(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAQ8_PLAF7

ID   Q8IAQ8_PLAF7            Unreviewed;      1053 AA.
AC   Q8IAQ8;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 97.
DE   SubName: Full=Vacuolar proton translocating ATPase subunit A,putative {ECO:0000313|EMBL:CAD51303.1};
DE            EC=3.6.3.14 {ECO:0000313|EMBL:CAD51303.1};
GN   ORFNames=PF3D7_0806800 {ECO:0000313|EMBL:CAD51303.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51303.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51303.1; -; Genomic_DNA.
DR   RefSeq; XP_001349454.1; XM_001349418.1.
DR   IntAct; Q8IAQ8; 4.
DR   SwissPalm; Q8IAQ8; -.
DR   PRIDE; Q8IAQ8; -.
DR   EnsemblProtists; CAD51303; CAD51303; PF3D7_0806800.
DR   GeneDB; PF3D7_0806800.1:pep; -.
DR   GeneID; 4794196; -.
DR   KEGG; pfa:PF3D7_0806800; -.
DR   EuPathDB; PlasmoDB:PF3D7_0806800; -.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; Q8IAQ8; -.
DR   KO; K02154; -.
DR   OMA; INARHFK; -.
DR   PhylomeDB; Q8IAQ8; -.
DR   BioCyc; PLASMO:PF08_0113-MONOMER; -.
DR   Reactome; R-PFA-1222556; ROS and RNS production in phagocytes.
DR   Reactome; R-PFA-6798695; Neutrophil degranulation.
DR   Reactome; R-PFA-77387; Insulin receptor recycling.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; ISS:GeneDB.
DR   GO; GO:0016469; C:proton-transporting two-sector ATPase complex; ISS:GeneDB.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0009055; F:electron transfer activity; ISS:GeneDB.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; ISS:GeneDB.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; ISS:GeneDB.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; ISS:GeneDB.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   4: Predicted;
DR   PRODOM; Q8IAQ8.
DR   SWISS-2DPAGE; Q8IAQ8.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Hydrolase {ECO:0000313|EMBL:CAD51303.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    486    510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    531    549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    620    641       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    653    676       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    714    737       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    989   1009       Helical. {ECO:0000256|SAM:Phobius}.
FT   COILED       48     68       {ECO:0000256|SAM:Coils}.
FT   COILED      329    356       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1053 AA;  122999 MW;  8B9F2559D3FC3F08 CRC64;
     MGIFRSEIMK HGTLVLPSDR AREYLDCLGK EVDIQFIDMN EKTMKRQYKK YIQRIDDMER
     ILRFLEENIN KLPNVKIKKS KIDNFLEHDN IYELDQVEES LNRLHVQFVR FCNNNKDLID
     EKNNAIEEKH VILTALNQLS PGFIRGVGGL RGSVIGGDQQ QQHHHNNNNN NNIVSPFDEG
     IEENNISLST HIMKDGINMM FTNISGVIKT KDQESFSRTI FRAFRGNTYT YFQNIDEDAD
     DNDLLKNVEE LESLKSAGDT NNMYKNNKQH DTFSDKLDGK DKNDKKKKKD LKSVFVVYCQ
     GSAQSNIYDK IMKICKAYDV KTYDWPRTYE HAKKRLKELR EIINDKEKAL KAYEEYFINE
     IFVLINVVEP NKNSLIEEWK LFCKKERHIY NNLNYFEGSD ITLRCDCWYS ANDEEKIRHI
     LINKSSNDLV SALLLSDKIL RPNVSPPTYI KTNEFTKSYQ SMVDTYGVPR YGEINPAIST
     IITFPFLFGI MYGDVGHGLC IFLFALFLII MNNKVKNKKN NNEMVTMLFD GRYMLLLMGF
     FAVYAGFLYN DFFSMPLNLF SSMFMLDKQV DNMEYYKRRE ITDSATGEVQ YAYPYIFGFD
     CKWLGAENEL TYINSFKMKF SIIIGFIHMT FGVLMKGFNA LHFKRKMDFF FEFLPQLVMM
     LSMIGYLVFL IIYKWVTPVG YGGFQKQGII NTIINMYLMK EINSTNQFYP YQSIIQILLL
     SLFVLCIPFM FICKPAIRTY HIMKEKQKIN DHNVHKKNRR GKKAMAKRNN NNNNNNNNQN
     DNKNMLLTNQ NFNEAGAKEM INAFHHNAKT GGILLSTNSK KKIVTSDGNH NNNLLSMHKR
     NTMNNKISSS PYHNEQPDDV YDQYDEYDDD DDDDNYDENE YLNKKKKKRT DDDIEAHLLS
     STYEEKGLQS SSAAMRGGGA GEENHHEENI SEIWIEQLIE TIEFILGLIS NTASYLRLWA
     LSLAHQQLSF VFFEQTILNS LKRNSFMSVL INLILFSQLF SILTIAVILC MDTLECFLHS
     LRLQWVEFQN KFYKGDGIPF KPFNIKKLLN ENE
//

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