(data stored in ACNUC8465 zone)

SWISSPROT: IRS4_CANGA

ID   IRS4_CANGA              Reviewed;         870 AA.
AC   Q6FJW0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 70.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=IRS4; OrderedLocusNames=CAGL0M03157g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-
CC       bisphosphate turnover and negatively regulates signaling through
CC       the cell integrity pathway. Involved in rDNA silencing (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
DR   EMBL; CR380959; CAG62460.1; -; Genomic_DNA.
DR   RefSeq; XP_449484.1; XM_449484.1.
DR   ProteinModelPortal; Q6FJW0; -.
DR   SMR; Q6FJW0; -.
DR   STRING; 284593.XP_449484.1; -.
DR   EnsemblFungi; CAG62460; CAG62460; CAGL0M03157g.
DR   KEGG; cgr:CAGL0M03157g; -.
DR   CGD; CAL0136569; CAGL0M03157g.
DR   EuPathDB; FungiDB:CAGL0M03157g; -.
DR   eggNOG; ENOG410IRAZ; Eukaryota.
DR   eggNOG; ENOG41124VP; LUCA.
DR   InParanoid; Q6FJW0; -.
DR   OrthoDB; EOG092C2VMY; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000261; EH_dom.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50031; EH; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJW0.
DR   SWISS-2DPAGE; Q6FJW0.
KW   Complete proteome; Lipid metabolism; Reference proteome.
FT   CHAIN         1    870       Increased rDNA silencing protein 4.
FT                                /FTId=PRO_0000308753.
FT   DOMAIN      739    828       EH. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00077}.
FT   COMPBIAS    520    554       Asp-rich.
SQ   SEQUENCE   870 AA;  96331 MW;  AD0EB2060286ED33 CRC64;
     MHMRLNKRRR NHVQEQMSEL PQDAKNDSLA AAQVIFKRHA DNANSTPPSP VGLDSAGHLD
     KQADTAQRVH KVGTPSGTSS SHNSGNEGMH KVTKPLGENT ATTAPIAIKQ PVRVVRASPT
     AIVSPTSHTP LDAATAAANV VAEKSKIRTT QQQLQDKKRR DIENAHHAAS AAAVTSSNLA
     VGSPPSQYIP SVPTLNVTSP QMRNSSQNID RRSKSNEEAH NGHEKMMNSR SNSINSSTIK
     GSVSEPNTVT PLRQNSPSNM DDIIQKMEAV DIDEGRKNSF VMNGSGDSVD SLKPNVVRRP
     MRTPSGRRVR PPSPIDKIGS IQEPHLESTG FNDQNDFSEM SSLIDGSSSE DITKIRGSGI
     RERSPVDGVE HGGMSVNIPM QRSLSSDVLS PSQQAAMVAA TKLSPSTQTL PVEELEYLAS
     TGDVSAYKAL NKINGTNMAY KGTIPDLIPS RARAQKTSKL KFKIFGGGKN SDRRNNATPI
     GYDPVMNIST DFGGKKVVES NQNNVKFKTT MRSQKYLGND NLDDNDLRTQ YIDDDDDDDD
     YDSAYEDLDY SRDDSEAMYK GDRESSNPRS NSLLQSSSYS GKVGFNSNAN SGTSINNSGN
     VSNLDYSLRD GVAEKKKSRR DKIKKKLKST ASVVPYYPHY ALTHLASGVS TVNSNLNNSN
     KNTKWFNEDK PWKSHKDVGF VTSQERKRYE AMWVTNRYLY LNLLPWWPKE EVEKDEDDSA
     SNLNSNASTN VGGVLSDGDN EEDDVTRFLL SLPADGLMLN LVAKDIWERS NLPNDLLKQI
     YDLVDTRKDG TLNRESFLVG MWLVDQCLYG RKLPQELDPK IWDSVDRWVL NVVNSTMMTA
     LERKQKKKMM KKELKNIKRE QKQAIAEQHN
//

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