(data stored in ACNUC8465 zone)

SWISSPROT: PRP46_CANGA

ID   PRP46_CANGA             Reviewed;         427 AA.
AC   Q6FJZ9;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 92.
DE   RecName: Full=Pre-mRNA-splicing factor PRP46;
DE   AltName: Full=Pre-mRNA-processing protein 46;
GN   Name=PRP46; OrderedLocusNames=CAGL0M02277g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and required for cell
CC       cycle progression at G2/M. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family.
CC       {ECO:0000305}.
DR   EMBL; CR380959; CAG62421.1; -; Genomic_DNA.
DR   RefSeq; XP_449445.1; XM_449445.1.
DR   ProteinModelPortal; Q6FJZ9; -.
DR   SMR; Q6FJZ9; -.
DR   STRING; 284593.XP_449445.1; -.
DR   EnsemblFungi; CAG62421; CAG62421; CAGL0M02277g.
DR   KEGG; cgr:CAGL0M02277g; -.
DR   CGD; CAL0136351; CAGL0M02277g.
DR   EuPathDB; FungiDB:CAGL0M02277g; -.
DR   eggNOG; KOG0285; Eukaryota.
DR   eggNOG; ENOG410XQV9; LUCA.
DR   HOGENOM; HOG000207595; -.
DR   InParanoid; Q6FJZ9; -.
DR   KO; K12862; -.
DR   OMA; FAMCFDQ; -.
DR   OrthoDB; EOG092C2MHF; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJZ9.
DR   SWISS-2DPAGE; Q6FJZ9.
KW   Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; Spliceosome; WD repeat.
FT   CHAIN         1    427       Pre-mRNA-splicing factor PRP46.
FT                                /FTId=PRO_0000051162.
FT   REPEAT      113    153       WD 1.
FT   REPEAT      156    195       WD 2.
FT   REPEAT      198    237       WD 3.
FT   REPEAT      240    281       WD 4.
FT   REPEAT      283    322       WD 5.
FT   REPEAT      324    362       WD 6.
FT   REPEAT      373    412       WD 7.
SQ   SEQUENCE   427 AA;  48069 MW;  0662CE734354AEEC CRC64;
     MSIGDELVDA DEVYRQARWK NQFEVLSKLP RVLQERVDAQ KPVIEASGNS ATPSNASRAL
     VRHQQNPGDV GLVLNKKFAD EQGHESVIER HDKLLNQTPR WHAPWHLTRV IHGHHGWVRC
     IAMDKVDNEW FATGSNDKTI KIWNLASGKL KVTLKAHDMT VRDLAISNRH PYMFSVSEDK
     TVKCWDLEKN TAIRNYHGHL SGVHTVDIHP TVDVVVTAGR DSVVKVWDIR TRLPVMTLPG
     HKGPITKVRC LPVDPQVISS SVDASIRLWD LVAGKSMKVL THHQRTVRDI SVHPSEFSFA
     SACTNDIRSW LLPKGELLTN FVSQDLDVIN TVSINQDDVL FAGSDNGSLT FFDYKSGHKY
     QTFKTKEAPG SPESERGILS STFDGTGLRL LTGETDRTIK IWKQDETASQ DTHPNLPWNP
     KLDSQRL
//

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