(data stored in ACNUC9435 zone)

SWISSPROT: YOPE_YERPS

ID   YOPE_YERPS              Reviewed;         219 AA.
AC   P08008; Q663N9;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 2.
DT   11-DEC-2019, entry version 124.
DE   RecName: Full=Outer membrane virulence protein YopE;
GN   Name=yopE; Synonyms=yop25; OrderedLocusNames=pYV0025;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OG   Plasmid pIB1, and Plasmid pYV.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=YPIII / Serotype O:3; PLASMID=pIB1;
RX   PubMed=2835586; DOI=10.1111/j.1365-2958.1988.tb00013.x;
RA   Forsberg A., Wolf-Watz H.;
RT   "The virulence protein Yop5 of Yersinia pseudotuberculosis is regulated at
RT   transcriptional level by plasmid-plB1-encoded trans-acting elements
RT   controlled by temperature and calcium.";
RL   Mol. Microbiol. 2:121-133(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953; PLASMID=pYV;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Essential virulence determinant; cytotoxic effector, involved
CC       in resistance to phagocytosis.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- INDUCTION: At 37 degrees Celsius in the absence of calcium.
CC   -!- MISCELLANEOUS: N-terminal is important for export, C-terminal is
CC       indispensable for virulence.
CC   -!- SIMILARITY: Belongs to the YopE family. {ECO:0000305}.
DR   EMBL; Y00543; CAA68609.1; -; Genomic_DNA.
DR   EMBL; BX936399; CAF25368.1; -; Genomic_DNA.
DR   PIR; S03766; S03766.
DR   RefSeq; WP_002229754.1; NZ_CP009711.1.
DR   PDB; 1L2W; X-ray; 2.00 A; I/J/K/L=17-85.
DR   PDBsum; 1L2W; -.
DR   SMR; P08008; -.
DR   EnsemblBacteria; CAF25368; CAF25368; pYV0025.
DR   KEGG; ypo:BZ17_4209; -.
DR   KEGG; yps:pYV0025; -.
DR   PATRIC; fig|273123.14.peg.4442; -.
DR   HOGENOM; HOG000219628; -.
DR   KO; K23473; -.
DR   OMA; KSEQYAN; -.
DR   EvolutionaryTrace; P08008; -.
DR   Proteomes; UP000001011; Plasmid pYV.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0050765; P:negative regulation of phagocytosis; IEA:InterPro.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00219; ToxGAP; 1.
DR   DisProt; DP01144; -.
DR   Gene3D; 1.20.120.260; -; 1.
DR   InterPro; IPR003537; Vir_YopE.
DR   InterPro; IPR014773; YopE_GAP_dom.
DR   InterPro; IPR037168; YopE_GAP_dom_sf.
DR   InterPro; IPR015110; YopE_N_dom.
DR   Pfam; PF03545; YopE; 1.
DR   Pfam; PF09020; YopE_N; 1.
DR   PRINTS; PR01372; YERSINIAYOPE.
DR   SUPFAM; SSF47233; SSF47233; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P08008.
DR   SWISS-2DPAGE; P08008.
KW   3D-structure; Cell outer membrane; Membrane; Plasmid; Virulence.
FT   CHAIN           1..219
FT                   /note="Outer membrane virulence protein YopE"
FT                   /id="PRO_0000066367"
FT   CONFLICT        134
FT                   /note="D -> A (in Ref. 1; CAA68609)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        187
FT                   /note="A -> V (in Ref. 1; CAA68609)"
FT                   /evidence="ECO:0000305"
FT   STRAND          29..34
FT                   /evidence="ECO:0000244|PDB:1L2W"
FT   HELIX           38..44
FT                   /evidence="ECO:0000244|PDB:1L2W"
FT   STRAND          60..62
FT                   /evidence="ECO:0000244|PDB:1L2W"
FT   HELIX           68..77
FT                   /evidence="ECO:0000244|PDB:1L2W"
SQ   SEQUENCE   219 AA;  22987 MW;  8E07FF064947B60D CRC64;
     MKISSFISTS LPLPTSVSGS SSVGEMSGRS VSQQTSDQYA NNLAGRTESP QGSSLASRII
     ERLSSVAHSV IGFIQRMFSE GSHKPVVTPA PTPAQMPSPT SFSDSIKQLA AETLPKYMQQ
     LNSLDAEMLQ KNHDQFATGS GPLRGSITQC QGLMQFCGGE LQAEASAILN TPVCGIPFSQ
     WGTIGGAASA YVASGVDLTQ AANEIKGLAQ QMQKLLSLM
//

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