(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAM2_PLAF7

ID   Q8IAM2_PLAF7            Unreviewed;       220 AA.
AC   Q8IAM2;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 98.
DE   SubName: Full=1-cys peroxiredoxin {ECO:0000313|EMBL:CAD51341.1};
DE            EC=1.11.1.15 {ECO:0000313|EMBL:CAD51341.1};
GN   ORFNames=PF3D7_0802200 {ECO:0000313|EMBL:CAD51341.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51341.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51341.1; -; Genomic_DNA.
DR   RefSeq; XP_001349492.1; XM_001349456.1.
DR   SMR; Q8IAM2; -.
DR   SwissPalm; Q8IAM2; -.
DR   PRIDE; Q8IAM2; -.
DR   EnsemblProtists; CAD51341; CAD51341; PF3D7_0802200.
DR   GeneDB; PF3D7_0802200.1:pep; -.
DR   GeneID; 2655354; -.
DR   KEGG; pfa:PF3D7_0802200; -.
DR   EuPathDB; PlasmoDB:PF3D7_0802200; -.
DR   HOGENOM; HOG000022346; -.
DR   InParanoid; Q8IAM2; -.
DR   KO; K11188; -.
DR   OMA; YPIIADD; -.
DR   PhylomeDB; Q8IAM2; -.
DR   BioCyc; PLASMO:PF08_0131-MONOMER; -.
DR   Reactome; R-PFA-3299685; Detoxification of Reactive Oxygen Species.
DR   Reactome; R-PFA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB.
DR   GO; GO:0016209; F:antioxidant activity; ISS:GeneDB.
DR   GO; GO:0004601; F:peroxidase activity; ISS:GeneDB.
DR   GO; GO:0051920; F:peroxiredoxin activity; IEA:UniProtKB-EC.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IBA:GO_Central.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; ISS:GeneDB.
DR   InterPro; IPR000866; AhpC/TSA.
DR   InterPro; IPR024706; Peroxiredoxin_AhpC-typ.
DR   InterPro; IPR019479; Peroxiredoxin_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF10417; 1-cysPrx_C; 1.
DR   Pfam; PF00578; AhpC-TSA; 1.
DR   PIRSF; PIRSF000239; AHPC; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   4: Predicted;
DR   PRODOM; Q8IAM2.
DR   SWISS-2DPAGE; Q8IAM2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Oxidoreductase {ECO:0000313|EMBL:CAD51341.1};
KW   Peroxidase {ECO:0000313|EMBL:CAD51341.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN        3    166       Thioredoxin. {ECO:0000259|PROSITE:
FT                                PS51352}.
FT   ACT_SITE     47     47       Cysteine sulfenic acid (-SOH)
FT                                intermediate. {ECO:0000256|PIRSR:
FT                                PIRSR000239-1}.
SQ   SEQUENCE   220 AA;  25164 MW;  ECDA692845B8A15F CRC64;
     MAYHLGATFP NFTATASNVD GVFDFYKYVG DNWAILFSHP HDFTPVCTTE LAEFGKMHEE
     FLKLNCKLIG FSCNSKESHD QWIEDIKFYG NLDKWDIPMV CDESRELANQ LKIMDEKEKD
     IKGLPLTCRC VFFISPDKKV KATVLYPATT GRNSQEILRV LKSLQLTNTH PVATPVNWKE
     GDKCCILPSV DNADLPKLFK NEVKKLDVPS QKAYLRFVQM
//

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