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ID Q8IAR3_PLAF7 Unreviewed; 260 AA.
AC Q8IAR3;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 2.
DT 08-MAY-2019, entry version 114.
DE RecName: Full=Proteasome endopeptidase complex {ECO:0000256|PROSITE-ProRule:PRU00808};
DE EC=3.4.25.1 {ECO:0000256|PROSITE-ProRule:PRU00808};
GN ORFNames=PF3D7_0807500 {ECO:0000313|EMBL:CAD51297.2};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51297.2, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium
RT falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000213|PDB:5FMG}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS).
RX PubMed=26863983; DOI=10.1038/NATURE16936;
RA Li H., O'Donoghue A.J., van der Linden W.A., Xie S.C., Yoo E.,
RA Foe I.T., Tilley L., Craik C.S., da Fonseca P.C., Bogyo M.;
RT "Structure- and function-based design of Plasmodium-selective
RT proteasome inhibitors.";
RL Nature 530:233-236(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of peptide bonds with very broad specificity.;
CC EC=3.4.25.1; Evidence={ECO:0000256|PROSITE-ProRule:PRU00808};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00594407}.
CC -!- SIMILARITY: Belongs to the peptidase T1A family.
CC {ECO:0000256|PROSITE-ProRule:PRU00808}.
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DR EMBL; AL844507; CAD51297.2; -; Genomic_DNA.
DR RefSeq; XP_001349448.2; XM_001349412.2.
DR PDB; 5FMG; EM; 3.60 A; A/O=1-260.
DR PDBsum; 5FMG; -.
DR SMR; Q8IAR3; -.
DR DIP; DIP-43027N; -.
DR IntAct; Q8IAR3; 2.
DR PRIDE; Q8IAR3; -.
DR EnsemblProtists; CAD51297; CAD51297; PF3D7_0807500.
DR GeneDB; PF3D7_0807500.1:pep; -.
DR GeneID; 2655251; -.
DR KEGG; pfa:PF3D7_0807500; -.
DR EuPathDB; PlasmoDB:PF3D7_0807500; -.
DR HOGENOM; HOG000091084; -.
DR InParanoid; Q8IAR3; -.
DR KO; K02730; -.
DR OMA; MSRTSYD; -.
DR PhylomeDB; Q8IAR3; -.
DR Reactome; R-PFA-5689603; UCH proteinases.
DR Reactome; R-PFA-5689880; Ub-specific processing proteases.
DR Reactome; R-PFA-68949; Orc1 removal from chromatin.
DR Proteomes; UP000001450; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005839; C:proteasome core complex; ISS:GeneDB.
DR GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; IBA:GO_Central.
DR GO; GO:0004175; F:endopeptidase activity; ISS:GeneDB.
DR GO; GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central.
DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:GeneDB.
DR CDD; cd03754; proteasome_alpha_type_6; 1.
DR Gene3D; 3.60.20.10; -; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR023332; Proteasome_alpha-type.
DR InterPro; IPR000426; Proteasome_asu_N.
DR InterPro; IPR001353; Proteasome_sua/b.
DR InterPro; IPR034642; Proteasome_subunit_alpha6.
DR Pfam; PF00227; Proteasome; 1.
DR Pfam; PF10584; Proteasome_A_N; 1.
DR SMART; SM00948; Proteasome_A_N; 1.
DR SUPFAM; SSF56235; SSF56235; 1.
DR PROSITE; PS51475; PROTEASOME_ALPHA_2; 1.
PE 1: Evidence at protein level;
DR PRODOM; Q8IAR3.
DR SWISS-2DPAGE; Q8IAR3.
KW 3D-structure {ECO:0000213|PDB:5FMG};
KW Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW Cytoplasm {ECO:0000256|PROSITE-ProRule:PRU00808};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00808,
KW ECO:0000313|EMBL:CAD51297.2};
KW Nucleus {ECO:0000256|SAAS:SAAS00136223};
KW Protease {ECO:0000256|PROSITE-ProRule:PRU00808};
KW Proteasome {ECO:0000256|PROSITE-ProRule:PRU00808,
KW ECO:0000313|EMBL:CAD51297.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Threonine protease {ECO:0000256|PROSITE-ProRule:PRU00808}.
FT DOMAIN 9 31 PROTEASOME_ALPHA_1. {ECO:0000259|SMART:
FT SM00948}.
SQ SEQUENCE 260 AA; 29500 MW; 7236D13D35BCBC14 CRC64;
MVRPSQSMYD RHLTIFSPDG NLYQIEYAIK AVKNTNITSV GVKGENCAVI ISQKKMATQY
ISQDKLLDYN NITNIYNITD EIGCSMVGMP GDCLSMVYKA RSEASEFLYS NGYNVNAETL
CRNICDKIQV YTQHAYMRLH ACSGMIIGID ENNKPELFKF DPSGFCAGYR ACVIGNKEQE
SISVLERLLE KRKKKIQQET IDEDIRNTTI LAIEALQTIL AFDLKASEIE VAIVSTKNRN
FTQISEKEID NYLTYIAERD
//
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