(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAP4_PLAF7

ID   Q8IAP4_PLAF7            Unreviewed;       491 AA.
AC   Q8IAP4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 96.
DE   SubName: Full=GTPase-activating protein, putative {ECO:0000313|EMBL:CAD51317.1};
GN   ORFNames=PF3D7_0804900 {ECO:0000313|EMBL:CAD51317.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51317.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51317.1; -; Genomic_DNA.
DR   RefSeq; XP_001349468.1; XM_001349432.1.
DR   SMR; Q8IAP4; -.
DR   IntAct; Q8IAP4; 1.
DR   PRIDE; Q8IAP4; -.
DR   EnsemblProtists; CAD51317; CAD51317; PF3D7_0804900.
DR   GeneDB; PF3D7_0804900.1:pep; -.
DR   GeneID; 2655319; -.
DR   KEGG; pfa:PF3D7_0804900; -.
DR   EuPathDB; PlasmoDB:PF3D7_0804900; -.
DR   HOGENOM; HOG000284478; -.
DR   InParanoid; Q8IAP4; -.
DR   OMA; DDTIFEH; -.
DR   BioCyc; PLASMO:PF08_0120-MONOMER; -.
DR   Reactome; R-PFA-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0000139; C:Golgi membrane; IEA:GOC.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048205; P:COPI coating of Golgi vesicle; IBA:GO_Central.
DR   Gene3D; 3.30.40.160; -; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   Pfam; PF01412; ArfGap; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SUPFAM; SSF57863; SSF57863; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
PE   4: Predicted;
DR   PRODOM; Q8IAP4.
DR   SWISS-2DPAGE; Q8IAP4.
KW   Metal-binding {ECO:0000256|SAAS:SAAS01005981};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Zinc {ECO:0000256|SAAS:SAAS01005948};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          26..107
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REGION          148..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   491 AA;  56501 MW;  C4663544C2FE1F67 CRC64;
     MKKSLIEEVL EYEQDNRGYV LDTLKDKTFK IILNKNENKN CFDCGNKNPK WLSLTYAIFI
     CLNCSGKHRQ LGTHISFVRS TGMDKFTAKQ LIRICLGGNM KASEYLKRSK DSIIDYSSHV
     CLKYKMYLDN LLEEILLNYS KGVKSVEFDN NNKNNNNSNN SSNHMNSGVS NNLSMNRRQP
     IDLISDDIKG DEMLTSFENV QNNENDFSST FFGFNNNSKK MEINQNNNNN NNNSNVFVPT
     HFIDEKVAFN NNSNKNFKAK KIDINFDNIF EQGDIINNNN NNNNNNNVNN NYSGNPNLDN
     SLKLYATNQK EQQNNLEGIR GSMYDNNNSY NNMYAYNNEH YMDNQHNAYG NRMSNPNNYL
     NSNGNNNNNN NGYGYGYGFN NKSSFSNNNF NVTTDSKLNK FKDCKSIRSD QYFYDEMPRN
     EHVMPNVHIA DSISSDQYFN KNVNNKKGVW NLDEQTVQNL QGLKVSAREG ISNIVAAGNE
     VFLKAKEWFN N
//

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