(data stored in ACNUC8465 zone)

SWISSPROT: IML1_CANGA

ID   IML1_CANGA              Reviewed;        1804 AA.
AC   Q6FK84;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   08-MAY-2019, entry version 84.
DE   RecName: Full=Vacuolar membrane-associated protein IML1;
GN   Name=IML1; OrderedLocusNames=CAGL0M00352g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
DR   EMBL; CR380959; CAG62336.1; -; Genomic_DNA.
DR   RefSeq; XP_449360.1; XM_449360.1.
DR   SMR; Q6FK84; -.
DR   STRING; 5478.XP_449360.1; -.
DR   PRIDE; Q6FK84; -.
DR   EnsemblFungi; CAG62336; CAG62336; CAGL0M00352g.
DR   GeneID; 2891143; -.
DR   KEGG; cgr:CAGL0M00352g; -.
DR   CGD; CAL0137411; CAGL0M00352g.
DR   EuPathDB; FungiDB:CAGL0M00352g; -.
DR   eggNOG; KOG3572; Eukaryota.
DR   eggNOG; ENOG410XQVG; LUCA.
DR   HOGENOM; HOG000093241; -.
DR   InParanoid; Q6FK84; -.
DR   KO; K20404; -.
DR   OMA; YDLQMRS; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IEA:EnsemblFungi.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:EnsemblFungi.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:EnsemblFungi.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IEA:EnsemblFungi.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:EnsemblFungi.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblFungi.
DR   GO; GO:2000785; P:regulation of autophagosome assembly; IEA:EnsemblFungi.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FK84.
DR   SWISS-2DPAGE; Q6FK84.
KW   Complete proteome; Membrane; Reference proteome; Vacuole.
FT   CHAIN         1   1804       Vacuolar membrane-associated protein
FT                                IML1.
FT                                /FTId=PRO_0000301767.
FT   DOMAIN     1414   1489       DEP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00066}.
SQ   SEQUENCE   1804 AA;  207409 MW;  1367FEE9FCEDCDEB CRC64;
     MFSALRSKNQ SNKRSNDDSI NSRKDVNELS LGAGGTSTST NTNHNDSPSI KNKNKNKNKN
     KTENENIYKL TISSGRSRGT ASNTTNANTL VLNAGVAIVG KAPIASSQNE IQTISGQSLQ
     SGIDTNLMTA GFGRSAGIDS TTTVSHDANS VKSRLQRLPT ITTSYKEINN GNKPVQVEPQ
     DDSHYTSSLL VDTDPRSNNQ PQSISSNAVA NVEINRTLQL DLVYHESRVS EKLVMLDLKK
     LPHIKEGQLC ELRTYRKRKS TSARSNKNSR DKKLYFIAHD FDEETRKRCH KFGNISVALG
     QLQLLLDLPP RSRVWIKPKR KEDTAADLIE LHIKDILVNR GDMWCMSSEL VDTCVFTGQR
     IMFLDSIRTT VNGIYKNGKK VLSGYINDNT KIVFRSESSR LLFIIQITNE MWSFDESGEQ
     MFQKMINSFF PKIFNKWKDI ETHHSITIAF AISMDMSTSS YKDLKPGQRI KNTTDYYRIV
     VDQVSVIYWV EIMESLRKEF MEITRELLSR KSDDKKDNEL SVIKGRFAPV IKSNILELIN
     FAATTIVDPF RQLDLRHTST HVMIISPGKG LYDVDYDLLQ LSCKKLLSLE LTMDLICLSN
     PPLHVVPLFR YIDYENKLHH CIPPWLNIFF WNDKTKDTNK WTPRCQIYDL QMMGLTDTEL
     VQELELDYLN PSDDINDLQT FLKDYDRDIF LPISTANFKA ENISSDPDEE DLKELKKIND
     KTTTIHKSST SRNTLTKSQR TNSEENNSIR SRKGDTIIKD PQFVGKISNS SRNNPPYDLS
     DKSTFEKQFK PKTTFHPSAM IKKTPENMKK LTNPVFQQQY FDIQTDNGLT GNSKNLLIKN
     TKYLTPIIDE PQTPLVTGNL YRTRFESQSN DNELNENSKL PERGGGTDER RNVSAADTLK
     DVTKKSSIKD FTQRIFTKFL ATTKQSNFNS DGINSSAITE DAVLISDDTD GKTNNNNDFA
     VYPSSVADGD VSGDNQHRLN NKDSFTSILK PIPRPQLGVK IFKSDINNLS SNENVNSETK
     QNLLGTRNTI NRKQFTASPH FTSSTKNSVS NHSRFIKFDS MDDWIEILED SIPSYSFLGD
     DLLPTRWRDV WPKNVFRKYS KWKSFTSPAE LPITLKRFPS KYELENNFML RNHSVTQNWE
     QEQYKLTTKD LLRNMIYLRL LVGFQICTSS TIEEVESARK GDRDVFAIHK YLRGDLTGTF
     KIYMLMGSEI HRLHYDNSGT INVERYIEKS ERNVFDQVPS YTSFVKTRYD SNYRKTDVDP
     IHTKRSEFNW NLLDQLLAGY SDPYLYDEWH GFRSKYVILP AEIPSNTFSM VVNGKNETLT
     TEEIRVEGLR KLIASITRLK LLSVEESKIQ KDRKTEIQPE VIFYTGSLFD FLNEQQAQLD
     SSTLNFKDSI FGDVTKKLNK NIDLKNLAQE LQMGENKLNL VTRKWHWKRH ANCFVGSEMV
     NWLIRNFSDI DTRSTAISYG QKLMNDGLFI HVLDKHSFLD GNYFYQISPE FIINMNTVER
     TNSKNSNTSD NNTLKKTTSR NSTESNLTPL SMRNKVSTMD DDSTQLANTT SANSYKEKKT
     VVLSNSMLIN VDPSSKSYKE ELCTVHFDRV HNPEHCFHIR LEWLTTTPKL IDNMLGNWAR
     ICEKYGLKLI EIPWNELCTI PSVDPFHTFV QLHLVINPWE DPEFNDPELF AVSKFYYHIH
     LLKMSGFLLD NRASRFFQRD DADFEIMYSW GKPQFKYAQY IHTTGAYIAE MRENGNIFLA
     PNNVYMSRVN RANVISKTRS SPTFTVDSRK VVIEFSRTCY SYAKLRAVFL DAKEKWLSNK
     TVED
//

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