(data stored in ACNUC1104 zone)

SWISSPROT: Q8CJS4_STRCO

ID   Q8CJS4_STRCO            Unreviewed;       200 AA.
AC   Q8CJS4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 119.
DE   SubName: Full=Putative tetR-family transcriptional regulator {ECO:0000313|EMBL:CAD55220.1};
DE   SubName: Full=TetR family transcriptional regulator {ECO:0000313|EMBL:TYP03660.1};
GN   OrderedLocusNames=SCO4940 {ECO:0000313|EMBL:CAD55220.1};
GN   ORFNames=FHV98_12721 {ECO:0000313|EMBL:TYP03660.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226 {ECO:0000313|Proteomes:UP000001973};
RN   [1] {ECO:0000313|EMBL:CAD55220.1, ECO:0000313|Proteomes:UP000001973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A3 {ECO:0000313|EMBL:CAD55220.1}, and ATCC BAA-471 / A3(2) /
RC   M145 {ECO:0000313|Proteomes:UP000001973};
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA   Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2] {ECO:0000213|PDB:2HYJ}
RP   X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) IN COMPLEX WITH CALCIUM.
RA   Zhang R., Xu X., Zheng H., Savchenko A., Edwards A., Joachimiak A.;
RT   "The crystal structure of a tetR-family transcriptional regulator from
RT   Streptomyces coelicolor.";
RL   Submitted (AUG-2006) to the PDB data bank.
RN   [3] {ECO:0000313|EMBL:TYP03660.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ICSSB 1010 {ECO:0000313|EMBL:TYP03660.1};
RA   Yuzawa S.;
RT   "Genome sequencing of Streptomyces strains engineered using actinophage
RT   integration system.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AL939122; CAD55220.1; -; Genomic_DNA.
DR   EMBL; VNID01000027; TYP03660.1; -; Genomic_DNA.
DR   RefSeq; NP_733652.1; NC_003888.3.
DR   RefSeq; WP_003974034.1; NC_003888.3.
DR   PDB; 2HYJ; X-ray; 2.19 A; A=1-200.
DR   PDBsum; 2HYJ; -.
DR   STRING; 100226.SCO4940; -.
DR   EnsemblBacteria; CAD55220; CAD55220; CAD55220.
DR   GeneID; 1100381; -.
DR   KEGG; sco:SCO4940; -.
DR   PATRIC; fig|100226.15.peg.5020; -.
DR   eggNOG; COG1309; LUCA.
DR   HOGENOM; HOG000264381; -.
DR   InParanoid; Q8CJS4; -.
DR   OMA; GCLFTTA; -.
DR   PhylomeDB; Q8CJS4; -.
DR   EvolutionaryTrace; Q8CJS4; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q8CJS4.
DR   SWISS-2DPAGE; Q8CJS4.
KW   3D-structure {ECO:0000213|PDB:2HYJ}; Calcium {ECO:0000213|PDB:2HYJ};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335,
KW   ECO:0000256|SAAS:SAAS00132209}; Metal-binding {ECO:0000213|PDB:2HYJ};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW   Transcription {ECO:0000256|SAAS:SAAS00131596};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00132066}.
FT   DOMAIN          11..71
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50977"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
FT   METAL           138
FT                   /note="Calcium"
FT                   /evidence="ECO:0000213|PDB:2HYJ"
SQ   SEQUENCE   200 AA;  21737 MW;  7B033B4B22F71423 CRC64;
     MSPRRSAAEA QATRGRILGR AAEIASEEGL DGITIGRLAE ELEMSKSGVH KHFGTKETLQ
     ISTLDKAFVD FWHRVVEPAL AEPPGLRRLR AVCANSVGYL EEPLLPGGCL LTAALSEYDG
     RPGRVRDAVA EVWSRWREQL RADLTAAVDK GELPAGFDVE QALFEIVAAG LALNAAMQLQ
     HDRTAADRAR RAIERALAQS
//

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