(data stored in ACNUC1104 zone)

SWISSPROT: Q7WAB8_BORPA

ID   Q7WAB8_BORPA            Unreviewed;       584 AA.
AC   Q7WAB8;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   08-MAY-2019, entry version 107.
DE   SubName: Full=Tw-component sensor kinase {ECO:0000313|EMBL:CAE36763.1};
GN   OrderedLocusNames=BPP1461 {ECO:0000313|EMBL:CAE36763.1};
OS   Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257311 {ECO:0000313|Proteomes:UP000001421};
RN   [1] {ECO:0000313|Proteomes:UP000001421}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12822 / ATCC BAA-587 / NCTC 13253
RC   {ECO:0000313|Proteomes:UP000001421};
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.,
RA   Harris D.E., Holden M.T., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.M., Temple L., James K., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J.,
RA   Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C.,
RA   Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K.,
RA   Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K.,
RA   Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01118672};
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DR   EMBL; BX640427; CAE36763.1; -; Genomic_DNA.
DR   RefSeq; WP_010928048.1; NC_002928.3.
DR   EnsemblBacteria; CAE36763; CAE36763; BPP1461.
DR   KEGG; bpa:BPP1461; -.
DR   HOGENOM; HOG000262135; -.
DR   OMA; PGRHEQH; -.
DR   BioCyc; BPAR257311:G1GSY-1501-MONOMER; -.
DR   Proteomes; UP000001421; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013656; PAS_4.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF08448; PAS_4; 1.
DR   Pfam; PF13188; PAS_8; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55785; SSF55785; 2.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
DR   PRODOM; Q7WAB8.
DR   SWISS-2DPAGE; Q7WAB8.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001421};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:CAE36763.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     24     47       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     67     87       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      102    174       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN      178    230       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      358    569       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   584 AA;  66103 MW;  40DD3E19646B610A CRC64;
     MSSPPKSNIP MSFRDHARAR RRGVYWLTPA LVLVLYICVM GVFFWLQRIH DDSVMFVTID
     QELRQQRLIW VVLALSCVIV ISLLMLWRYT RFRSEAEAAL IAETGFRRAM ENSMSTGMRV
     LDMEGRIAYV NPAFCRMIGW NEADLIGRSP PFPYWVPGRH EQHQHTLEVL TSGKTPSSGL
     EVEAQRRDGS RFTARMYVSP LLDPNGDQIG WMTSMTDITE PKRIREALTA AHERFMTVLE
     GLDDAISVTA DTHDGLELLF ANRTYRRVFG AQTGGHNELL AGRRGRFTDE SVEVLAPSVQ
     RWFEVHHRML AWTDGRRVRM QVARDITERR VHEEASRVQQ EKIQLTSRLT TMGEMASSLA
     HELNQPLTAI ANYSMGAVAL VKAGHTSPNM LLPALEKAAS QAERAGKIIS RIREFVKRSE
     PRRQRVAISR IVDNAIGFAE IDARKRRIRI ERFVPSNAPD VLADPILIEQ VLLNLLKNGL
     EAMEKSESDE LKVAVIPHEQ HIEVAVVDRG HGLPEPERLF EPFFSTKSQG LGMGLNICRT
     IIESHHGRLW ADPNPAGGTI FRFTLPCATP QSQAQNDQSE ELHA
//

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