(data stored in ACNUC9543 zone)

SWISSPROT: Q7K6A9_PLAF7

ID   Q7K6A9_PLAF7            Unreviewed;       265 AA.
AC   Q7K6A9;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   08-MAY-2019, entry version 113.
DE   RecName: Full=Proteasome subunit beta {ECO:0000256|PIRNR:PIRNR001213};
DE            EC=3.4.25.1 {ECO:0000256|PIRNR:PIRNR001213};
GN   ORFNames=PF3D7_0803800 {ECO:0000313|EMBL:CAD51325.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51325.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000213|PDB:5FMG}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS).
RX   PubMed=26863983; DOI=10.1038/NATURE16936;
RA   Li H., O'Donoghue A.J., van der Linden W.A., Xie S.C., Yoo E.,
RA   Foe I.T., Tilley L., Craik C.S., da Fonseca P.C., Bogyo M.;
RT   "Structure- and function-based design of Plasmodium-selective
RT   proteasome inhibitors.";
RL   Nature 530:233-236(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleavage of peptide bonds with very broad specificity.;
CC         EC=3.4.25.1; Evidence={ECO:0000256|PIRNR:PIRNR001213};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR001213}.
CC       Nucleus {ECO:0000256|PIRNR:PIRNR001213,
CC       ECO:0000256|SAAS:SAAS00551005}.
CC   -!- SIMILARITY: Belongs to the peptidase T1B family.
CC       {ECO:0000256|PIRNR:PIRNR001213}.
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DR   EMBL; AL844507; CAD51325.1; -; Genomic_DNA.
DR   RefSeq; XP_001349476.1; XM_001349440.1.
DR   PDB; 5FMG; EM; 3.60 A; N/b=1-265.
DR   PDBsum; 5FMG; -.
DR   SMR; Q7K6A9; -.
DR   DIP; DIP-61946N; -.
DR   IntAct; Q7K6A9; 1.
DR   PRIDE; Q7K6A9; -.
DR   EnsemblProtists; CAD51325; CAD51325; PF3D7_0803800.
DR   GeneDB; PF3D7_0803800.1:pep; -.
DR   GeneID; 2655367; -.
DR   KEGG; pfa:PF3D7_0803800; -.
DR   EuPathDB; PlasmoDB:PF3D7_0803800; -.
DR   HOGENOM; HOG000181719; -.
DR   InParanoid; Q7K6A9; -.
DR   KO; K02736; -.
DR   OMA; NWDIAHL; -.
DR   PhylomeDB; Q7K6A9; -.
DR   Reactome; R-PFA-5689603; UCH proteinases.
DR   Reactome; R-PFA-5689880; Ub-specific processing proteases.
DR   Reactome; R-PFA-68949; Orc1 removal from chromatin.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005839; C:proteasome core complex; IBA:GO_Central.
DR   GO; GO:0004175; F:endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central.
DR   GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd03760; proteasome_beta_type_4; 1.
DR   Gene3D; 3.60.20.10; -; 1.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR016295; Proteasome_beta4.
DR   InterPro; IPR016050; Proteasome_bsu_CS.
DR   InterPro; IPR001353; Proteasome_sua/b.
DR   InterPro; IPR023333; Proteasome_suB-type.
DR   PANTHER; PTHR11599:SF5; PTHR11599:SF5; 1.
DR   Pfam; PF00227; Proteasome; 2.
DR   PIRSF; PIRSF001213; Psome_endopept_beta; 2.
DR   SUPFAM; SSF56235; SSF56235; 1.
DR   PROSITE; PS00854; PROTEASOME_BETA_1; 1.
DR   PROSITE; PS51476; PROTEASOME_BETA_2; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q7K6A9.
DR   SWISS-2DPAGE; Q7K6A9.
KW   3D-structure {ECO:0000213|PDB:5FMG};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR001213};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001213,
KW   ECO:0000313|EMBL:CAD51325.1};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR001213,
KW   ECO:0000256|SAAS:SAAS00435711};
KW   Protease {ECO:0000256|PIRNR:PIRNR001213};
KW   Proteasome {ECO:0000313|EMBL:CAD51325.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Threonine protease {ECO:0000256|PIRNR:PIRNR001213}.
SQ   SEQUENCE   265 AA;  30872 MW;  7B4FD041159FF175 CRC64;
     MTLGPVVTGT SVIAIKYKHG IMIAADRKAS YGSYAKFQNV ERIFKINNKT VMGFSGELAD
     AQYLHELLTR KNINNLSEKK RKEDMYTPQH YHSYVSRVFY VRKNRIDPLF NNIIIAGINS
     QKYDNNDDNV LLYTNKNNDD EQNEYKNNEE YKEIHKDDLY IGFVDMHGTN FCDDYITTGY
     ARYFALTLLR DHYKDNMTEE EARILINECL RILYFRDATS SNFIQIVKVT SKGVEYEEPY
     ILPCVLNSAD YVYPSTLLPP AGCMW
//

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