(data stored in ACNUC8465 zone)

SWISSPROT: EIF3A_CANGA

ID   EIF3A_CANGA             Reviewed;         951 AA.
AC   Q6FK21;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 70.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE            Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE   AltName: Full=Eukaryotic translation initiation factor 3 110 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
DE            Short=eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03000};
DE   AltName: Full=Translation initiation factor eIF3, p110 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
GN   Name=TIF32 {ECO:0000255|HAMAP-Rule:MF_03000};
GN   OrderedLocusNames=CAGL0M01804g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with
CC       other initiation factors, stimulates binding of mRNA and
CC       methionyl-tRNAi to the 40S ribosome. The eIF-3 complex
CC       specifically targets and initiates translation of a subset of
CC       mRNAs involved in cell proliferation. {ECO:0000255|HAMAP-
CC       Rule:MF_03000}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor
CC       3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit A family.
CC       {ECO:0000255|HAMAP-Rule:MF_03000}.
DR   EMBL; CR380959; CAG62399.1; -; Genomic_DNA.
DR   RefSeq; XP_449423.1; XM_449423.1.
DR   ProteinModelPortal; Q6FK21; -.
DR   SMR; Q6FK21; -.
DR   STRING; 284593.XP_449423.1; -.
DR   PRIDE; Q6FK21; -.
DR   EnsemblFungi; CAG62399; CAG62399; CAGL0M01804g.
DR   KEGG; cgr:CAGL0M01804g; -.
DR   CGD; CAL0136403; CAGL0M01804g.
DR   EuPathDB; FungiDB:CAGL0M01804g; -.
DR   eggNOG; KOG2072; Eukaryota.
DR   eggNOG; ENOG410XQ37; LUCA.
DR   HOGENOM; HOG000246822; -.
DR   InParanoid; Q6FK21; -.
DR   KO; K03254; -.
DR   OMA; QDRDEND; -.
DR   OrthoDB; EOG092C11NJ; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:EnsemblFungi.
DR   GO; GO:0000131; C:incipient cellular bud site; IEA:EnsemblFungi.
DR   GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0002188; P:translation reinitiation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_03000; eIF3a; 1.
DR   InterPro; IPR027512; EIF3A.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   SMART; SM00088; PINT; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FK21.
DR   SWISS-2DPAGE; Q6FK21.
KW   Coiled coil; Complete proteome; Cytoplasm; Initiation factor;
KW   Protein biosynthesis; Reference proteome; RNA-binding.
FT   CHAIN         1    951       Eukaryotic translation initiation factor
FT                                3 subunit A.
FT                                /FTId=PRO_0000366357.
FT   DOMAIN      382    493       PCI. {ECO:0000255|HAMAP-Rule:MF_03000}.
FT   COILED       97    125       {ECO:0000255|HAMAP-Rule:MF_03000}.
FT   COILED      496    532       {ECO:0000255|HAMAP-Rule:MF_03000}.
FT   COILED      592    676       {ECO:0000255|HAMAP-Rule:MF_03000}.
FT   COILED      704    779       {ECO:0000255|HAMAP-Rule:MF_03000}.
FT   COILED      808    909       {ECO:0000255|HAMAP-Rule:MF_03000}.
SQ   SEQUENCE   951 AA;  110157 MW;  DC6B47AEBB351A5A CRC64;
     MAPPPLRPEN ALKRADELIS VNEKPAALQS LYEFITARRI RYATPSQVEP IVFKFLELGV
     ELKKGKLIKD ALYQYKKLVH GSAEGLVSVG AVLRKFIDYV ETKLASEQAK AEEKQKEEVS
     DDLEGGVTPE NLLSSVYEAD HSVAGFNDEA LNSWMRFSWE SYRTALDLLR NNSQLEITYS
     GVVSRTMQFC LKHQRKNEFK RLAEMLRQHL DTANYHQSKF GSNQVDLSDA DTLQRYLDQR
     FQLVDASVKL GLWHEAYKAA EDVYHLMKMT TRKPKSSTLA NYFENLVQIF LVSGDQILHT
     LAWKKYFELY STNPNATEEE FKKIASTIFL SALSIQLDDL PNVRYNYQSR SYRLLDVETK
     PTRKEVIQSI VEDDTIFSRV DAETKTLYEI MEVEFDGESF KGKFEAILPK LEGESYFANY
     SVSLRDVIIR RMFVFASQKY EDISLNDLYS SVTFSSSFKL SEWDIEKQLL QAAVDDYVSF
     QLDHEQNKVT FVKDPLVNFA AIKEEEVEEE EEEEEEEEEE EKEAEGAEGA EGDTEEGQEA
     VAEPEPVIKR NYYIRKRLSE LYEKLLEDTD YNTVSYLDKV RIAREALIKH TKDTIEDMKK
     NSEERAKMHQ ERRRQHMESA AMNAEKDAEQ RQKRIMEERA SIEAKLEEEA HRRLIEKKKR
     EFEEVKQREI RKLVDELNAK GNGTKVEYDE VKDMDIPDIT KYFVNRLSKN KDELEERMNF
     AVKRMDHLER AYRKVELPLL KKQADELRAT DEVNFGNMKK KIVDAAKAEY EAKMEDYNRV
     SSVFDDYKTL RDRMLAAHNE KFAAIRAENA AKLEAAKKAR IEEVRKQRYE ELLARSEAEK
     KAAEEAERRA KLDEIARKQR EMEEALERKS AARTFTQPRA PVVPNANLDE IARKQREMEE
     AIERKLAGKS AAPAPAPAPA ASTPAASTPA APGKMSFAER MRLKRQQQQQ K
//

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