(data stored in ACNUC8465 zone)

SWISSPROT: PALH_CANGA

ID   PALH_CANGA              Reviewed;         539 AA.
AC   Q6FJT9;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 68.
DE   RecName: Full=pH-response regulator protein palH/RIM21;
GN   Name=RIM21; OrderedLocusNames=CAGL0M03663g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the
CC       transcription factor RIM101 in response to alkaline ambient pH.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the palH/RIM21 family. {ECO:0000305}.
DR   EMBL; CR380959; CAG62481.1; -; Genomic_DNA.
DR   RefSeq; XP_449505.1; XM_449505.1.
DR   STRING; 284593.XP_449505.1; -.
DR   EnsemblFungi; CAG62481; CAG62481; CAGL0M03663g.
DR   KEGG; cgr:CAGL0M03663g; -.
DR   CGD; CAL0136835; CAGL0M03663g.
DR   EuPathDB; FungiDB:CAGL0M03663g; -.
DR   eggNOG; ENOG410IJHA; Eukaryota.
DR   eggNOG; ENOG410ZR7Q; LUCA.
DR   InParanoid; Q6FJT9; -.
DR   OMA; CVVIPWE; -.
DR   OrthoDB; EOG092C27BG; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR014844; PalH.
DR   Pfam; PF08733; PalH; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJT9.
DR   SWISS-2DPAGE; Q6FJT9.
KW   Cell membrane; Complete proteome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    539       pH-response regulator protein palH/RIM21.
FT                                /FTId=PRO_0000058198.
FT   TOPO_DOM      1    101       Extracellular. {ECO:0000255}.
FT   TRANSMEM    102    122       Helical. {ECO:0000255}.
FT   TOPO_DOM    123    130       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    131    151       Helical. {ECO:0000255}.
FT   TOPO_DOM    152    172       Extracellular. {ECO:0000255}.
FT   TRANSMEM    173    193       Helical. {ECO:0000255}.
FT   TOPO_DOM    194    213       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    214    234       Helical. {ECO:0000255}.
FT   TOPO_DOM    235    248       Extracellular. {ECO:0000255}.
FT   TRANSMEM    249    269       Helical. {ECO:0000255}.
FT   TOPO_DOM    270    284       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    285    305       Helical. {ECO:0000255}.
FT   TOPO_DOM    306    310       Extracellular. {ECO:0000255}.
FT   TRANSMEM    311    331       Helical. {ECO:0000255}.
FT   TOPO_DOM    332    539       Cytoplasmic. {ECO:0000255}.
SQ   SEQUENCE   539 AA;  61219 MW;  AD981622A39541BF CRC64;
     MAVSIYDSLR TPGPKHYKYK ICDGIDLGDG LVIDPLNLDS LVVYAKNVKW SSFCDYGVPL
     YLAADTMDTP YEYPPIIMND WRWFIFNDHY FGKYWGYGLY TILMVYSTIF VITVALTVLS
     FLTVNKGPYK ITSLLLKLSS VLASTSIIYF LTSALSTISR QQEHYGVANG NVFGTLLNSN
     LVIATLNLLS MFFYKLCQVS IVARLFERKL EWRIVVFVGG IMSIVSFIIS AIVSYTDRVG
     IRNDNLVTLS PFGLLFDIAL ETCFAFIIVT NVWGTRKTWV SHLQMWYLAL LTIAIVLLSP
     AMFLADVGTG LLSAYAATVS PLLYTMSTFV AWEWLERIHI LKKAAQVKSL LGQKIYEDEQ
     EGYNFAYYSV NNESNLDTNS DSHISLYNDM FRNSEQFSNV GSNLSSKESS SLPAQMNSTG
     ISFPTAVNQV EFQKRKSFLD HLTNFTYSRP YKIYKKSKSI IQLRKRNSET VKNERSNEEL
     SIEKVRRRLG LTNERREYVY NTKDIVFASD DDTESECESN NILNESIDSH FPENGAGSV
//

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