(data stored in ACNUC9543 zone)

SWISSPROT: Q8IAK3_PLAF7

ID   Q8IAK3_PLAF7            Unreviewed;      2980 AA.
AC   Q8IAK3;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 84.
DE   SubName: Full=Erythrocyte membrane protein 1, PfEMP1 {ECO:0000313|EMBL:CAD51361.1};
GN   ORFNames=PF3D7_0800300 {ECO:0000313|EMBL:CAD51361.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51361.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51361.1; -; Genomic_DNA.
DR   RefSeq; XP_001349512.1; XM_001349476.1.
DR   SMR; Q8IAK3; -.
DR   PRIDE; Q8IAK3; -.
DR   EnsemblProtists; CAD51361; CAD51361; PF3D7_0800300.
DR   GeneDB; PF3D7_0800300.1:pep; -.
DR   GeneID; 2655305; -.
DR   KEGG; pfa:PF3D7_0800300; -.
DR   EuPathDB; PlasmoDB:PF3D7_0800300; -.
DR   HOGENOM; HOG000115239; -.
DR   KO; K13850; -.
DR   OMA; CNCKENG; -.
DR   PhylomeDB; Q8IAK3; -.
DR   Reactome; R-PFA-114608; Platelet degranulation.
DR   Reactome; R-PFA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0020002; C:host cell plasma membrane; TAS:GeneDB.
DR   GO; GO:0020030; C:infected host cell surface knob; TAS:GeneDB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0050839; F:cell adhesion molecule binding; TAS:GeneDB.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0020033; P:antigenic variation; TAS:GeneDB.
DR   GO; GO:0098609; P:cell-cell adhesion; TAS:GeneDB.
DR   GO; GO:0020035; P:cytoadherence to microvasculature, mediated by symbiont protein; TAS:GeneDB.
DR   GO; GO:0020013; P:modulation by symbiont of host erythrocyte aggregation; TAS:GeneDB.
DR   GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR   InterPro; IPR041480; CIDR1_gamma.
DR   InterPro; IPR004258; DBL.
DR   InterPro; IPR008602; Duffy-antigen_binding.
DR   InterPro; IPR029211; PfEMP1_ATS.
DR   InterPro; IPR029210; PfEMP1_NTS.
DR   Pfam; PF15445; ATS; 1.
DR   Pfam; PF18562; CIDR1_gamma; 1.
DR   Pfam; PF05424; Duffy_binding; 4.
DR   Pfam; PF15447; NTS; 1.
DR   Pfam; PF03011; PFEMP; 2.
PE   4: Predicted;
DR   PRODOM; Q8IAK3.
DR   SWISS-2DPAGE; Q8IAK3.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN       26     62       NTS. {ECO:0000259|Pfam:PF15447}.
FT   DOMAIN      580    722       PFEMP. {ECO:0000259|Pfam:PF03011}.
FT   DOMAIN     2218   2265       CIDR1_gamma. {ECO:0000259|Pfam:PF18562}.
FT   DOMAIN     2289   2427       PFEMP. {ECO:0000259|Pfam:PF03011}.
FT   DOMAIN     2527   2980       ATS. {ECO:0000259|Pfam:PF15445}.
FT   COILED      386    406       {ECO:0000256|SAM:Coils}.
FT   COILED     1049   1069       {ECO:0000256|SAM:Coils}.
FT   COILED     1621   1652       {ECO:0000256|SAM:Coils}.
FT   COILED     2404   2431       {ECO:0000256|SAM:Coils}.
FT   COILED     2834   2854       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2980 AA;  340614 MW;  52B1B2CD078DB34C CRC64;
     MVPPVRSPRA AGPAPAPASA STTYGSVKDL LEDIGKSIQK QAKDAAEKRS NGELQGDLSK
     ARFKDQKNTT TNPCQLNYRN HSNVRSSFEN DNPCYGREEK RFSDSRSGQC TYNRIKDSKE
     GDNKVGACAP YRRLHICDHN LENINDYKNI NNHTLLVDVC LSAKHEGEMI ANKLKEYDKS
     NYESRICTVL ARSFADIGDI VRGKDLYLGD QQEKLYLENN LKKIFAKIHE NLNDKIKSNY
     NDSEGNYFKL REDWWTANRD QVWKAITCNA PKDANYFEYN SGKFFKFSND QCGHNNGGAP
     PTNLDYVPQF VRWFEEWADD FCRIRKHKLK NIKDVCRNES KPLYCSLNGY DCTKTSWKND
     FESREHYCTP CFSACSLYKI WVANQKKEFE KQKKKYEKEI PKYVSKKVKT NSTINNYYYY
     DFYEKLQKNE YGNIDAFLNL LKEGKYCKEN LPEEEVINFT KHDEKKTFSL SNYCVVCPDC
     GVEYKNGRYT AKDQKYPDCR NEKYDPNNAE TTDITVLYSG DVGDFSEKLQ DFCNDINNGK
     VKNYQIWQCY YENSEINKCQ MTPSSHKVPK HGYIMSFFAF FDLWVKNLLI DTINWKNELT
     NCINNTNVTD CKNDCNTNCK CFENWAKTKE KEWENVKTIY KNENRNTNNY YKKLNDLFKG
     YFFHVMYELN NEEAKWNKLM KNLRTKIDSS RKNAGNEDSE GAIKVLFDHL KDIAERCIDN
     NSIKPCNSHP KPTPNPCGKN NNGGKLVRVK RPAELKQQKA HIQLEKRGGE SNLKGDATRG
     TYNLGCQGDQ LDATFCNIDE KYSNRIPRKS EGPCYGKNPQ RFYTGKDWTH VVQEKTSYKD
     VFLPPRREHM CTSNLENLNL NSKGLSNSSI ASNSLLGDVL LAAKYEADDI VKKNDSDKSS
     ICNAMKYSFA DIGDIIRGKD MWDLDSGSKD MEKHLISIFE KIKENLDVIK YNSKYKDTQK
     FLDLRSDWWE ANRHQVWRAM KCAIENDKDM KCNGIPIEDY IPQRLRWMTE WAEWYCKAQK
     KEYDELVKGC KGCMGNGQGC TKDSSDGECK KCTEACNTYK QKIKTWENQW KKIKGKYEKL
     YEQATKNGET SGTPNEKDKD VVDFLKQLLP RNSAAARNRV IRAAGSSAPG VTALTPITLY
     SSAAGYIHQE LGKTVGCNTQ KEFCKNGSGE KYAFKHPPKE YKDACSCNTR DKKSEAPVTK
     KEEACKIVDG ILKGNDGINE ISGCNPKESY PEWQCDKSKF KNGEEGACMP PRRQKLCVSG
     LTQGGKITTI EDIRTQFITC AAIETHFAWH KYKKDNVNAE RELNSGIIPH EFKRQMYYTF
     GDYRDIFFGT DISTHNHIPE VSQKVITILE KENLTKSEVK QKYKNELLDD WWNEHGKEIW
     DGMVCALCYD TKTKEFKNEV RTQLTGPNSK YQYGTVSFGD KQNTILSKFA ERPPFLRWFI
     EWGEEFCKKR KEQVDQLVNV CKECNVSDSV ISSGNKTCND KEKCDACKKE CTQYENWLQT
     WKGHYNKQKE RYAKVKSTSP YNNDNDVNKS THAYEYLSKK LTNIPCTNGN TTGKCDYKCM
     DQRTSTDGMP ASLEYPPKEI NGKCDCTKAL PPQEPPSTPE SRGRSLNPPP DSPQPPRGPE
     EQEESASYSE EEEEEEEEEE ENDEENDGDE EEVKTEDGGS DDEDEDEEDD EEEEENEVDV
     DEPQQEEVEE PPAKESAPTT QEPAVPEVKK QEVKVCDIVS KILTKDALQD ACKLKYNGKY
     YGWKCISGAT TGGLCIPPRR RKLYVTPLTK WATTAVSSEA TPAPSQSESD KLREAFIQSA
     AIETFFLWHK YKQEKKPPSE QNAGAALVLL QGVTPQEDPQ NKLKSGTIPE EFKRQMFYTL
     GDYADIFFGK NDILIGKTGT GSAKDEMADK ESKIKEAIKK FFQNGDSQPL SGKPVTQSSD
     KRTALWGDFA QDIWHGMICA LTYTDSGEKG ELPKEDDKVK DKLWDDTKKQ PKKEEYQYDK
     VKLDENSGDG PKTSQPPSAP SDTPTTLDSF IKRPPYFRYL EEWGQNFCKK RTEMLGKIKG
     DCRVEDGSKN CSGYGEDCDD QLGEDPSTVP SLKCQSCGEE CRKYKKWIER KKDEFTKHSN
     AYGDQKAKCQ AKSGGGGNGF CGTLERCSKA AEFLKTLGSC KTNNGNESVE ANKTIFDNIG
     ETFKPATNCK PCSQFKIYCK NCKSSGDDTN VGCNCKENGN GYITSDHIKN EDNFTDPVDM
     LVSDDNTNGN KFADLQACGG AGIFKGIRKD QWKCRNVCGY VVCKSEKGNG ETVRGEKNDV
     KHIITIRALV THWVEYFLDD YNKINKKLNR CMKDGEGYQC IKDCVEKWIQ NKREEWKKIK
     ELYLQEYKNN NQPDYLVKII LEELHPQTQL NEAIKPCKTF DDFKSFCGLN GAESSKKSKN
     SNDNDLVLCM LNKLEKKIDE CKQKHQASGK NTAQCQEYPP LPDEEYENEE ENDKKVEPPT
     FCEIKDTPEP ADEDACKAAP KETAPSSEEN QPETPVIKPE EEAPAPEEPP PAPPPLAPSD
     ESILHTTIPF GVALALGSIA FLFLKKKTKS TIDLLRVINI PKSDYNIPTK LSPNRYIPYT
     SGKYRGKRYI YIEGDSGTDS GYTDHYSDIT SSSESEYEEL DINDIYVPGT PKYKTLIEVV
     LEPSGNNTTA SGKNTPSDTQ NDIQNDGIPS SKITDNEWNT LKDEFISQYL QSEQPKDVPN
     DYKSGDIPFN TQPNTLYFDK PEEKPFITSI HDRNLYSGEE HSYNVNMVNS MDDIPINSHN
     NVYSGIDLIN DTLSGNQHID IYDELLKRKE NELFGTNHVK QTSIHSVAKP ISDDPIHNQL
     ELFHKWLDRH RDMCEKWENH HERLAKLKEE WENDTSTSGN THPSDSNKTL NTDVSIQIDM
     DNPKTTNEFT YVDSNPNQVD DTYVDSNPDN SSMDTILEDL EKYKEPYYDV QDDIYYDVHD
     HDTSTVDTNA MDVPSKVQIE MDINTKLVKE KYPIGDVWDI
//

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