(data stored in ACNUC9435 zone)

SWISSPROT: YSCR_YERPS

ID   YSCR_YERPS              Reviewed;         217 AA.
AC   P69981; P40297; P42714; Q663J5;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   11-DEC-2019, entry version 78.
DE   RecName: Full=Yop proteins translocation protein R;
GN   Name=yscR; OrderedLocusNames=pYV0071;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OG   Plasmid pIB1, and Plasmid pYV.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=YPIII / Serotype O:3; PLASMID=pIB1;
RX   PubMed=8169210; DOI=10.1128/jb.176.9.2619-2626.1994;
RA   Bergman T., Erickson K., Galyov E., Persson C., Wolf-Watz H.;
RT   "The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved
RT   in Yop secretion and shows high homology to the spa gene clusters of
RT   Shigella flexneri and Salmonella typhimurium.";
RL   J. Bacteriol. 176:2619-2626(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953; PLASMID=pYV;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Component of the yop secretion machinery. May have a role in
CC       the negative pathway regulation of yop expression controlled by
CC       calcium.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FliP/MopC/SpaP family. {ECO:0000305}.
DR   EMBL; L25667; AAA27678.1; -; Genomic_DNA.
DR   EMBL; BX936399; CAF25414.1; -; Genomic_DNA.
DR   RefSeq; WP_002212947.1; NZ_CP009711.1.
DR   EnsemblBacteria; CAF25414; CAF25414; pYV0071.
DR   GeneID; 39573268; -.
DR   KEGG; ypo:BZ17_4263; -.
DR   KEGG; yps:pYV0071; -.
DR   PATRIC; fig|273123.14.peg.4499; -.
DR   HOGENOM; HOG000253557; -.
DR   KO; K03226; -.
DR   OMA; MEPVFTE; -.
DR   Proteomes; UP000001011; Plasmid pYV.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   InterPro; IPR005838; T3SS_IM_P.
DR   InterPro; IPR005773; YopR.
DR   PANTHER; PTHR30587; PTHR30587; 1.
DR   Pfam; PF00813; FliP; 1.
DR   PRINTS; PR01302; TYPE3IMPPROT.
DR   TIGRFAMs; TIGR01102; yscR; 1.
DR   PROSITE; PS01060; FLIP_1; 1.
DR   PROSITE; PS01061; FLIP_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; P69981.
DR   SWISS-2DPAGE; P69981.
KW   Cell membrane; Membrane; Plasmid; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   CHAIN           1..217
FT                   /note="Yop proteins translocation protein R"
FT                   /id="PRO_0000192001"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   217 AA;  24427 MW;  088CDA8F81959421 CRC64;
     MIQLPDEINL IIVLSLLTLL PLISVMATSF VKFAVVFSLL RNALGVQQIP PNMAMYGLAI
     ILSLYVMAPV GFATQDYLQA NEVSLTNIES VEKFFDEGLA PYRMFLKQHI QAQEYSFFVD
     STKQLWPKQY ADRLESDSLF ILLPAFTVSE LTRAFEIGFL IYLPFIVIDL VISNILLAMG
     MMMVSPMTIS LPFKLLLFVL LDGWTRLTHG LVISYGG
//

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