(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAN5_PLAF7

ID   Q8IAN5_PLAF7            Unreviewed;      1467 AA.
AC   Q8IAN5;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 105.
DE   SubName: Full=AAA family ATPase, putative {ECO:0000313|EMBL:CAD51328.1};
GN   ORFNames=PF3D7_0803500 {ECO:0000313|EMBL:CAD51328.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51328.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51328.1; -; Genomic_DNA.
DR   RefSeq; XP_001349479.1; XM_001349443.1.
DR   IntAct; Q8IAN5; 1.
DR   EnsemblProtists; CAD51328; CAD51328; PF3D7_0803500.
DR   GeneDB; PF3D7_0803500.1:pep; -.
DR   GeneID; 2655369; -.
DR   KEGG; pfa:PF3D7_0803500; -.
DR   EuPathDB; PlasmoDB:PF3D7_0803500; -.
DR   InParanoid; Q8IAN5; -.
DR   OMA; DDNKCDD; -.
DR   BioCyc; PLASMO:MAL8P1.144-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004176; F:ATP-dependent peptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   Pfam; PF00004; AAA; 2.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
PE   4: Predicted;
DR   PRODOM; Q8IAN5.
DR   SWISS-2DPAGE; Q8IAN5.
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        448..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          695..953
FT                   /note="AAA"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          30..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1016..1080
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1259..1364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1022..1067
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1261..1279
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1280..1294
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1307..1344
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1467 AA;  175575 MW;  514C19D76F2D60C9 CRC64;
     MKKKNERKTN VEQAMSDYLL NLSQIYNQSN SFSDYDNNNN DNNNDNNNNN NNNNNNMRYL
     KFNNFRIDNM MKKNGCELFV KDNKNYIDNK KMELSYYDKV MNNIFSKKER EIYRNIQNII
     KTQERNDINL EVNEYLYSYL FILAIKKMFY DIIAQKKMEC HINIMHNQNI NKTNFQKKDI
     YKTTNNNLYK LKYNSNEKNV HQNEHAYYSK DIKIGTHELT HNMDNIKKNI HHEQSVNNLH
     NDDHVKGTNM DDQNNFKENF KKKFYHHKLK NLDSRTTGSF NSIDSKNEGS KGDDNKCDDN
     KCDDNKCDDN KCDDNKCDDN KCDDNKCDDN KCDDNKCDDN KCDDNKCDDN KCDDNKCDDN
     KCDDNKCDDN KCDDNKCDDN KCDYNQCNTN QRNTNLRNTN QHNDVPKDEI TNNVSHKDDT
     NKIHSNKSKN FYKDYIMVLY NTMKKNKYYW LVPLSVISCI YIYYKMRVRV CFFFKNTYSN
     VCRFMTNIFF NNNGLHGNKN LILKDYNHFF NNINRNNVKT ILFNPSSNTF TYMLDKNVPK
     TSGLMIYNNR LNNNENGSVG SSWLSSPSPS SSSSTHNNNI LYMIYYNDYI MKYLLKNKVY
     EHVDFRVDDK LLKLSIYDII RRNIFDILTY TFSILTFYYI YEKNILNCNN VDYSFEKQKK
     LQSLNDIILN DNIKREIKSM LFFVLYSKMF NEPFSCDTIL FSGDTGTGKT MLAKTMAKEL
     NFDFLHVSGS TFIELYIGSG ASKIRTLFKK AKKNNKPMVI FIDEIDSIGI SRCMNNDMSF
     SNQEYAQTLN QLLIELDSLH EYNKIHMLSE QNKQWNIFMY IKNKLINNIY GKENKTHNNN
     NNNIHDGNGD QLLYGKDHKI SRKYSSYYNN TSDDYPTNNH KDHIDEKKAY DIYNYYLNND
     LSIYEIEELF NLKNYRTQHF ILFIGATNRY KQLDSALIRA KRFDKVIHFN LPNINTRMKL
     FSFYINKYIK RNITCNQISK KKNDLPVSPN GYASYMNPDF NYYESHQENE FTYVKQTGST
     KNEINKYDDD DNNNDDHNND DHNNDDHNND DHDKHHQPCD GNRLHNHINN HKNKNNNLKN
     KNTLMYPIQP YNKYNEQYYK HFNYFNFSYD LKYRPTLSPF IINKNKKVHE QNTNIYNFID
     IFTLSILTFH FNCADIDQLT YSVKSNLMTK NIINKKEFNV NNLLMINLDD MLHKKFTYDS
     HLDKIVSQKN SDEQEHFSSS LNNRILNACN VDAEEYFHKF LTYCNNIFLD KIKHIRKKQM
     NRNKKDETVG DKNIKKCTKN EDNNNNNNNN DDNNNDDDNN NDDNIYNNDD DNYHDNFHDD
     NYYDDNYYDD NYHDDNFHDD NYYDDDYHDD TDEQNNNEYY NKDDTKKNIN DLHFTNDKYM
     HYNYNNYNNN KINMDCYLSY DDLLLLYESK KIKLHVWDDN LNDVHNNNLN IHNNNSFFNE
     HIQYCILWKS IQTYFNTLHI NYKNITF
//

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