(data stored in SCRATCH zone)

SWISSPROT: Q8IAR7_PLAF7

ID   Q8IAR7_PLAF7            Unreviewed;       373 AA.
AC   Q8IAR7;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 110.
DE   SubName: Full=Tyrosine--tRNA ligase {ECO:0000313|EMBL:CAD51293.1};
DE            EC=6.1.1.1 {ECO:0000313|EMBL:CAD51293.1};
GN   ORFNames=PF3D7_0807900 {ECO:0000313|EMBL:CAD51293.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51293.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000213|PDB:3VGJ}
RP   X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) IN COMPLEX WITH AMP.
RX   PubMed=22068597; DOI=10.1038/ncomms1522;
RA   Bhatt T.K., Khan S., Dwivedi V.P., Banday M.M., Sharma A., Chandele A.,
RA   Camacho N., Ribas de Pouplana L., Wu Y., Craig A.G., Mikkonen A.T.,
RA   Maier A.G., Yogavel M., Sharma A.;
RT   "Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-
RT   inflammatory responses.";
RL   Nat. Commun. 2:530-530(2011).
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|RuleBase:RU363036}.
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DR   EMBL; AL844507; CAD51293.1; -; Genomic_DNA.
DR   RefSeq; XP_001349444.1; XM_001349408.1.
DR   PDB; 3VGJ; X-ray; 2.21 A; A/B=1-373.
DR   PDBsum; 3VGJ; -.
DR   SMR; Q8IAR7; -.
DR   IntAct; Q8IAR7; 1.
DR   PRIDE; Q8IAR7; -.
DR   EnsemblProtists; CAD51293; CAD51293; PF3D7_0807900.
DR   GeneDB; PF3D7_0807900.1:pep; -.
DR   GeneID; 2655248; -.
DR   KEGG; pfa:PF3D7_0807900; -.
DR   EuPathDB; PlasmoDB:PF3D7_0807900; -.
DR   HOGENOM; HOG000228238; -.
DR   InParanoid; Q8IAR7; -.
DR   KO; K01866; -.
DR   OMA; YIGFEIS; -.
DR   PhylomeDB; Q8IAR7; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0044164; C:host cell cytosol; IDA:GeneDB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046789; F:host cell surface receptor binding; IDA:GeneDB.
DR   GO; GO:0004831; F:tyrosine-tRNA ligase activity; IDA:GeneDB.
DR   GO; GO:0006437; P:tyrosyl-tRNA aminoacylation; ISS:GeneDB.
DR   Gene3D; 3.40.50.620; -; 2.
DR   InterPro; IPR002305; aa-tRNA-synth_Ic.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR023617; Tyr-tRNA-ligase_arc/euk-type.
DR   Pfam; PF00579; tRNA-synt_1b; 1.
DR   PIRSF; PIRSF006588; TyrRS_arch_euk; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q8IAR7.
DR   SWISS-2DPAGE; Q8IAR7.
KW   3D-structure {ECO:0000213|PDB:3VGJ};
KW   Aminoacyl-tRNA synthetase {ECO:0000256|RuleBase:RU363036};
KW   ATP-binding {ECO:0000256|RuleBase:RU363036};
KW   Ligase {ECO:0000256|RuleBase:RU363036, ECO:0000313|EMBL:CAD51293.1};
KW   Nucleotide-binding {ECO:0000213|PDB:3VGJ, ECO:0000256|RuleBase:RU363036};
KW   Protein biosynthesis {ECO:0000256|RuleBase:RU363036};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   NP_BIND         61..64
FT                   /note="AMP"
FT                   /evidence="ECO:0000213|PDB:3VGJ"
FT   NP_BIND         207..209
FT                   /note="AMP"
FT                   /evidence="ECO:0000213|PDB:3VGJ"
FT   NP_BIND         235..238
FT                   /note="AMP"
FT                   /evidence="ECO:0000213|PDB:3VGJ"
FT   NP_BIND         247..248
FT                   /note="AMP"
FT                   /evidence="ECO:0000213|PDB:3VGJ"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  43453 MW;  0A85854DE8F4DFEE CRC64;
     METTDTKREE QEIEEKKAQE ESKIEDVDKI LNDILSISSE CIQPDELRVK LLLKRKLICY
     DGFEPSGRMH IAQGLLKSII VNKLTSNGCT FIFWIADWFA HLNNKMSGDL KKIKKVGSYF
     IEVWKSCGMN MENVQFLWAS EEINKKPNEY WSLVLDISRS FNINRMKRCL KIMGRSEGEE
     NYCSQILYPC MQCADIFFLN VDICQLGIDQ RKVNMLAREY CDIKKIKKKP VILSHGMLPG
     LLEGQEKMSK SDENSAIFMD DSESDVNRKI KKAYCPPNVI ENNPIYAYAK SIIFPSYNEF
     NLVRKEKNGG DKTYYTLQEL EHDYVNGFIH PLDLKDNVAM YINKLLQPVR DHFQNNIEAK
     NLLNEIKKYK VTK
//

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