(data stored in SCRATCH zone)

SWISSPROT: Q8IAK2_PLAF7

ID   Q8IAK2_PLAF7            Unreviewed;      2858 AA.
AC   Q8IAK2;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 93.
DE   SubName: Full=Erythrocyte membrane protein 1, PfEMP1 {ECO:0000313|EMBL:CAD51362.1};
GN   ORFNames=PF3D7_0800200 {ECO:0000313|EMBL:CAD51362.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51362.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51362.1; -; Genomic_DNA.
DR   RefSeq; XP_001349513.1; XM_001349477.1.
DR   SMR; Q8IAK2; -.
DR   SwissPalm; Q8IAK2; -.
DR   PRIDE; Q8IAK2; -.
DR   EnsemblProtists; CAD51362; CAD51362; PF3D7_0800200.
DR   GeneDB; PF3D7_0800200.1:pep; -.
DR   GeneID; 2655302; -.
DR   KEGG; pfa:PF3D7_0800200; -.
DR   EuPathDB; PlasmoDB:PF3D7_0800200; -.
DR   HOGENOM; HOG000115239; -.
DR   KO; K13850; -.
DR   OMA; QECENHC; -.
DR   PhylomeDB; Q8IAK2; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0020002; C:host cell plasma membrane; TAS:GeneDB.
DR   GO; GO:0020030; C:infected host cell surface knob; TAS:GeneDB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0050839; F:cell adhesion molecule binding; TAS:GeneDB.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0020033; P:antigenic variation; TAS:GeneDB.
DR   GO; GO:0098609; P:cell-cell adhesion; TAS:GeneDB.
DR   GO; GO:0020035; P:cytoadherence to microvasculature, mediated by symbiont protein; TAS:GeneDB.
DR   GO; GO:0020013; P:modulation by symbiont of host erythrocyte aggregation; TAS:GeneDB.
DR   GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR   Gene3D; 1.20.1310.20; -; 5.
DR   InterPro; IPR041480; CIDR1_gamma.
DR   InterPro; IPR004258; DBL.
DR   InterPro; IPR042202; Duffy-ag-bd_sf.
DR   InterPro; IPR008602; Duffy-antigen-binding.
DR   InterPro; IPR029211; PfEMP1_ATS.
DR   InterPro; IPR029210; PfEMP1_NTS.
DR   Pfam; PF15445; ATS; 1.
DR   Pfam; PF18562; CIDR1_gamma; 1.
DR   Pfam; PF05424; Duffy_binding; 5.
DR   Pfam; PF15447; NTS; 1.
DR   Pfam; PF03011; PFEMP; 1.
PE   4: Predicted;
DR   PRODOM; Q8IAK2.
DR   SWISS-2DPAGE; Q8IAK2.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          21..56
FT                   /note="NTS"
FT                   /evidence="ECO:0000259|Pfam:PF15447"
FT   DOMAIN          502..551
FT                   /note="CIDR1_gamma"
FT                   /evidence="ECO:0000259|Pfam:PF18562"
FT   DOMAIN          566..709
FT                   /note="PFEMP"
FT                   /evidence="ECO:0000259|Pfam:PF03011"
FT   DOMAIN          2448..2858
FT                   /note="ATS"
FT                   /evidence="ECO:0000259|Pfam:PF15445"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          720..758
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          776..797
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2387..2441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          375..395
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2132..2152
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        2396..2419
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2420..2437
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2858 AA;  330697 MW;  0170B3E07C7200B0 CRC64;
     MGSQGSKPVD TSDVKNESHN SARNVFENIA EIIYNRVKED AEKRGKSLKG DYKRAKFHQP
     LLEAAKYVWY APSNPCNFDF RFDTNAPDKG SYDRDPCHLR DTNRFSDKGD AICTNNKINC
     NNGGCGACAP YRRIQLCDYN LEYINEYNIN STHDLLGNLL VMAKREGDSI VNSHGHTGKG
     IYKSGICTSL ARSFADIGDI IRGKDLFLGH NHKKKPLLDN LEKIFNRFQK IYEDINNLPI
     DDIREYWWAL NRNDVWEALT CSAPYYADYF KKKSGNTYNF TTEGYCGRNE GAPPTNLDYV
     PQFLRWFDEW AEEFCRIKNI KIGNIKKSCT GESNNKHCSR EGYDCNKTNL RLNEIFMDLE
     CPRCADDCKS YETWVENKKK EFNKQKEKYK EEINESKPGV NSEHGKYNKA FYDKLRTIYR
     TNDKFFEILN KGQICENVDE KNKIDFNDLV KTFSRSEYCK SCPMLGVTCK GEQCNSLDDI
     TCTNDKGGPN KVTDKNNNTF VIDILLNDNK KKVLSNDLND YKECDLFKRL RRQNWNCKYK
     CNLHVCELNN FNNEIDDERV ISIKVFIKRW LESFLKDYNK LKENLNPCIN NENQLPCIKD
     CLENCDCVEK WIKKKGEEWK KIKERYLKDY KIEDNNSSNS LNKFLQQNQF HSDVVKAIKP
     FENLRAFEDS SGCTGTVPSG IEECKSNDVI KILLSKLKEK IELCKKNDVK KNKSNNCVTL
     LKPLNDEEDD EEQDDEPPAP KPLPTPNPCV NGGDDTSGAQ ITSVTEIAEG MHMGAQKQML
     ERSGDKSGKG TENGESVLKG DIKKAKFKNG ASPSSLEDVC GITDQHTKDS RRRRRLRRLR
     LLVLRFRRRL RRGHRDYKGP CTGKDGHKKM FQVEKGWENG SKIGTENDVF LPPRREHFCT
     SNVEHLYRSA SGLQGTTASH SLLGDVLLAA NKEAGFIKER YKTQKTSEGF KDEATVCRAI
     KYSFADIADI IKGTDLWKAN SGKKNTQDKL VKIFQKIKDN LPVNIKGKYN EDEKHLELRK
     DWWFANRDKV WEAMKCEQNG ITCSGPTPLD DYIPQRLRWM TEWAEWYCKA QKEAYDKLKV
     CEKCMDNGKC TQGNGECAKC KTACENYKKF INTWQPQWKQ MEQKYESLYK EAQENGNSSH
     KSTTEQDKYM VEFLSQLQKA NNGDKTGDDK VYSTAAGYVH QEATMNCEKQ TQFCKNKNGV
     KAANDAEDVN YTFKDTPNGY DVVCKCKDRP EQQIKKKEVE DACKIAQDIF KGKDENTTVG
     LCKKKDFGRT PYPDWKCEKN SKLVTGNGEC MPPRRQKLCL YFLAHKIETP NLNTQEDLRK
     AFIKCAAAET FFSWYYFKKI NDKLNKLDEK LKEGEIPPQF LRSMFYTFGD YKDICLDTDI
     SLKTENGDIT KAKSNIDRII PKKSAKNPDE ERKIWWDGIK EDVWEGMLCG LSHAVSNNDK
     ATVQKTLTTK TIYDYDTVTF DGTTKLEDFS KRPQFLRWMT EWGEEFCKKR KEQLENLKDK
     CPDYTCSFDT KKQECENHCK VYEEWLKGWK DQYKKQSEKF TTDKEKPEYK DDPDVASSEN
     AHKYLSKKLK QIFHNGSTTE KCDYTCMEYA SRQPQTSACS QQQQQQNKSS TQNHFPEAFD
     YPPKEIGDRC TCPKLPEPKY CVDKTAYDIR KESGKKSDNS LKGNGNTYNN NCNNSMREEY
     ANQNGETCKF NETFWSKKKP SIEECDINAK ERFQIQKYWD CNGKTPDGKN TFCIPPRRKD
     MCLKQLEEIN SADVNNSKKL LQKIQDVAKK EGDDIIKKLL PKYPCNEDVI CKAMKYSFAD
     LADIVRGIDK YKGPNGTNVL EKELKSVFET IYTKWKSENT NNKSKYTDVA SFRSAWWDAN
     RKDIWNAMTC NAPYDAKIYI TKEGGYISPL TFTKNKCGHN DDPPDYDYIP QPFRWLSEWS
     ETYCLAQKDL LETMKNCENC MKKNKNADCE QTQYGACRDC KRKCEEYKKF IEIWKKQFET
     QNKAYQEIYR NATTTNRDNN NIVDENTKNF VKKLQENCRT DRNESLDTAD KYLENASVCR
     RFKFGNKDSR HLNYAFHTDP PSYEEHCKCA KDFDPLDECP VDNNECKKYG IGSCPKKNFH
     KKLEEWTNYV LNNKSNKNKS AIVPPRRRQL CLQNLTRNLS RLNKEKSFKE GILISAASEA
     KMLTEQYREN PAKALQAIKY SFADIGNIIK GDDIIGNVIS VQLNKLINGN KKINTSTLWW
     EANKEKIWNA MMCYYTGDEK TATSCPSHGN IDKEDQFLLW FQEWGENFCA RQKELYEHVQ
     AECSHVICVN GTGNIDSKCT EACKNYSNFI SETKNVYQSL KKQYNDNHNS IKVGGKEVHH
     YMKEKCKDKC ECLSEKFNSD NNWEKPYDTF DDTVLKNKCQ CKKPDSPILP VEPSVPAETE
     KEKKKDSPLK PHTEPKPAPP KKPEVPPPPP VQPPPANQPF NRDILEKTIP FGIALALGSI
     AFLFIKKKPK SPVDLIRVLD IHKGDYGMPT LKSKNRYIPY ASDTYKGKTY IYMEGDSDSG
     HYYEDTTDIT SSESEYEEMD INDIYVPDSP KYKTLIEVVL EPSKRDTPSS DAPMNKFTDD
     EWNQLKQDFI SGILENEQKD LPKNNISGNT PMNTQPNTLY FNKPEEKPFI TSIHDRDLYS
     GEEINYNINM STNSMDDTSY VSNNVYSGID LINDTLSGNQ HIDIYDEVLK RKENELFGTN
     YKKNTSNNNV AKLTNSDPIM NQLDLLHKWL DRHRDMCEKW KSKEDILHKL NEQWNKDNDG
     GNVPIDNRSL NTDVWIEIDM DDPKGKKEFS NMDTILDDIE DDIYYDVNDD ENPSVDNIPM
     DHNKVDVPKK VHVEMKILNN TSNGSLEPEF PISDVWNI
//

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