(data stored in ACNUC8465 zone)

SWISSPROT: Q6FK76_CANGA

ID   Q6FK76_CANGA            Unreviewed;       547 AA.
AC   Q6FK76;
DT   19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2004, sequence version 1.
DT   08-MAY-2019, entry version 88.
DE   RecName: Full=alpha-1,2-Mannosidase {ECO:0000256|RuleBase:RU361193};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361193};
GN   OrderedLocusNames=CAGL0M00528g {ECO:0000313|CGD:CAL0137443,
GN   ECO:0000313|EMBL:CAG62344.1};
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593 {ECO:0000313|Proteomes:UP000002428};
RN   [1] {ECO:0000313|EMBL:CAG62344.1, ECO:0000313|Proteomes:UP000002428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC   {ECO:0000313|Proteomes:UP000002428};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.F., Straub M.L., Suleau A.,
RA   Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 47 family.
CC       {ECO:0000256|RuleBase:RU361193}.
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DR   EMBL; CR380959; CAG62344.1; -; Genomic_DNA.
DR   RefSeq; XP_449368.1; XM_449368.1.
DR   STRING; 5478.XP_449368.1; -.
DR   EnsemblFungi; CAG62344; CAG62344; CAGL0M00528g.
DR   GeneID; 2891591; -.
DR   KEGG; cgr:CAGL0M00528g; -.
DR   CGD; CAL0137443; CAGL0M00528g.
DR   EuPathDB; FungiDB:CAGL0M00528g; -.
DR   eggNOG; KOG2431; Eukaryota.
DR   eggNOG; ENOG410XP04; LUCA.
DR   HOGENOM; HOG000181987; -.
DR   InParanoid; Q6FK76; -.
DR   KO; K01230; -.
DR   OMA; DHLTCYL; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblFungi.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IEA:EnsemblFungi.
DR   GO; GO:0035977; P:protein deglycosylation involved in glycoprotein catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0097466; P:ubiquitin-dependent glycoprotein ERAD pathway; IEA:EnsemblFungi.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR001382; Glyco_hydro_47.
DR   InterPro; IPR036026; Seven-hairpin_glycosidases.
DR   Pfam; PF01532; Glyco_hydro_47; 1.
DR   PRINTS; PR00747; GLYHDRLASE47.
DR   SUPFAM; SSF48225; SSF48225; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FK76.
DR   SWISS-2DPAGE; Q6FK76.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002428};
KW   Glycosidase {ECO:0000256|RuleBase:RU361193};
KW   Hydrolase {ECO:0000256|RuleBase:RU361193};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002428};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    547       alpha-1,2-Mannosidase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5004273306.
SQ   SEQUENCE   547 AA;  62921 MW;  4F8CE004720DF2CD CRC64;
     MAYILSAVVL CVSLALWFYN LQTSGFDGDA AAMRNKVEEV FLESWRDYSQ YGWGYDVYSP
     TSHHRHNMLG EERPMGWIIV DSLDTLMVMY NSSANYKDEF REHINAATEW IDRELNFDYD
     NSVSLFETTI RLLGGLLSAY HLSTELDLPQ RYSNIYLDKA QDLGRRLAVA LEVNKDGVPF
     QTVNLKHGIT AMDGGGYTTT PTAEFTTLQM EFKYLAYLTD NSTLWQLSEK LYAPLYLNNN
     LMNQFNGLVP ILTNSQNGRF STATIRLGSM GDSFYEYLLK QYQLTGEEIY RQLYLVSLDG
     IAKHLLGRTT PSNLLFIGER EQGLNGPFST KMDHLVCFIG GVLGMGATNG LHLEQARKAS
     FWNSERESEW LLAKELTKTC YEMYHQVPTG LAPEIVVFND GKARPGHDWW KSKKGDFWIK
     PNDAHNRQRP EAVESIMFLY QLSGNEMYRE WGYEIFQNFI QNTCVDCDDP KSRKYVNLGD
     VTKPGSLGDN METFWLSETL KYMYYLFNDN VDLTSMVFTT EAHIFPRLSH ATLLKKGFET
     NWHKSKK
//

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