(data stored in ACNUC8465 zone)

SWISSPROT: PFS2_CANGA

ID   PFS2_CANGA              Reviewed;         455 AA.
AC   Q6FJS0;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   08-MAY-2019, entry version 99.
DE   RecName: Full=Polyadenylation factor subunit 2;
GN   Name=PFS2; OrderedLocusNames=CAGL0M04081g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC       mRNAs. Also involved in chromosome segregation where it has a role
CC       in chromosome attachment to the mitotic spindle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
DR   EMBL; CR380959; CAG62500.1; -; Genomic_DNA.
DR   RefSeq; XP_449524.1; XM_449524.1.
DR   STRING; 5478.XP_449524.1; -.
DR   PRIDE; Q6FJS0; -.
DR   EnsemblFungi; CAG62500; CAG62500; CAGL0M04081g.
DR   GeneID; 2891533; -.
DR   KEGG; cgr:CAGL0M04081g; -.
DR   CGD; CAL0136357; CAGL0M04081g.
DR   EuPathDB; FungiDB:CAGL0M04081g; -.
DR   eggNOG; KOG0284; Eukaryota.
DR   eggNOG; COG2319; LUCA.
DR   HOGENOM; HOG000213918; -.
DR   InParanoid; Q6FJS0; -.
DR   KO; K15542; -.
DR   OMA; GHHWDVK; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:EnsemblFungi.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IEA:EnsemblFungi.
DR   GO; GO:0098789; P:pre-mRNA cleavage required for polyadenylation; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJS0.
DR   SWISS-2DPAGE; Q6FJS0.
KW   Chromosome partition; Complete proteome; mRNA processing; Nucleus;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN         1    455       Polyadenylation factor subunit 2.
FT                                /FTId=PRO_0000238499.
FT   REPEAT       80    119       WD 1.
FT   REPEAT      122    162       WD 2.
FT   REPEAT      164    203       WD 3.
FT   REPEAT      206    245       WD 4.
FT   REPEAT      248    288       WD 5.
FT   REPEAT      291    331       WD 6.
FT   REPEAT      337    376       WD 7.
SQ   SEQUENCE   455 AA;  51570 MW;  58AE916549E3C8E2 CRC64;
     MDQSAAVEGV PQKKYLTLRR SVDVSSSYNR LYYLKKHGLS LPPIEPETSF TANIMPPDAY
     KRNDRIVNLP TKFTHLSSNK VKHVIPAIQW SPEGRRLIVA TFSGEFSLWN GSSFTFETIM
     QAHDTSVTTM KYSHAGDWMI SGDADGTIKI WQPNFNMVKE LDRIHTEGIR DVAFSNNDSK
     FVTCSDDNIL KIWNFSNGQQ ERVLSGHHWD VRSCDWHPEL GLIVSGSKDN LVKLWDPRSG
     QCVSTLLKFK HTVLKTRFQP TKGNLLAAIS KDKSCRVFDL RASMNELMCV RDEVDFMELE
     WSTINESMFT VGCYDGSLKH FDLGQDTEKP IHIIPFAHEK CISAIAYNPV GHILATAAKD
     RTIRFWTRAR PVDPNAFDDP TYNNKKMTGW FFGINNDINA VREKSEYGAA PPPASTAFPQ
     QTQYNNNISR VPEIKEPTPT TDKEQRTSIL PGLSI
//

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