(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAM4_PLAF7

ID   Q8IAM4_PLAF7            Unreviewed;       714 AA.
AC   Q8IAM4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 94.
DE   RecName: Full=Cyclin N-terminal domain-containing protein {ECO:0000259|Pfam:PF00134};
GN   ORFNames=PF3D7_0802400 {ECO:0000313|EMBL:CAD51339.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51339.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51339.1; -; Genomic_DNA.
DR   RefSeq; XP_001349490.1; XM_001349454.1.
DR   SMR; Q8IAM4; -.
DR   IntAct; Q8IAM4; 3.
DR   EnsemblProtists; CAD51339; CAD51339; PF3D7_0802400.
DR   GeneDB; PF3D7_0802400.1:pep; -.
DR   GeneID; 2655399; -.
DR   KEGG; pfa:PF3D7_0802400; -.
DR   EuPathDB; PlasmoDB:PF3D7_0802400; -.
DR   InParanoid; Q8IAM4; -.
DR   OMA; LHEQNGD; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR006671; Cyclin_N.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SUPFAM; SSF47954; SSF47954; 1.
PE   4: Predicted;
DR   PRODOM; Q8IAM4.
DR   SWISS-2DPAGE; Q8IAM4.
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        238..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        273..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          227..293
FT                   /note="Cyclin N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00134"
FT   REGION          80..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          534..554
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        80..108
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..136
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   714 AA;  84335 MW;  B550037C8D13E67F CRC64;
     MKIFQTNVDN FNLNICEQNE NIILKKKEIQ ENINETCGHV EYIKNDIQQN EDPCYNDNNT
     CFDDDIFLRS RKSVPSAFTH KISDDDMDKK RVPEQNDVDN KNDIKRDNNN NYSNDNNYSN
     NNNNNNNNNN IVNDDISMSP KKKKAKYNNT GKDKNEDDNS NNCNNCNNCN DGNDSCDDNS
     HHNPNNVNRL REEIKKELFN KLNIILDVNM NMNTDEEYYM KFLKKKKFRN YIMNTSKFII
     ILGKYLQLSF CTICIALYYM NKYNQKILKR KKNSISYLIA GACIFLAWKL REDFELLKKS
     RKLYDIPKVI FKLLNYFYKK KKLKKKIHSI ELDIITNYKI NHTFYNTQLF NHKTFSSFME
     HMKKEDTYID TKKESKNRKQ SNGSQINNNL NNVQKNKSIY NDLQELNNII QEGYISDINN
     INHVSDCFSS YLSECNSSDV SEYDQMKPEQ DEPINIQTDV KDENGKMGSQ HCDVKRENIK
     IKHEMNGDLH EQNGKLHEQN GDLHEQNGKL HEQNGKLHEQ NGDLHDQSGD LHEQNSLTEN
     IKKFKKLCKE HKKNIYVSSS KWVLNNSGQK LQLMQKIIIY YEGEILKSFN YYIKPKMLFF
     ELLPSYINKF VYTMKGYIEL DQVVYLEKLC LLTILDIYKT PLCLIFTPKE ILITCILKAY
     ISLKLLSNQL HIRSLSFQDF EDKINSFIQS VCCEDPINVY RIKTALRELR QLHF
//

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