(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAL6_PLAF7

ID   Q8IAL6_PLAF7            Unreviewed;      1011 AA.
AC   Q8IAL6;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 94.
DE   SubName: Full=Mannose-6-phosphate isomerase, putative {ECO:0000313|EMBL:CAD51347.1};
DE            EC=5.3.1.8 {ECO:0000313|EMBL:CAD51347.1};
GN   ORFNames=PF3D7_0801800 {ECO:0000313|EMBL:CAD51347.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51347.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51347.1; -; Genomic_DNA.
DR   RefSeq; XP_001349498.1; XM_001349462.1.
DR   SMR; Q8IAL6; -.
DR   PRIDE; Q8IAL6; -.
DR   EnsemblProtists; CAD51347; CAD51347; PF3D7_0801800.
DR   GeneDB; PF3D7_0801800.1:pep; -.
DR   GeneID; 2655403; -.
DR   KEGG; pfa:PF3D7_0801800; -.
DR   EuPathDB; PlasmoDB:PF3D7_0801800; -.
DR   HOGENOM; HOG000284490; -.
DR   InParanoid; Q8IAL6; -.
DR   OMA; LWIGNHE; -.
DR   BioCyc; PLASMO:MAL8P1.156-MONOMER; -.
DR   Reactome; R-PFA-446205; Synthesis of GDP-mannose.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004476; F:mannose-6-phosphate isomerase activity; ISM:GeneDB.
DR   GO; GO:0008270; F:zinc ion binding; ISM:GeneDB.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0000032; P:cell wall mannoprotein biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; ISM:GeneDB.
DR   GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR   Gene3D; 2.60.120.10; -; 2.
DR   InterPro; IPR001250; Man6P_Isoase-1.
DR   InterPro; IPR016305; Mannose-6-P_Isomerase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR10309; PTHR10309; 1.
DR   Pfam; PF01238; PMI_typeI; 2.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   4: Predicted;
DR   PRODOM; Q8IAL6.
DR   SWISS-2DPAGE; Q8IAL6.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Isomerase {ECO:0000313|EMBL:CAD51347.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        312..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          59..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          587..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          630..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          233..256
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        59..73
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..104
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..128
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..407
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..441
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        630..650
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..678
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1011 AA;  117662 MW;  FDF26DAC9CAFA6F7 CRC64;
     MSKLCINECI PYVQKYEWGK GKDGLVYEVM KNIVQDNHDI IKKEIDHLEY LREYMDEYDD
     NKDDEEDVEK DDGVNNNDEE KNGKDKKKKN KEKKNNEKDG MDNDINNVSK NIRDNNKSND
     DDNNKNNNNN DKYAELWIGN HDKSPNLVVY KNSLVKIEEF LKIYQKKKNK KSKLMKFFYK
     KVENTKNKYM NKKKFSTKSE DIINKNNNTT KGSTLGGEND LKRYSDIEFA SLNNDSTKEK
     EDMNEQEQLL EEEEVDKNTL FPYLFKMLSI SKPLSIQIHP NEQQTLYLNT MNPLLYKDKI
     FKTEMCVCIN SMTLLCGFMN IFKIAFLIRN IKELNDFFLK RGHQLNQNCD STHQKKADEL
     KFDKKGPNEI VLKDDTNYNK KDNTNGITKD TLDDNKEKKH TDDNISKNNH KNNNNNNNNN
     NNNKSNNNNN NKNNNKNNNI NKENKVESGV ELALITQLLS SSPSASSSCG NINIDSGKDE
     KKDMFYLFDL FYSSKDDHVE EVLSMLSRIY IYIINYALKR GNGLSYDVIS VIDNYAECIQ
     KYVYDENFYS SFYKNEKFLE LNINLGNLIK VEKEKLQNSL SENKFNTDLT ESDMDEVDED
     EKDEKTISDD GVVDSYDVSK KKDKKKVSLE YEKGMDNNND QLDKQKKKTS KGTTTTTTTN
     NNNNNNNNNN NNSCSSSNSS AMIKGIHCEY DKKKTDDDGT KVCEKECATG CSNEYTNVYD
     NLNKQNDPYF ISRKKIKAFY EHMYKFLIYR ILLVENDTLN ECVTSIIEKN EKYQSFINDD
     ETFKKKTEKL YADICKKKNY ENLCKETENF IIHSIFELLK NVSMYYANDG GRIFLFILQL
     INLNDGDVVY IKPGVIHSYI SGHCLECMTN SDLVIRGGLT NKEIDKLNFI KYVNYKNNYP
     IILEKEFINY NIMSYSYHRM KHFKILCITI RPGEVINYVF SEKSFTSCIV LSTNRKVKIK
     GKKNDKKKAS IKNVRKGMIL FIAPSVMVTI SNLYANPEDG NKEFVIYCAT S
//

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