGE DFCRKKKKKV ENAKKKCRGE NNDKYCSRNG CDCEKTVRAK
     GKLRYGNRCT DCLYACYPYV HWIDKKKEEF DKQVKKYDEE IKKYTKVASG SSRKTRAATI
     KYEGYEKKFY EKLKESDYGK VDKFLEKLSK DKECEKVDDE EGGKINFAEK HDNNNNDEKE
     GTFYRSKYCQ PCPYCGMKKK VPGKEWEKKN DNCTSGKLYE PKGDAEGTPI KILKSGENHD
     DIKQKIDDFC KTEDDESLYA AWKCYKHDEV QKVKREGEEE DDDEEDYKNV KAAGGLCILE
     NQKKKEEGKE KKSEKEPEQF QKTFNDFFTY WVAHMLKDSI YWRTKKIKKC LENGKTMKCR
     NGCNNDCDCF ESWVKQKKEK EWKPIKDHFG KQEDIKQETG MDPGDFLEYY LKLQFFEEVS
     EEKSQTGDED ANEKKRIKEM FDKKNQRTDK VASNEETIID FMLEEELKDA TKCKQDCEQR
     KPPGAGGGDV RSDTVPSRDP LTPGPTDGHE DSEDEEEEEE EEDEEHGPDD KEGTEENVEE
     TETVEDQVEE EKAKDNTDGK GEEEEDNQGE TTQITTQDGV NPCDIVDKLF KDDNTLTNAC
     PTKYEKGREK FPNWKCIPSG DKTDTRERAG RSRRDTSGEN TTTGSSGDTN GSVCVPSRRR
     KLYIQKLHDW AEKQVGTTQV DGKAAQGDAA SKDPKVELRN AFIQSAAVET FFLWHKYKAE
     NTKTQGGVGS LPLQTIDRNS ANGDDEDNPE KQLKEGTIPH GFLRQMFYTL GDYRDILVGK
     YVDNGKDMEE VKSNIDSFFS NGEKPDDKKG VEQRKEWWKE NAKHIWHGMI CALTYDTNTA
     SGDKHTLKQN KSLKEALWDE QKKKPKKTDN GSDYTYESVV LKEDDEGGGP RGQTSSPSSG
     EKTTLNNPKL SDFVLRPPYF RYLEEWGQNF CKERKKRLEK IEEECMEYGS RGKQKQKYSG
     DGEECEKVLV EDANIFSDLS SSCATPCRKY RKWIERKKYE FTEQYNAYGG QKNNYVNEQK
     DKCQTQSNNH DNGFCGTLEK DAAAFLNRLK NGPCKNNNDN GEEHKIDFND TKKTFKHTEY
     CGPCSEFKVK CKNGACGDSN TQKKCNGITP IDGNEIAKMI TSTEEVVMRV SDNSGNRFDG
     DLKEACNGKG IFKSIKENKW ECRNVCGYVV CKPKEGNRET ASGENKDQII TIRALVTHWV
     QNFLDDYKKI KHKISQCTKT DQGSTCQNKC QNKCKCVGEW IPKKREEWEK IRKRFLEQYK
     IENDEDFNVR SCLENFLVQI GAANAKNKVI KLSKFGNSCG CSADASAQKN DGHKDAIDCL
     LQKLQNKIDD CNKNQAQNSV ETQPSDENPA QCQDTHPDDD LLLEEEQNPK NMRPGFCPED
     DTTEQQEEEQ DTCTPAGTVK EEEEEKEEKK DKGDEEEESP SGNSAPDPPE SPSAGPNHNQ
     HPPAIPTPAT PAADPPQADE PFNRDILEKT IPFGVALALG SIAFLFLKKK TKSSVGNLFQ
     ILQIPKSDYD IPTLKSKNRY IPYKSGPYKG KTYIYMEGDS DEDKYAFMSD TTDITSSESE
     YEEMDINDIY VPGSPKYKTL IEVVLEPSGN NTTASGKNTP SDTQNDIQND GIPSSKITDN
     EWNTLKHDFI SNMLQNEPNT EPNILHDNLD NNTHPTMSRD NMEEKPFITS IHDRNLYTGE
     EYNYNVNMVN SMDDTKYVSN NVYSGIDLIN DTLSGNKHID IYDEVLKRKE NELFGTNHVK
     QTSIHSVAKL TNSDPIHKQL DLLHTWLDRH RHMCEKWNNK EELLDKLKKE WNKENNTNSS
     LTHTSNIPSG ENSIKNVLNT DVSIQIDMDN PKPKNEFTNM DTIPDKSTMD TILDDLEKYN
     EPYYYDFYKD DIYYDVNDDD KTSMDDIYVD HNNVTSNNMD VPTKMHIEMN IVNNKNEIFE
     EEYPISDIWN I
//

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