(data stored in ACNUC8465 zone)


ID   TIM8_CANGA              Reviewed;          87 AA.
AC   Q6FK81;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 87.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit TIM8;
GN   Name=TIM8; OrderedLocusNames=CAGL0M00418g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mitochondrial intermembrane chaperone that participates
CC       in the import and insertion of some multi-pass transmembrane
CC       proteins into the mitochondrial inner membrane. Also required for
CC       the transfer of beta-barrel precursors from the TOM complex to the
CC       sorting and assembly machinery (SAM complex) of the outer
CC       membrane. Acts as a chaperone-like protein that protects the
CC       hydrophobic precursors from aggregation and guide them through the
CC       mitochondrial intermembrane space. The TIM8-TIM13 complex is non
CC       essential and only mediates the import of few proteins, while the
CC       predominant TIM9-TIM10 70 kDa complex is crucial and mediates the
CC       import of much more proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer; composed of 3 copies of TIM8 and 3 copies
CC       of TIM13, named soluble 70 kDa complex. Associates with the TIM22
CC       complex, whose core is composed of TIM22 and TIM54. Interacts with
CC       the transmembrane regions of multi-pass transmembrane proteins in
CC       transit (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Intermembrane side
CC       {ECO:0000250}.
CC   -!- DOMAIN: The twin CX3C motif contains 4 conserved Cys residues that
CC       form 2 disulfide bonds in the mitochondrial intermembrane space.
CC       However, during the transit of TIM8 from cytoplasm into
CC       mitochondrion, the Cys residues probably coordinate zinc, thereby
CC       preventing folding and allowing its transfer across mitochondrial
CC       outer membrane (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small Tim family. {ECO:0000305}.
DR   EMBL; CR380959; CAG62339.1; -; Genomic_DNA.
DR   RefSeq; XP_449363.1; XM_449363.1.
DR   ProteinModelPortal; Q6FK81; -.
DR   SMR; Q6FK81; -.
DR   STRING; 284593.XP_449363.1; -.
DR   EnsemblFungi; CAG62339; CAG62339; CAGL0M00418g.
DR   KEGG; cgr:CAGL0M00418g; -.
DR   CGD; CAL0136851; CAGL0M00418g.
DR   EuPathDB; FungiDB:CAGL0M00418g; -.
DR   eggNOG; KOG3489; Eukaryota.
DR   eggNOG; ENOG41126D5; LUCA.
DR   HOGENOM; HOG000115758; -.
DR   InParanoid; Q6FK81; -.
DR   KO; K17780; -.
DR   OrthoDB; EOG092C5RBL; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042719; C:mitochondrial intermembrane space protein transporter complex; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008565; F:protein transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0045039; P:protein import into mitochondrial inner membrane; IEA:EnsemblFungi.
DR   Gene3D;; -; 1.
DR   InterPro; IPR004217; Tim10-like.
DR   InterPro; IPR035427; Tim10/FAM136A-like_domain.
DR   Pfam; PF02953; zf-Tim10_DDP; 1.
DR   SUPFAM; SSF144122; SSF144122; 1.
PE   3: Inferred from homology;
KW   Chaperone; Complete proteome; Disulfide bond; Membrane; Metal-binding;
KW   Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW   Reference proteome; Translocation; Transport; Zinc.
FT   CHAIN         1     87       Mitochondrial import inner membrane
FT                                translocase subunit TIM8.
FT                                /FTId=PRO_0000228030.
FT   MOTIF        44     68       Twin CX3C motif.
FT   DISULFID     44     68       {ECO:0000250}.
FT   DISULFID     48     64       {ECO:0000250}.
SQ   SEQUENCE   87 AA;  9685 MW;  FBAF84E5E7BB35AC CRC64;

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