(data stored in ACNUC8465 zone)

SWISSPROT: DCN1_CANGA

ID   DCN1_CANGA              Reviewed;         273 AA.
AC   Q6FJR2;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 76.
DE   RecName: Full=Defective in cullin neddylation protein 1;
GN   Name=DCN1; OrderedLocusNames=CAGL0M04257g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May contribute to neddylation of cullin components of
CC       SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins
CC       play an essential role in the regulation of SCF-type complexes
CC       activity (By similarity). {ECO:0000250}.
DR   EMBL; CR380959; CAG62508.1; -; Genomic_DNA.
DR   RefSeq; XP_449532.1; XM_449532.1.
DR   ProteinModelPortal; Q6FJR2; -.
DR   SMR; Q6FJR2; -.
DR   STRING; 284593.XP_449532.1; -.
DR   EnsemblFungi; CAG62508; CAG62508; CAGL0M04257g.
DR   KEGG; cgr:CAGL0M04257g; -.
DR   CGD; CAL0137307; CAGL0M04257g.
DR   EuPathDB; FungiDB:CAGL0M04257g; -.
DR   eggNOG; KOG3077; Eukaryota.
DR   eggNOG; ENOG410XTIJ; LUCA.
DR   HOGENOM; HOG000112177; -.
DR   InParanoid; Q6FJR2; -.
DR   KO; K17822; -.
DR   OMA; MITDDMS; -.
DR   OrthoDB; EOG092C3OM7; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0097602; F:cullin family protein binding; IEA:EnsemblFungi.
DR   GO; GO:0030674; F:protein binding, bridging; IEA:EnsemblFungi.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:EnsemblFungi.
DR   GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IEA:EnsemblFungi.
DR   GO; GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IEA:EnsemblFungi.
DR   GO; GO:0045116; P:protein neddylation; IEA:EnsemblFungi.
DR   InterPro; IPR014764; DCN-prot.
DR   InterPro; IPR005176; PONY_dom.
DR   InterPro; IPR009060; UBA-like.
DR   PANTHER; PTHR12281; PTHR12281; 1.
DR   Pfam; PF03556; Cullin_binding; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   PROSITE; PS51229; DCUN1; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJR2.
DR   SWISS-2DPAGE; Q6FJR2.
KW   Complete proteome; Reference proteome; Ubl conjugation pathway.
FT   CHAIN         1    273       Defective in cullin neddylation protein
FT                                1.
FT                                /FTId=PRO_0000129511.
FT   DOMAIN        6     44       UBA-like.
FT   DOMAIN       62    268       DCUN1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00574}.
SQ   SEQUENCE   273 AA;  32739 MW;  778CD4D838998EC7 CRC64;
     MVSRHEKELM KTFQSLTSCT DEGKAKRYLS ANNWNINYAL NEYYDKEVGG FTEDHMIRHQ
     FKYPDELVSL FGHYAALIEE DGTQSITPDG LIDYIQDLGY NLEDLVTISL AHFLQCKNLE
     NPITEKQFLY FWYNEGCYTL EQMRHYLEDC ERKLCNDWKY FTTIYNYSFD LNASKQGVVE
     TDIAIEYWKL FFEENRTKLS GIIKVDQAHL DLWCKFLQDE HKKLIHKDTW QMLLLFFKKF
     PSLDAIKTEY NEADAWPYTI DEFYEYLEER NVL
//

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