(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAM0_PLAF7

ID   Q8IAM0_PLAF7            Unreviewed;      1397 AA.
AC   Q8IAM0;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 100.
DE   SubName: Full=Glutamate dehydrogenase, putative {ECO:0000313|EMBL:CAD51343.1};
DE            EC=1.4.1.2 {ECO:0000313|EMBL:CAD51343.1};
GN   ORFNames=PF3D7_0802000 {ECO:0000313|EMBL:CAD51343.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51343.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51343.1; -; Genomic_DNA.
DR   RefSeq; XP_001349494.1; XM_001349458.1.
DR   IntAct; Q8IAM0; 18.
DR   PRIDE; Q8IAM0; -.
DR   EnsemblProtists; CAD51343; CAD51343; PF3D7_0802000.
DR   GeneDB; PF3D7_0802000.1:pep; -.
DR   GeneID; 2655330; -.
DR   KEGG; pfa:PF3D7_0802000; -.
DR   EuPathDB; PlasmoDB:PF3D7_0802000; -.
DR   HOGENOM; HOG000284489; -.
DR   InParanoid; Q8IAM0; -.
DR   KO; K15371; -.
DR   OMA; SVDFFHF; -.
DR   PhylomeDB; Q8IAM0; -.
DR   BioCyc; PLASMO:PF08_0132-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB.
DR   GO; GO:0004352; F:glutamate dehydrogenase (NAD+) activity; ISS:GeneDB.
DR   GO; GO:0006536; P:glutamate metabolic process; ISS:GeneDB.
DR   InterPro; IPR006096; Glu/Leu/Phe/Val_DH_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00208; ELFV_dehydrog; 1.
DR   SMART; SM00839; ELFV_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   4: Predicted;
DR   PRODOM; Q8IAM0.
DR   SWISS-2DPAGE; Q8IAM0.
KW   Oxidoreductase {ECO:0000313|EMBL:CAD51343.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          946..1294
FT                   /note="ELFV_dehydrog"
FT                   /evidence="ECO:0000259|SMART:SM00839"
FT   REGION          768..821
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          834..865
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1236..1256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        768..782
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        783..811
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1239..1256
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1397 AA;  160425 MW;  C86D83AEE872965A CRC64;
     MDIDRRSALS CSPNNMECGF GSGHFSNNSI TWKEKYEQTK ELLKSYNLFS DHLINYSIDF
     YFNKLGFNKF HFEETSPELI SKVVVCIITA KINEQYSSDK YFPTFEETHD NVIFIITRVF
     ADDNKTRLNY KMEKKIEEKY FNFSDMSKDC YRLKSFRSVH SVFDKEHTYQ EPLRTYILEL
     PTYNDDIIKE NETDLKKLMD VNFYNYIKGT RSEQIYYELN KAVLYDLTGQ FLQTHYYETS
     SSTFTLTIAV KRSNVISSIF SLIGDCLNMH RCFSYSKYVE PLKNGVLLII LNVKVIVNNE
     MEREKQKLDL KDKIYKVVKS LKTLCLFNDS KFIQLSVKRT FTAQESAYLF MIIKFITFFS
     TNTLSSYKNV EHALNLRNYN NNIMDTTTNS SSSPSSVLND VYIIKEKLKS SKYTKEEILR
     CAQSNVRTIK MLFANFEKKL NHQRNKCNQM KYGENNMKNS GDLLKEYSTN NRNVDHPTLS
     SLASSSSSCS SSFSLHSYLS GSYESPYYHH NKDSKDIIDE IEDNHDKKIL QYFYMFEKYA
     LKTNFFLTHK ISLAVAFDGA LLKDSIYEAQ PYSIIMILGL HFVGFHIRFS KISRGGVRIV
     ISNNVNSYMH NSDNLFDEAY NLAYTQNFKN KDIPEGGSKG IILLDADVCN VANTKYIKNL
     SFYSYVNSIL DLLINEDLNE ESASSISVHS TKGANNTTIT FDNVMSSVEN MVDRGGVEGE
     HLNITLPYDA NMACNNNTTN DNLSNMHDTY NLNNSGEATL DHHSVDNRIV SNSSGTNNMN
     AQKGEGEDEK AKDKEMSNNR KNEENERKRC DNVSNSNYNY VNGTTEDAVQ KIMGSKCKGG
     RNNNGEEKDG DMNGHNNNNN DNNNIDDDEH IEECYKGAGC VINGENKTRK MILQEKMNEE
     EDLIFLGPDE NTGSDQLMDW ACIIAKKRKY PYWKTFSTGK LRKNGGVPHD MYGMTTLGIE
     TYISKLCEKL NIKEESISRS LVGGPDGDLG SNAILQSKTK IISIIDGSGI LYDKQGLNKE
     ELIRLAKRRN NKDKSKAITC CTLYDEKYFS KDGFKISIED HNVDIFGNKI RNGLDFRNTF
     FLNPLNKCEL FNPCGGRPHS INIFNVNNII KNGECIYKYI VEGANVFISD DARNILESKN
     VILFKDAATN KGGVISSSLE VLAGLVLDDK QYIDYMCSPD SDILQVDENE INFVHQNQKM
     NHSLSFKRGS INNLEEDEKK DTSNNEKNKN IIKTVNKNDT QDNSHHHNNS NKCNEDQQDV
     SDFYKAYVKE IQKKITHYCE LEFESLWKET RRTKTPISKA INILSNKISE LKKDILSSDT
     LCRDYKLLKK VLERVIPPTL LKIVTFEQIL ERVPYVYIKS LFASSLASNY YYSQQFLNDL
     SAFNFFEYIT KLQSESA
//

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