(data stored in SCRATCH zone)

SWISSPROT: Q8IAM8_PLAF7

ID   Q8IAM8_PLAF7            Unreviewed;       604 AA.
AC   Q8IAM8;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 109.
DE   RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE            EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN   ORFNames=PF3D7_0802800 {ECO:0000313|EMBL:CAD51335.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51335.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC         Evidence={ECO:0000256|RuleBase:RU004273};
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC       {ECO:0000256|RuleBase:RU004273}.
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DR   EMBL; AL844507; CAD51335.1; -; Genomic_DNA.
DR   RefSeq; XP_001349486.1; XM_001349450.1.
DR   IntAct; Q8IAM8; 3.
DR   PRIDE; Q8IAM8; -.
DR   EnsemblProtists; CAD51335; CAD51335; PF3D7_0802800.
DR   GeneDB; PF3D7_0802800.1:pep; -.
DR   GeneID; 2655328; -.
DR   KEGG; pfa:PF3D7_0802800; -.
DR   EuPathDB; PlasmoDB:PF3D7_0802800; -.
DR   HOGENOM; HOG000172699; -.
DR   InParanoid; Q8IAM8; -.
DR   KO; K04348; -.
DR   OMA; LWSLKIW; -.
DR   PhylomeDB; Q8IAM8; -.
DR   Reactome; R-PFA-2871809; FCERI mediated Ca+2 mobilization.
DR   Reactome; R-PFA-4086398; Ca2+ pathway.
DR   Reactome; R-PFA-5607763; CLEC7A (Dectin-1) induces NFAT activation.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005955; C:calcineurin complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004723; F:calcium-dependent protein serine/threonine phosphatase activity; ISS:GeneDB.
DR   GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR   GO; GO:0033192; F:calmodulin-dependent protein phosphatase activity; IBA:GO_Central.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; ISS:GeneDB.
DR   GO; GO:0097720; P:calcineurin-mediated signaling; IBA:GO_Central.
DR   GO; GO:0006470; P:protein dephosphorylation; ISS:GeneDB.
DR   CDD; cd07416; MPP_PP2B; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR041751; MPP_PP2B.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8IAM8.
DR   SWISS-2DPAGE; Q8IAM8.
KW   Hydrolase {ECO:0000256|RuleBase:RU004273, ECO:0000313|EMBL:CAD51335.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          144..149
FT                   /note="SER_THR_PHOSPHATASE"
FT                   /evidence="ECO:0000259|PROSITE:PS00125"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..437
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..458
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..474
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..490
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..514
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        515..529
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   604 AA;  70075 MW;  7DE238301D1D7109 CRC64;
     MEPLPDPKND RQVKDVEPPP AKPLSLELLY PNGTEEPPDY KALRDHLKKE GRIRKEDCLD
     IIKKVIDIVS NEPNLLRLKD PITIVGDIHG QYYDLLKLLE VGGNPDHTQF LFLGDYVDRG
     SFSIEVLLLL YALKINFPDR IWLIRGNHEC RQMTTFFNFR DECEYKYDIV VYYAFMESFD
     TIPLSAVING KFLGVHGGLS PDLILLNQIC SFTRFQEPPR SGIFCDILWS DPIDEDKEEH
     TIQTESYFPN DIRGCSYFFG YNAATTFLEK NGLLSIIRAH EAQLEGYKMH QTNLKTGFPI
     VITIFSAPNY CDVYNNKGAV LKFDSNTLNI QQFSFSPHPY HLPNFMNLFT WSLPFVSEKV
     TEMLYSLLNC SMNDTDEGIN DIVLPKEVIQ ILNYIEENNK RINEMNFNNN DDNVQYEDNG
     PYINQSNNNN NNNNKDNKFD DITYDDHKKE KDKRNKISSN GNMQDNNQLY DHSEGHNNYN
     DEDEFFKNVK KTDTNNNNNN EEEDEEEDEE EEEDGRKTKD VGQVSKERTD TLRKKVQSVG
     RLMRVFRTLR KENELIVQLK GCSPGYRIPV GLLLSGKEGL ENELEKFTKV KEIDSINEKR
     PSNE
//

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