(data stored in ACNUC1104 zone)

SWISSPROT: Q7WA53_BORPA

ID   Q7WA53_BORPA            Unreviewed;       444 AA.
AC   Q7WA53;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   08-MAY-2019, entry version 110.
DE   RecName: Full=Zinc metalloprotease {ECO:0000256|RuleBase:RU362031};
DE            EC=3.4.24.- {ECO:0000256|RuleBase:RU362031};
GN   OrderedLocusNames=BPP1534 {ECO:0000313|EMBL:CAE36836.1};
OS   Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257311 {ECO:0000313|Proteomes:UP000001421};
RN   [1] {ECO:0000313|Proteomes:UP000001421}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12822 / ATCC BAA-587 / NCTC 13253
RC   {ECO:0000313|Proteomes:UP000001421};
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.,
RA   Harris D.E., Holden M.T., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.M., Temple L., James K., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J.,
RA   Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C.,
RA   Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K.,
RA   Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K.,
RA   Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU362031,
CC         ECO:0000256|SAAS:SAAS00913187};
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|RuleBase:RU362031, ECO:0000256|SAAS:SAAS00563376}.
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DR   EMBL; BX640427; CAE36836.1; -; Genomic_DNA.
DR   RefSeq; WP_003811786.1; NC_002928.3.
DR   EnsemblBacteria; CAE36836; CAE36836; BPP1534.
DR   KEGG; bpa:BPP1534; -.
DR   HOGENOM; HOG000006281; -.
DR   KO; K11749; -.
DR   OMA; MFLGLFN; -.
DR   BioCyc; BPAR257311:G1GSY-1574-MONOMER; -.
DR   Proteomes; UP000001421; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   Pfam; PF17820; PDZ_6; 2.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 2.
DR   TIGRFAMs; TIGR00054; TIGR00054; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q7WA53.
DR   SWISS-2DPAGE; Q7WA53.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00462286};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001421};
KW   Hydrolase {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069908};
KW   Membrane {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069850};
KW   Metal-binding {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00913207};
KW   Metalloprotease {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069945};
KW   Protease {ECO:0000256|SAAS:SAAS00069928};
KW   Transmembrane {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069900};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069864};
KW   Zinc {ECO:0000256|RuleBase:RU362031, ECO:0000256|SAAS:SAAS00090197}.
FT   TRANSMEM     95    116       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM    371    392       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM    418    436       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   DOMAIN      112    184       PDZ. {ECO:0000259|SMART:SM00228}.
FT   DOMAIN      209    276       PDZ. {ECO:0000259|SMART:SM00228}.
SQ   SEQUENCE   444 AA;  46769 MW;  BA917BF6F406AE79 CRC64;
     MLFTLLAFVV ALGTLITFHE LGHYWIARLC GVRVLRFSVG FGRVLARRTD RHGTEWAISA
     IPLGGYVKMQ DDPPAGASAA EAARSFNAQP VGRRIAIVAA GPLFNLFLAV VLYAGLNLAG
     TEVPAPVVGQ PAAGTPAAQA GLMAGDRIEA VQGRAVDSWN DARWRLLDVL SSQGEAQLEV
     RGPGGAARGL VLQVPGGNRL DPADGDPLAE TGLRLAQPKP VVREVIAGGA GEQAGLRGGD
     LIVAAGQAAD LDAGALVALI QRHAGQPLAL TVQRGADRLT LTVVPRAESV QGQEVGRIGV
     QLGGDIPMVT VRYGVIDSVW RGAQRTWDTA WLSLRMMGRM VLGEVSWRNI SGPVTIADYA
     GQTARIGLEA YIAYLALISI SLGVLNLLPI PMLDGGHLLY YLVEIVKGSP VSDRWIDIGQ
     RAGIGLLAGL MGLALFNDFA RLFT
//

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